Erik J. Tryggestad, Ph.D.

  1. Radiation Oncology Medical Physicist

Publications

  1. Smith EJ, Tryggestad EJ, Carlson BL, Walb MC, Sarkaria JN. Imaging and Dosimetry Study of Inter-fraction Setup Error in a Murine Xenograft Flank Tumor Radiation Model. Radiat Res. 2020 Feb; 193 (2):161-170 Epub 2019 Dec 26
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  2. Jethwa KR, Haddock MG, Tryggestad EJ, Hallemeier CL. The emerging role of proton therapy for esophagus cancer. J Gastrointest Oncol. 2020 Feb; 11 (1):144-156
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  3. Tryggestad EJ, Liu W, Pepin MD, Hallemeier CL, Sio TT. Managing treatment-related uncertainties in proton beam radiotherapy for gastrointestinal cancers. J Gastrointest Oncol. 2020 Feb; 11 (1):212-224
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  4. Alcorn SR, Zhou XC, Bojechko C, Rubo RA, Chen MJ, Dieckmann K, Ermoian RP, Ford EC, Kobyzeva D, MacDonald SM, McNutt TR, Nechesnyuk A, Nilsson K, Sjostrand H, Smith KS, Stock M, Tryggestad EJ, Villar RC, Winey BA, Terezakis SA. Low-Dose Image-Guided Pediatric CNS Radiation Therapy: Final Analysis From a Prospective Low-Dose Cone-Beam CT Protocol From a Multinational Pediatrics Consortium. Technol Cancer Res Treat. 2020 Jan-Dec; 19:1533033820920650
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  5. Tryggestad Erik, Liu Wei, Hallemeier Christopher, Pepin Mark, Sio Terence. Managing treatment-related uncertainties in proton beam Journal of Gastrointestinal Oncology. 12/21/2019.
  6. Garant A, Whitaker TJ, Spears GM, Routman DM, Harmsen WS, Wilhite TJ, Ashman JB, Sio TT, Rule WG, Neben Wittich MA, Martenson JA, Tryggestad EJ, Yoon HH, Blackmon S, Merrell KW, Haddock MG, Hallemeier CL. A Comparison of Patient-Reported Health-Related Quality of Life During Proton Versus Photon Chemoradiation Therapy for Esophageal Cancer. Pract Radiat Oncol. 2019 Nov; 9 (6):410-417 Epub 2019 July 13
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  7. Kang Y, Shen J, Liu W, Taylor PA, Mehrens HS, Ding X, Hu Y, Tryggestad E, Keole SR, Schild SE, Wong WW, Fatyga M, Bues M. Impact of planned dose reporting methods on Gamma pass rates for IROC lung and liver motion phantoms treated with pencil beam scanning protons. Radiat Oncol. 2019 Jun 17; 14 (1):108 Epub 2019 June 17
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  8. Pepin MD, Tryggestad EJ, Wan H, Ma J, Abdel-Rehim A, Johnson JE, Herman MG, Beltran C. Monte-Carlo-based 4D robust optimization using physical and temporal uncertainties for intensity modulated proton therapy Medical Physics. 2019.
