Clinical trials Below are current clinical trials.4 studies in Addiction Services (open studies only). Filter this list of studies by location, status and more. A Study to Evaluate AAV8-human Cocaine Hydrolase to Treat Cocaine Use Disorder Rochester, Minn. The purpose of this study is to see if an experimental agent, when given to subjects who wish to abstain from cocaine, will decrease their craving for cocaine and prevent them from relapsing and returning to cocaine use. This experimental agent is called AAV8-hCocH; and it is a gene modified viral vector. We want to determine the safety of its use in adults who have a cocaine use disorder in sustained remission. Attitudes and Beliefs About Gene Transfer Therapy in Adults with Cocaine Use Disorder Rochester, Minn. The purpose of this study is to investigate the facilitators and barriers of adults with a history of cocaine use disorder (CocUD) in sustained remission to participating in a Phase I gene transfer study aimed at reducing the rate of cocaine relapse. A Study to Evaluate the Safety, Tolerability and Effectiveness of V117957 in Subjects with Insomnia Associated with Alcohol Cessation Rochester, Minn. The purpose of this study is to evaluate the safety, tolerability and effectiveness of V117957, compared to placebo, in subjects with alcohol use disorder (AUD) who experience insomnia associated with alcohol cessation. A Study to Analyse the Genetic Makeup of Those with Opioid and Substance Use Disorders Rochester, Minn., Albert Lea, Minn. The purpose of this study is to establish an opioid and multiple addiction (OMA) biobank that creates a comprehensive standard patient phenotype using standardized subjective assessments and objective behavioral measurements for future research. Request an appointment ResearchReferrals July 15, 2025 Share on: FacebookTwitter Addiction ServicesSectionsOverviewSpecialty groupsDoctorsResearchClinical trialsReferralsRequest an appointment Research: It's all about patients Show transcript for video Research: It's all about patients [MUSIC PLAYING] Joseph Sirven, M.D., Professor of Neurology, Mayo Clinic: Mayo's mission is about the patient. The patient comes first. So the mission and research here is to advance how we can best help the patient, how to make sure the patient comes first in care. So in many ways, it's a cycle. It can start with as simple as an idea worked on in a laboratory, brought to the patient bedside, and if everything goes right — and let's say it's helpful or beneficial — then brought on as a standard approach. And I think that is one of the unique characteristics of Mayo's approach to research — that patient-centeredness — that really helps to put it in its own spotlight. SectionsRequest an AppointmentOverviewSpecialty groupsDoctorsResearchClinical trialsReferrals ORG-20560246 Medical Departments & Centers Addiction Services