Overview

Dressler syndrome is swelling and irritation of the sac around the heart that happens after damage to the heart muscle. The damage may trigger an immune system response that causes the condition. The damage can result from a heart attack, heart surgery or a serious injury.

Symptoms of Dressler syndrome include chest pain that can feel like chest pain from a heart attack.

Swelling and irritation of the sac around the heart is called pericarditis. Dressler syndrome is a type of pericarditis that can start after the heart muscle is damaged. So you may hear Dressler syndrome called post-traumatic pericarditis.

Some other names for the condition are:

  • Post-myocardial infarction syndrome.
  • Post-cardiac injury syndrome.
  • Post-pericardiotomy syndrome.

Symptoms

Symptoms of Dressler syndrome are likely to start weeks to a few months after a heart attack, surgery or injury to the chest. Symptoms can include:

  • Chest pain, which may get worse with deep breaths.
  • Fever.
  • Shortness of breath.

When to see a doctor

Get emergency care for sudden or ongoing chest pain. This can be a symptom of a heart attack or another serious condition.

Causes

Experts think Dressler syndrome is caused by the immune system's response to heart damage. The body reacts to the injured tissue by sending immune cells and proteins called antibodies to clean up and repair the affected area. Sometimes this response causes swelling due to the inflammation in the sac around the heart that's known as the pericardium.

Dressler syndrome can happen after a heart attack or some heart surgeries or procedures. It also can happen after a serious injury to the chest, such as trauma from a car accident.

Risk factors

Damage to the heart muscle increases the risk of Dressler syndrome. Some things that cause heart muscle are:

  • Chest injury.
  • Some types of heart surgery.
  • Heart attack.

Complications

A complication of Dressler syndrome is fluid buildup in the tissues surrounding the lungs called pleural effusion.

Rarely, Dressler syndrome can cause more-serious complications, including:

  • Cardiac tamponade. Swelling of the pericardium can cause fluid to build up in the sac. The fluid can put pressure on the heart. The pressure forces the heart to work harder, and the heart doesn't pump blood as well as it should.
  • Constrictive pericarditis. Swelling that's ongoing or that keeps coming back can cause the pericardium to become thick or scarred. The scarring can reduce the heart's ability to pump blood.

Prevention

Some studies suggest that taking the anti-inflammatory medicine colchicine (Colcrys, Gloperba, others) soon after heart surgery may help prevent Dressler syndrome.

Aug. 31, 2024
  1. LeWinter MM. Pericardial complications of myocardial infarction. https://www.uptodate.com/contents/search. Accessed April 17, 2024.
  2. Hoit BD. Post-cardiac injury syndromes. https://www.uptodate.com/contents/search. Accessed April 17, 2024.
  3. Hoit BD. Etiology of pericardial disease. https://www.uptodate.com/contents/search. Accessed April 17, 2024.
  4. Libby P, et al., eds. Pericardial diseases. In: Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine. 12th ed. Elsevier; 2022. https://www.clinicalkey.com. Accessed April 17, 2024.
  5. Walls RM, et al., eds. Pericardial and myocardial disease. In: Rosen's Emergency Medicine: Concepts and Clinical Practice. 10th ed. Elsevier; 2023. https://www.clinicalkey.com. Accessed April 17, 2024.
  6. Mankad R (expert opinion). Mayo Clinic. April 29, 2024.
  7. Health Education & Content Services. Pericarditis: Symptoms, diagnosis and treatment. Mayo Clinic; 2023.