  9. Gelover E, Deisher AJ, Herman MG, Johnson JE, Kruse JJ, Tryggestad EJ. Clinical implementation of respiratory-gated spot-scanning proton therapy: An efficiency analysis of active motion management. J Appl Clin Med Phys. 2019 May; 20 (5):99-108 Epub 2019 Apr 10
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  10. Walb MC, Carlson BL, Sarkaria JN, Tryggestad EJ. Quantifying the setup uncertainty of a stereotactic murine micro-image guided radiation therapy system. Br J Radiol. 2019 Mar; 92 (1095):20180487 Epub 2018 Nov 14
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  11. Pepin MD, Tryggestad E, Wan Chan Tseung HS, Johnson JE, Herman MG, Beltran C. A Monte-Carlo-based and GPU-accelerated 4D-dose calculator for a pencil beam scanning proton therapy system. Med Phys. 2018 Nov; 45 (11):5293-5304 Epub 2018 Oct 31
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  12. Jethwa KR, Tryggestad EJ, Whitaker TJ, Giffey BT, Kazemba BD, Neben-Wittich MA, Merrell KW, Haddock MG, Hallemeier CL. Initial experience with intensity modulated proton therapy for intact, clinically localized pancreas cancer: Clinical implementation, dosimetric analysis, acute treatment-related adverse events, and patient-reported outcomes. Adv Radiat Oncol. 2018 Jul-Sep; 3 (3):314-321 Epub 2018 Apr 13
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  13. Gleeson FC, Tryggestad EJ, Remmes NB, Beltran CJ, Kruse JJ, Haddock MG, Hallemeier CL, Storm AC, Levy MJ. Knowledge of endoscopic ultrasound-delivered fiducial composition and dimension necessary when planning proton beam radiotherapy. Endosc Int Open. 2018 Jun; 6 (6):E766-E768 Epub 2018 June 05
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  14. Cho N, Tsiamas P, Velarde E, Tryggestad E, Jacques R, Berbeco R, McNutt T, Kazanzides P, Wong J. Validation of GPU-accelerated superposition-convolution dose computations for the Small Animal Radiation Research Platform. Med Phys. 2018 Mar 15 [Epub ahead of print]
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  15. Park S, Farah R, Shea SM, Tryggestad E, Hales R, Lee J. Simultaneous tumor and surrogate motion tracking with dynamic MRI for radiation therapy planning. Phys Med Biol. 2018 Jan 11; 63 (2):025015
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  16. Shen J, Tryggestad E, Younkin JE, Keole SR, Furutani KM, Kang Y, Herman MG, Bues M. Technical Note: Using experimentally determined proton spot scanning timing parameters to accurately model beam delivery time. Med Phys. 2017 Oct; 44 (10):5081-5088 Epub 2017 Aug 30
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  17. Weavers PT, Tao S, Trzasko JD, Shu Y, Tryggestad EJ, Gunter JL, McGee KP, Litwiller DV, Hwang KP, Bernstein MA. Image-based gradient non-linearity characterization to determine higher-order spherical harmonic coefficients for improved spatial position accuracy in magnetic resonance imaging. Magn Reson Imaging. 2017 May; 38:54-62 Epub 2016 Dec 27
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  18. Park S, Farah R, Shea SM, Tryggestad E, Hales R, Lee J. Evaluation of lung tumor motion management in radiation therapy with dynamic MRI. Proc SPIE Int Soc Opt Eng. 2017 Feb 11; 10135 Epub 2017 Mar 03
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  19. Sio TT, Merrell KW, Beltran CJ, Ashman JB, Hoeft KA, Miller RC, Whitaker TJ, Wurgler SK, Tryggestad EJ. Spot-scanned pancreatic stereotactic body proton therapy: A dosimetric feasibility and robustness study. Phys Med. 2016 Feb; 32: (2)331-42.
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  20. Zhang Y, Ding K, Cowan G, Tryggestad E, Armour E, Wang KK. Alignment of multiradiation isocenters for megavoltage photon beam. J Appl Clin Med Phys. 2015 Nov 8; 16 (6):314-324 Epub 2015 Nov 08
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  21. Grams MP, Wilson ZC, Sio TT, Beltran CJ, Tryggestad EJ, Gupta SK, Blackwell CR, McCollough KP, Sarkaria JN, Furutani KM. Design and characterization of an economical (192)Ir hemi-brain small animal irradiator. Int J Radiat Biol. 2014 Oct; 90 (10):936-942 Epub 2014 June 25
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  22. Alcorn SR, Chen MJ, Claude L, Dieckmann K, Ermoian RP, Ford EC, Malet C, MacDonald SM, Nechesnyuk AV, Nilsson K, Villar RC, Winey BA, Tryggestad EJ, Terezakis SA. Practice patterns of photon and proton pediatric image guided radiation treatment: results from an International Pediatric Research consortium. Pract Radiat Oncol. 2014 Sep-Oct; 4 (5):336-341 Epub 2014 May 14
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  23. Whitaker TJ, Beltran C, Tryggestad E, Bues M, Kruse JJ, Remmes NB, Tasson A, Herman MG. Comparison of two methods for minimizing the effect of delayed charge on the dose delivered with a synchrotron based discrete spot scanning proton beam. Med Phys. 2014 Aug; 41 (8):081703
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  24. Dholakia AS, Chaudhry M, Leal JP, Chang DT, Raman SP, Hacker-Prietz A, Su Z, Pai J, Oteiza KE, Griffith ME, Wahl RL, Tryggestad E, Pawlik T, Laheru DA, Wolfgang CL, Koong AC, Herman JM. Baseline Metabolic Tumor Volume and Total Lesion Glycolysis Are Associated With Survival Outcomes in Patients With Locally Advanced Pancreatic Cancer Receiving Stereotactic Body Radiation Therapy. Int J Radiat Oncol Biol Phys 1. 2014 Jul 1; 89(3):539-46. Epub 2015 Apr 18
  25. Zellars R, Bravo PE, Tryggestad E, Hopfer K, Myers L, Tahari A, Asrari F, Ziessman H, Garrett-Mayer E. SPECT analysis of cardiac perfusion changes after whole-breast/chest wall radiation therapy with or without active breathing coordinator: results of a randomized phase 3 trial. Int J Radiat Oncol Biol Phys. 2014 Mar 15; 88: (4)778-85.
