Overview By Mayo Clinic Staff Print Epithelioid sarcoma is a rare type of cancer that starts as a growth of cells in the soft tissue. It can happen anywhere on the body. It often starts under the skin on the finger, hand, forearm, knee or lower leg. Epithelioid sarcoma can happen at any age. It most often affects teenagers and young to middle-aged adults. Epithelioid sarcoma tends to grow slowly. It can come back after treatment. Epithelioid sarcoma is a type of cancer called a soft tissue sarcoma. These cancers happen in the body's connective tissues. There are many types of soft tissue sarcoma. Soft tissue sarcomas, including epithelioid sarcoma, are not common. It is best to seek care at a cancer center that has experience treating people with sarcoma. Request an appointment Diagnosis & treatment March 24, 2026 Print Share on: FacebookTwitter Living with epithelioid sarcoma? Connect with others like you for support and answers to your questions in the Sarcoma support group on Mayo Clinic Connect, a patient community. Sarcoma Discussions Anyone have experience with gastrointestinal stromal tumor (GIST)? 106 Replies Thu, Jul 02, 2026 chevron-right Diagnosed with sarcoma? Let's share 1070 Replies Thu, Jun 25, 2026 chevron-right Undifferentiated Pleomorphic Sarcoma: Anyone else want to share? 136 Replies Wed, Jun 24, 2026 chevron-right See more discussions Show references Goldblum JR, et al. Other malignant soft tissue tumors, including those of uncertain type. In: Enzinger and Weiss's Soft Tissue Tumors. 7th ed. Elsevier; 2020. https://www.clinicalkey.com. Accessed Jan. 5, 2023. Schuetze SM, et al. Uncommon sarcoma subtypes. https://www.uptodate.com/contents/search. Accessed Jan. 5, 2023. Sarcomas, soft tissue — Introduction. Cancer.Net. https://www.cancer.net/cancer-types/sarcoma/view-all. Accessed Jan. 5, 2023. Soft tissue sarcoma. National Comprehensive Cancer Network. https://www.nccn.org/guidelines/guidelines-detail?category=1&id=1464. Accessed Dec. 20, 2024. Meissner M, et al. Pharmacotherapeutic strategies for epithelioid sarcoma: Are we any closer to a non-surgical cure? Expert Opinion on Pharmacotherapy. 2023; doi:10.1080/14656566.2023.2224500. Related Products & Services A Book: Mayo Clinic Family Health Book Newsletter: Mayo Clinic Health Letter — Digital Edition Show more products and services from Mayo Clinic Epithelioid sarcomaSymptoms&causesDiagnosis&treatmentDoctors&departments Advertisement Mayo Clinic does not endorse companies or products. Advertising revenue supports our not-for-profit mission. Advertising & Sponsorship Policy Opportunities Ad Choices Mayo Clinic Press Check out these best-sellers and special offers on books and newsletters from Mayo Clinic Press. NEW: Mayo Clinic Guide to Better Sleep Listen to Health Matters Podcast Mayo Clinic on Incontinence The Essential Diabetes Book FREE Mayo Clinic Diet Assessment Mayo Clinic Health Letter - FREE book CON-20380728 Diseases & Conditions Epithelioid sarcoma