Leigh L. Speicher, M.D., M.P.H.

  1. Aerospace Medicine Specialist
  2. Internist

Publications

  1. Johnson PW, Kunze KL, Senefeld JW, Sinclair JE, Isha S, Satashia PH, Bhakta S, Cowart JB, Bosch W, O'Horo J, Shah SZ, Wadei HM, Edwards MA, Pollock BD, Edwards AJ, Scheitel-Tulledge S, Clune CG, Hanson SN, Arndt R, Heyliger A, Kudrna C, Bierle DM, Buckmeier JR, Seville MTA, Orenstein R, Libertin C, Ganesh R, Franco PM, Razonable RR, Carter RE, Sanghavi DK, Speicher LL. Association of Neutralizing Anti-spike Monoclonal Antibody Treatment With COVID-19 Hospitalization and Assessment of the Monoclonal Antibody Screening Score. Mayo Clin Proc Innov Qual Outcomes. 2023 Jan 11 [Epub ahead of print]
    View PubMed
  2. Speicher LL, Francis D. Improving Employee Experience: Reducing Burnout, Decreasing Turnover and Building Well-being. Clin Gastroenterol Hepatol. 2023 Jan; 21 (1):11-14 Epub 2022 Sept 22
    View PubMed
  3. Haddad TC, Coffey JD, Deng Y, Glasgow AE, Christopherson LA, Sangaralingham LR, Bell SJ, Shah VP, Pritchett JC, Orenstein R, Speicher LL, Maniaci MJ, Ganesh R, Borah BJ. Impact of a High-Risk, Ambulatory COVID-19 Remote Patient Monitoring Program on Utilization, Cost, and Mortality. Mayo Clin Proc. 2022 Dec; 97 (12):2215-2225 Epub 2022 Sept 06
    View PubMed
  4. Razonable RR, O'Horo JC, Hanson SN, Arndt RF, Speicher LL, Seville TA, Hall ST, Pike ML, Heyliger A, Larsen JJ, Ganesh R, Tulledge-Scheitel SM. Comparable Outcomes for Bebtelovimab and Ritonavir-Boosted Nirmatrelvir Treatment in High-Risk Patients With Coronavirus Disease-2019 During Severe Acute Respiratory Syndrome Coronavirus 2 BA.2 Omicron Epoch. J Infect Dis. 2022 Nov 11; 226 (10):1683-1687
    View PubMed
  5. Yetmar ZA, O'Horo JC, Seville MT, Speicher LL, Ganesh R, Razonable RR. Outcomes of Solid Organ Transplant Recipients Treated With Antispike Monoclonal Antibodies for Coronavirus Disease 2019 Across Variant Epochs: Impact of Comorbidities and Vaccination. Transplantation 2022 Nov 1; 106 (11):e507-e509 Epub 2022 Aug 15
    View PubMed
  6. Razonable RR, Tulledge-Scheitel SM, Hanson SN, Arndt RF, Speicher LL, Seville TA, Larsen JJ, Ganesh R, O'Horo JC. Real-world Clinical Outcomes of Bebtelovimab and Sotrovimab Treatment of High-risk Persons With Coronavirus Disease 2019 During the Omicron Epoch. Open Forum Infect Dis. 2022 Oct; 9 (10):ofac411 Epub 2022 Oct 06
    View PubMed
  7. Bosch W, Cowart JB, Bhakta S, Carter RE, Wadei HM, Shah SZ, Sanghavi DK, Pollock BD, Neville MR, Oman SP, Speicher L, Scindia AD, Matson MW, Moreno Franco P. Coronavirus Disease 2019 Vaccine-Breakthrough Infections Requiring Hospitalization in Mayo Clinic Florida Through August 2021. Clin Infect Dis. 2022 Aug 24; 75 (1):e892-e894
    View PubMed
  8. Puranik A, Lenehan PJ, O'Horo JC, Pawlowski C, Niesen MJM, Virk A, Swift MD, Kremers W, Venkatakrishnan AJ, Gordon JE, Geyer HL, Speicher LL, Soundararajan V, Badley AD. Durability analysis of the highly effective BNT162b2 vaccine against COVID-19. PNAS Nexus. 2022 Jul; 1 (3):pgac082 Epub 2022 June 08
    View PubMed
  9. Pawlowski C, Silvert E, O'Horo JC, Lenehan PJ, Challener D, Gnass E, Murugadoss K, Ross J, Speicher L, Geyer H, Venkatakrishnan AJ, Badley AD, Soundararajan V. SARS-CoV-2 and influenza coinfection throughout the COVID-19 pandemic: an assessment of coinfection rates, cohort characteristics, and clinical outcomes. PNAS Nexus. 2022 Jul; 1 (3):pgac071 Epub 2022 July 04
    View PubMed