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  26. Wack L, Ngwa W, Tryggestad E, Tsiamas P, Berbeco R, Ng SK, Hesser J, Zygmanski P. High throughput film dosimetry in homogeneous and heterogeneous media for a small animal irradiator. Phys Med doi 101016. 2014 Feb; 30(1):36-46. Epub 2013 Mar 17
  27. Wada S, Harris TJ, Tryggestad E, Yoshimura K, Zeng J, Yen HR, Getnet D, Grosso JF, Bruno TC, De Marzo AM, Netto GJ, Pardoll DM, DeWeese TL, Wong J, Drake CG. Combined treatment effects of radiation and immunotherapy: studies in an autochthonous prostate cancer model. Int J Radiat Oncol Biol Phys. 2013 Nov 15; 87(4):769-76. Epub 2013 Sep 21.
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  28. Tryggestad E, Flammang A, Hales R, Herman J, Lee J, McNutt T, Roland T, Shea SM, Wong J. 4D tumor centroid tracking using orthogonal 2D dynamic MRI: implications for radiotherapy planning. Med Phys. 2013 Sep; 40(9):091712.
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  29. Marco-Rius I, Wack L, Tsiamas P, Tryggestad E, Berbeco R, Hesser J, Zygmanski P. A fast analytic dose calculation method for arc treatments for kilovoltage small animal irradiators. Phys Med. 2013 Sep; 29(5):426-35. Epub 2013 Mar 13
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  30. Kumar R, Wild AT, Ziegler MA, Hooker TK, Dah SD, Tran PT, Kang J, Smith K, Zeng J, Pawlik TM, Tryggestad E, Ford E, Herman JM. Stereotactic body radiation therapy planning with duodenal sparing using volumetric-modulated arc therapy vs intensity-modulated radiation therapy in locally advanced pancreatic cancer: a dosimetric analysis. Med Dosim. 2013 Autumn; 38(3):243-50. Epub 2013 Mar 27.
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  31. Reaungamornrat S, Liu WP, Wang AS, Otake Y, Nithiananthan S, Uneri A, Schafer S, Tryggestad E, Richmon J, Sorger JM, Siewerdsen JH, Taylor RH. Deformable image registration for cone-beam CT guided transoral robotic base-of-tongue surgery. Phys Med Biol. 2013 Jul 21; 58(14):4951-79. Epub 2013 Jun 27.
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  32. Tryggestad E, Flammang A, Han-Oh S, Hales R, Herman J, McNutt T, Roland T, Shea SM, Wong J. Respiration-based sorting of dynamic MRI to derive representative 4D-MRI for radiotherapy planning. Med Phys. 2013 May; 40(5):051909.
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  33. Khashab MA, Kim KJ, Tryggestad EJ, Wild AT, Roland T, Singh VK, Lennon AM, Shin EJ, Ziegler MA, Sharaiha RZ, Canto MI, Herman JM. Comparative analysis of traditional and coiled fiducials implanted during EUS for pancreatic cancer patients receiving stereotactic body radiation therapy. Gastrointest Endosc. 2012 Nov; 76(5):962-71.
