Acanthosis nigricans is a skin condition characterized by areas of dark, velvety discoloration in body folds and creases. The affected skin can become thickened. Most often, acanthosis nigricans affects your armpits, groin and neck.
The skin changes of acanthosis nigricans (ak-an-THOE-sis NIE-grih-kuns) typically occur in people who are obese or have diabetes. Children who develop the condition are at higher risk of developing type 2 diabetes. Rarely, acanthosis nigricans can be a warning sign of a cancerous tumor in an internal organ, such as the stomach or liver.
No specific treatment is available for acanthosis nigricans. Treatment of underlying conditions may restore some of the normal color and texture to affected areas of skin.
Skin changes are the only signs of acanthosis nigricans. You'll notice dark, thickened, velvety skin in body folds and creases — typically in your armpits, groin and back of the neck. The skin changes usually appear slowly. The affected skin may also have an odor or itch.
When to see a doctor
Consult your doctor if you notice changes in your skin — especially if the changes appear suddenly. You may have an underlying condition that needs treatment.
Acanthosis nigricans has been associated with:
- Insulin resistance. Most people who have acanthosis nigricans have also become resistant to insulin. Insulin is a hormone secreted by the pancreas that allows your body to process sugar. Insulin resistance is what eventually causes type 2 diabetes.
- Hormonal disorders. Acanthosis nigricans often occurs in people who have disorders such as ovarian cysts, underactive thyroids or problems with the adrenal glands.
- Certain drugs and supplements. High-dose niacin, birth control pills, prednisone and other corticosteroids may cause acanthosis nigricans.
- Cancer. Acanthosis nigricans also sometimes occurs with lymphoma or when a cancerous tumor begins growing in an internal organ, such as the stomach, colon or liver.
Acanthosis nigricans risk factors include:
- Obesity. The heavier you are, the higher your risk of acanthosis nigricans.
- Race. Studies show that in the United States, acanthosis nigricans is more common among Native Americans.
- Family history. Some types of acanthosis nigricans appear to be hereditary.
People who have acanthosis nigricans are much more likely to develop type 2 diabetes.
April 24, 2018
- AskMayoExpert. Polycystic ovary syndrome. Rochester, Minn.: Mayo Foundation for Medical Education and Research; 2014.
- Habif TP. Cutaneous manifestations of internal disease. In: Clinical Dermatology: A Color Guide to Diagnosis and Therapy. 5th ed. Edinburgh, U.K.; New York, N.Y.: Mosby Elsevier; 2010. http://www.clinicalkey.com. Accessed March 25, 2015.
- Niacin and niacinamide (vitamin B3). Natural Medicines Comprehensive Database. http://naturaldatabase.therapeuticresearch.com. Accessed March 27, 2015.
- Gibson LE. Acanthosis nigricans. Mayo Clinic Proceedings. 2004;79:1571.
- Goldsmith LA, et al., eds. Diabetes Mellitus and other endocrine diseases. In: Fitzpatrick's Dermatology in General Medicine. 8th ed. New York, N.Y.: The McGraw-Hill Companies; 2012. http://www.accessmedicine.com. Accessed March 25, 2015.
- Goldsmith LA, et al., eds. Cutaneous manifestations of internal malignant disease. In: Fitzpatrick's Dermatology in General Medicine. 8th ed. New York, N.Y.: The McGraw-Hill Companies; 2012. http://www.accessmedicine.com. Accessed March 25, 2015.
- Braunstein I. Acanthosis nigricans. http://www.uptodate.com/home. Accessed March 25, 2015.
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