  10. Sanghavi DK, Bhakta S, Wadei HM, Bosch W, Cowart JB, Carter RE, Shah SZ, Pollock BD, Neville MR, Oman SP, Speicher L, Siegel J, Scindia AD, Libertin CR, Kunze KL, Johnson PW, Matson MW, Franco PM. Low antispike antibody levels correlate with poor outcomes in COVID-19 breakthrough hospitalizations. J Intern Med. 2022 Jul; 292 (1):127-135 Epub 2022 Mar 24
    View PubMed
  11. Bhakta S, Sanghavi DK, Johnson PW, Kunze KL, Neville MR, Wadei HM, Bosch W, Carter RE, Shah SZ, Pollock BD, Oman SP, Speicher L, Siegel J, Libertin CR, Matson MW, Moreno Franco P, Cowart JB. Clinical and laboratory profiles of the SARS-CoV-2 Delta variant compared with pre-Delta variants. Int J Infect Dis. 2022 Jul; 120:88-95 Epub 2022 Apr 26
    View PubMed
  12. Puranik A, Lenehan PJ, O'Horo JC, Pawlowski C, Virk A, Swift MD, Kremers W, Venkatakrishnan AJ, Challener DW, Breeher L, Gordon JE, Geyer HL, Speicher LL, Soundararajan V, Badley AD. Durability analysis of the highly effective mRNA-1273 vaccine against COVID-19. PNAS Nexus. 2022 May; 1 (2):pgac058 Epub 2022 May 20
    View PubMed
  13. Niesen MJM, Matson R, Puranik A, O'Horo JC, Pawlowski C, Vachon C, Challener D, Virk A, Swift M, Speicher L, Gordon J, Geyer H, Lenehan PJ, Venkatakrishnan AJ, Soundararajan V, Badley A. Third dose vaccination with mRNA-1273 or BNT162b2 vaccines improves protection against SARS-CoV-2 infection. PNAS Nexus. 2022 May; 1 (2):pgac042 Epub 2022 Apr 28
    View PubMed
  14. Niesen, Matson R, Puranik A, O'Horo JC, Pawlowski C, Vachon C, Challener D, Virk A, Swift MD, Speicher L, Gordon J, Geyer H, Lenehan PJ, Venkatakrishnan AJ, Soundararajan V, Badley A. Third dose vaccination with mRNA-1273 or BNT162b2 vaccines improves protection against SARS-CoV-2 infection Proceedings of the National Academy of Sciences (PNAS) Nexus. 2022; 1(2):pgac042.
  15. Niesen MJM, Pawlowski C, O'Horo JC, Challener DW, Silvert E, Donadio G, Lenehan PJ, Virk A, Swift MD, Speicher LL, Gordon JE, Geyer HL, Halamka JD, Venkatakrishnan AJ, Soundararajan V, Badley AD. Surveillance of Safety of 3 Doses of COVID-19 mRNA Vaccination Using Electronic Health Records. JAMA Netw Open. 2022 Apr 1; 5 (4):e227038 Epub 2022 Apr 01
    View PubMed
  16. O'Horo JC, Challener DW, Speicher L, Bosch W, Seville MT, Bierle DM, Ganesh R, Wilker CG, Arndt RF, Arndt LL, Tulledge-Scheitel SM, Hanson SN, Razonable RR. Effectiveness of Monoclonal Antibodies in Preventing Severe COVID-19 With Emergence of the Delta Variant. Mayo Clin Proc. 2022 Feb; 97 (2):327-332 Epub 2021 Dec 16
    View PubMed
  17. Puranik A, Lenehan PJ, Silvert E, Niesen MJM, Corchado-Garcia J, O'Horo JC, Virk A, Swift MD, Gordon JE, Speicher LL, Geyer HL, Kremers W, Halamka J, Badley AD, Venkatakrishnan AJ, Soundararajan V. Comparative effectiveness of mRNA-1273 and BNT162b2 against symptomatic SARS-CoV-2 infection. Med (N Y). 2022 Jan 14; 3 (1):28-41.e8 Epub 2021 Dec 11
    View PubMed
  18. Bosch W, Cowart JB, Bhakta S, Carter RE, Wadei HM, Shah SZ, Sanghavi DK, Pollock BD, Neville MR, Oman SP, Speicher L, Scindia AD, Matson MW, Moreno Franco P. Coronavirus disease 2019 vaccine-breakthrough infections requiring hospitalization in Mayo Clinic Florida through August 2021. Clinical Infectious Diseases. 2022; 75 (1):e892-4
  19. Ganesh R, Philpot LM, Bierle DM, Anderson RJ, Arndt LL, Arndt RF, Culbertson TL, Destro Borgen MJ, Hanson SN, Kennedy BD, Kottke BB, Larsen JJ, Ramar P, Rosedahl JK, Seville MT, Speicher LL, Tulledge-Scheitel SM, Wilker CG, Razonable RR. Real-World Clinical Outcomes of Bamlanivimab and Casirivimab-Imdevimab Among High-Risk Patients With Mild to Moderate Coronavirus Disease 2019. J Infect Dis. 2021 Oct 28; 224 (8):1278-1286