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  34. Roland T, Tryggestad E, Mavroidis P, Hales R, Papanikolaou N. The radiobiological P(+) index for pretreatment plan assessment with emphasis on four-dimensional radiotherapy modalities. Med Phys. 2012 Oct; 39(10):6420-30.
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  35. Qiu H, Wild AT, Wang H, Fishman EK, Hruban RH, Laheru DA, Kumar R, Hacker-Prietz A, Tuli R, Tryggestad E, Schulick RD, Cameron JL, Edil BH, Pawlik TM, Wolfgang CL, Herman JM. Comparison of conventional and 3-dimensional computed tomography against histopathologic examination in determining pancreatic adenocarcinoma tumor size: implications for radiation therapy planning. Radiother Oncol. 2012 Aug; 104(2):167-72. Epub 2012 Aug 8
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  36. Wang S, Tryggestad E, Zhou T, Armour M, Wen Z, Fu DX, Ford E, van Zijl PC, Zhou J. Assessment of MRI parameters as imaging biomarkers for radiation necrosis in the rat brain. Int J Radiat Oncol Biol Phys. 2012 Jul 1; 83(3):e431-6. Epub 2012 Apr 05.
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  37. Tuli R, Surmak A, Reyes J, Hacker-Prietz A, Armour M, Leubner A, Blackford A, Tryggestad E, Jaffee EM, Wong J, Deweese TL, Herman JM. Development of a novel preclinical pancreatic cancer research model: bioluminescence image-guided focal irradation and tumor monitoring of orthotopic xenografts Transl Oncol. 2012 Apr; 5(2):77-84.
  38. Wang S, Chen Y, Lal B, Ford E, Tryggestad E, Armour M, Yan K, Laterra J, Zhou J. Evaluation of radiation necrosis and malignant glioma in rat models using diffusion tensor MR imaging. J Neurooncol. 2012 Mar; 107(1):51-60. Epub 2011 Sep 27.
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  39. Roland T, Hales R, McNutt T, Wong J, Simari P, Tryggestad E. A method for deriving a 4D-interpolated balanced planning target for mobile tumor radiotherapy. Med Phys. 2012 Jan; 39(1):195-205.
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  40. Redmond KJ, Achanta P, Grossman SA, Armour M, Reyes J, Kleinberg L, Tryggestad E, Quinones-Hinojosa A, Ford EC. A radiotherapy technique to limit dose to neural progenitor cell niches without compromising tumor coverage. J Neurooncol. 2011 Sep; 104: (2)579-87.
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  41. Verhaegen F, Granton P, Tryggestad E. Small animal radiotherapy research platforms. Phys Med Biol. 2011 Jun 21; 56(12):R55-83. Epub 2011 May 26
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  42. Tryggestad E, Christian M, Ford E, Kut C, Le Y, Sanguineti G, Song DY, Kleinberg L. Inter- and intrafraction patient positioning uncertainties for intracranial radiotherapy: a study of four frameless, thermoplastic mask-based immobilization strategies using daily cone-beam CT. Int J Radiat Oncol Biol Phys. 2011 May 1; 80(1):281-90. Epub 2010 Oct 15.
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  43. Cao X, Wu X, Frassica D, Yu B, Pang L, Xian L, Wan M, Lei W, Armour M, Tryggestad E, Wong J, Wen CY, Lu WW, Frassica FJ. Irradiation induces bone injury by damaging bone marrow microenvironment for stem cells. Proc Natl Acad Sci U S A. 2011 Jan 25; 108(4):1609-14. Epub 2011 Jan 10.
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  44. Zhou J, Tryggestad E, Wen Z, Lal B, Zhou T, Grossman R, Wang S, Yan K, Fu DX, Ford E, Tyler B, Blakeley J, Laterra J, van Zijl PC. Differentiation between glioma and radiation necrosis using molecular magnetic resonance imaging of endogenous proteins and peptides. Nat Med. 2011 Jan; 17(1):130-4. Epub 2010 Dec 19.
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  45. Tryggestad E, Armour M, Iordachita I, Verhaegen F, Wong JW. A comprehensive system for dosimetric commissioning and Monte Carlo validation for the small animal radiation research platform. Phys Med Biol. 2009 Sep 7; 54(17):5341-57. Epub 2009 Aug 18.
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  46. Ford E, Purger D, Tryggestad E, McNutt T, Christodouleas J, Rigamonti D, Shokek O, Won S, Zhou J, Lim M, Wong J, Kleinberg L. A virtual frame system for stereotactic radiosurgery planning. Int J Radiat Oncol Biol Phys. 2008 Nov 15; 72(4):1244-9.
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  47. Wong J, Armour E, Kazanzides P, Iordachita I, Tryggestad E, Deng H, Matinfar M, Kennedy C, Liu Z, Chan T, Gray O, Verhaegen F, McNutt T, Ford E, DeWeese TL. High-resolution, small animal radiation research platform with x-ray tomographic guidance capabilities. Int J Radiat Oncol Biol Phys. 2008 Aug 1; 71(5):1591-9.
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  48. Duan W, Peng Q, Masuda N, Ford E, Tryggestad E, Ladenheim B, Zhao M, Cadet JL, Wong J, Ross CA. Sertraline slows disease progression and increases neurogenesis in N171-82Q mouse model of Huntington's disease. Neurobiol Dis. 2008 Jun; 30(3):312-22. Epub 2008 Mar 10.
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  49. Deng H, Kennedy CW, Armour E, Tryggestad E, Ford E, McNutt T, Jiang L, Wong J. The small-animal radiation research platform (SARRP): dosimetry of a focused lens system. Phys Med Biol. 2007 May 21; 52(10):2729-40. Epub 2007 Apr 26.
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  50. Karikari CA, Roy I, Tryggestad E, Feldmann G, Pinilla C, Welsh K, Reed JC, Armour EP, Wong J, Herman J, Rakheja D, Maitra A. Targeting the apoptotic machinery in pancreatic cancers using small-molecule antagonists of the X-linked inhibitor of apoptosis protein. Mol Cancer Ther. 2007 Mar; 6(3):957-66. Epub 2007 Mar 05.
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  51. Gaudefroy L, Sorlin O, Beaumel D, Blumenfeld Y, Dombradi Z, Fortier S, Franchoo S, Gelin M, Gibelin J, Grevy S, Hammache F, Ibrahim F, Kemper KW, Kratz KL, Lukyanov SM, Monrozeau C, Nalpas L, Nowacki F, Ostrowski AN, Otsuka T, Penionzhkevich YE, Piekarewicz J, Pollacco EC, Roussel-Chomaz P, Rich E, Scarpaci JA, St Laurent MG, Sohler D, Stanoiu M, Suzuki T, Tryggestad E, Verney D. Reduction of the spin-orbit splittings at the n = 28 shell closure. Phys Rev Lett. 2006 Sep 1; 97(9):092501. Epub 2006 Aug 30.
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  52. Shrivastava A, Blumenfeld Y, Keeley N, Zerguerras T, Aumann T, Bazin D, Chromik M, Crawley G, Glasmacher T, Kemper K, Marechal F, Morrissey D, Nakamura T, Navin A, Pollacco E, Santonocito D, Sherrill B, Suomijarvi T, Thoennessen M, Tryggestad E, Varner R. 11Be continuum studied through proton scattering. Phys Lett B. 2004; 596:54.
  53. Navin A, Tripathi V, Blumenfeld Y, Nanal V, Simenel C, Casandjian JM, de France G, Raabe R, Bazin D, Chatterjee A, Dasgupta M, Kailas S, Lemmon RC, Mahata K, Pillay RG, Pollacco EC, Ramachandran K, Rejmund M, Shrivastava A, Sida JH, Tryggestad E. Direct and compound reactions induced by unstable helium beams near the Coulomb barrier. Phys Rev C. 2004; 70:044601.
  54. Heckman P, Bazin D, Beene J, Blumenfeld Y, Chromik M, Halbert M, Liang J, Mohrmann E, Nakamura T, Navin A, Sherrill B, Snover K, Thoennessen M, Tryggestad E, Varner R. Low-temperature measurement of the giant dipole resonance width. Phys Lett B. 2003; 555:43.
  55. Enders J, Baumann T, Brown B, Frank N, Hansen P, Heckman P, Sherrill B, Stolz A, Thoennessen M, Tostevin J, Tryggestad E, Typel S, Wallace M. Spectroscopic factors measured in inclusive proton-knockout reactions on 8B and 9C at intermediate energies. Phys Rev C. 2003; 67:064301.
  56. Tryggestad E, Baumann T, Heckman P, Thoennessen M, Aumann T, Bazin D, Blumenfeld Y, Beene J, Lewis T, Radford D, Shapira D, Varner R, Chartier M, Halbert M, Liang J. Low-lying E1 strength in 20O. Phys Rev C. 2003; 67:064309.
  57. Peters W, Baumann T, Bazin D, Brown B, Clement R, Frank N, Heckman P, Luther B, Nunes F, Seitz J, Stolz A, Thoennessen M, Tryggestad E. First two energy levels in 15F. Phys Rev C. 2003; 68:034607.
  58. Thoennessen M, Baumann T, Brown B, Enders J, Frank N, Hansen P, Heckman P, Luther B, Seitz J, Stolz A, Tryggestad E. Single proton knock-out reactions from 24,25,26F. Phys Rev C. 2003; 68:044318.
  59. Kruse JJ, Galonsky A, Snow C, Tryggestad E, Wang J, Ieki K, Iwata Y, Zecher PD. Fragment detection system for studies of exotic neutron-rich nuclei. Nucl Instrum Methods Phys Res A. 2002 Mar 21; 480(2-3):598-609.
  60. Wang J, Galonsky A, Kruse JJ, Tryggestad E, White-Stevens RH, Zecher PD, Iwata Y, Ieki K, Horváth A, Deák F, Kiss A, Seres Z, Kolata JJ, von Schwarzenberg J, Warner RE, Schelin H. Dissociation of 6He. Physical Review C. 2002 Mar; 65(3):034306.
  61. Chromik M, Thirolf P, Thoennessen M, Brown B, Davinson T, Gassmann D, Heckman P, Prisciandaro J, Reiter P, Tryggestad E, Woods P. Two proton spectroscopy of low-lying states in 17Ne. Phys Rev C. 2002; 66:024313.
  62. Tryggestad E, Aumann T, Baumann T, Bazin D, Beene J, Blumenfeld Y, Brown B, Chartier M, Halbert M, Heckman P, Liang J, Radford D, Shapira D, Thoennessen M, Varner R. Low-lying dipole strength in 20O. Phys Lett B. 2002; 541:52.
  63. Markenroth K, Axelsson L, Baxter S, Borge M, Donzaud C, Fayans S, Fynbo H, Goldberg H, Grevy S, Guillemaud-Mueller D, Jonson B, Kallman K, Leenhardt S, Lewitowicz M, Lonnroth T, Manngard P, Martel I, Mueller A, Mukha I, Nilsson T, NymanG, Orr N, Riisager K, Rogachev G, Saint-Laurent M, Serikov I, Shulgina N, Sorlin O, Steiner M, Tengblad O, Thoennessen M, Tryggestad E, Trzaska W, Wenander F, Winfield J, Wolski R. Crossing the Dripline to 11N using Elastic Resonance Scattering. Phys Rev C. 2000; 62:034308.
  64. Iwata Y, Ieki K, Galonsky A, Kruse J, Wang J, White-Stevens R, Tryggestad E, Zecher P, Deak F, Horvath A, Kiss A, Seres Z, Kolata J, Schwarzenberg J, Warner R, Schelin H. Dissociation of 8He. Phys Rev C. 2000; 62:064311.
  65. Zecher P, Galonsky A, Gaff S, Kruse J, Kunde G, Tryggestad E, Wang J, Warner R, Morrissey D, Ieki K, Iwata Y, Deak F, Horvath A, Kiss A, Seres Z, Kolata J, Schwarzenberg J, Schelin H. Measurement of the 8Li(n,γ)9Li cross section at astrophysical energies by reverse kinematics. Phys Rev C. 1998; 57:959.
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