    View PubMed
  20. Ganesh R, Pawlowski CF, O'Horo JC, Arndt LL, Arndt RF, Bell SJ, Bierle DM, Borgen MD, Hanson SN, Heyliger A, Larsen JJ, Lenehan PJ, Orenstein R, Puranik A, Speicher LL, Tulledge-Scheitel SM, Venkatakrishnan AJ, Wilker CG, Badley AD, Razonable RR. Intravenous bamlanivimab use associates with reduced hospitalization in high-risk patients with mild to moderate COVID-19. J Clin Invest. 2021 Oct 1; 131 (19)
    View PubMed
  21. Razonable RR, Pawlowski C, O'Horo JC, Arndt LL, Arndt R, Bierle DM, Borgen MD, Hanson SN, Hedin MC, Lenehan P, Puranik A, Seville MT, Speicher LL, Tulledge-Scheitel SM, Venkatakrishnan AJ, Wilker CG, Badley AD, Ganesh R. Casirivimab-Imdevimab treatment is associated with reduced rates of hospitalization among high-risk patients with mild to moderate coronavirus disease-19. EClinicalMedicine. 2021 Oct; 40:101102 Epub 2021 Aug 30
    View PubMed
  22. Pritchett JC, Borah BJ, Desai AP, Xie Z, Saliba AN, Leventakos K, Coffey JD, Pearson KK, Speicher LL, Orenstein R, Virk A, Ganesh R, Paludo J, Halfdanarson TR, Haddad TC. Association of a Remote Patient Monitoring (RPM) Program With Reduced Hospitalizations in Cancer Patients With COVID-19. JCO Oncol Pract. 2021 Sep; 17 (9):e1293-e1302 Epub 2021 June 04
    View PubMed
  23. Bosch W, Cowart J, Bhakta SN, Carter RE, Sanghavi DK, Pollock B, Neville MR, Matson MW, Oman SP, Speicher L, Scindia AD, Moreno Franco P. Vaccine-Breakthrough COVID-19 Infections Requiring Hospitalization in Florida through July 2021 (Letter) Mayo Clinic Proceedings. 2021.
  24. Coffey JD, Christopherson LA, Glasgow AE, Pearson KK, Brown JK, Gathje SR, Sangaralingham LR, Carmona Porquera EM, Virk A, Orenstein R, Speicher LL, Bierle DM, Ganesh R, Cox DL, Blegen RN, Haddad TC. Implementation of a multisite, interdisciplinary remote patient monitoring program for ambulatory management of patients with COVID-19. NPJ Digit Med. 2021 Aug 13; 4 (1):123
    View PubMed
  25. Tolaymat LM, Reimer DK, Feig J, Gillis MS, Speicher LL, Haga CB, Gabriel EM, Heckman MG, Yin M, Fosko SW, Keaveny AP, Dawson NL. Skin cancer in non-white liver transplant recipients: Mayo Clinic experience. Int J Dermatol. 2021 Aug; 60(8):986-990. Epub 2021 Mar 20.
    View PubMed
  26. Ton A, Francis D, Speicher L. COVID-19 Patient Acceptance to Monoclonal Antibody Infusion: A Single Medical Center Experience. South Med J 2021 Aug; 114 (8):464
    View PubMed
  27. Razonable RR, Aloia NCE, Anderson RJ, Anil G, Arndt LL, Arndt RF, Ausman SE, Bell SJ, Bierle DM, Billings ML, Bishop RK, Cramer CH, Culbertson TL, Dababneh AS, Derr AN, Epps K, Flaker SM, Ganesh R, Gilmer MA, Urena EG, Gulden CR, Haack TL, Hanson SN, Herzog JR, Heyliger A, Hokanson LD, Hopkins LH, Horecki RJ, Krishna BH, Huskins WC, Jackson TA, Johnson RR, Jorgenson B, Kudrna C, Kennedy BD, Klingsporn MK, Kottke B, Larsen JJ, Lessard SR, Lutwick LI, Malone EJ 3rd, Matoush JA, Micallef IN, Moehnke DE, Mohamed M, Ness CN, Olson SM, Orenstein R, Palraj R, Patel J, Paulson DJ, Phelan D, Peinovich MT, Ramsey WL, Rau-Kane TJ, Reid KI, Reinschmidt KJ, Seville MT, Skold EC, Smith JM, Speicher LL, Spielman LA, Springer DJ, Sweeten PW, Tempelis JM, Tulledge-Scheitel S, Vergidis P, Whipple DC, Wilker CG, Destro Borgen MJ. A Framework for Outpatient Infusion of Antispike Monoclonal Antibodies to High-Risk Patients with Mild-to-Moderate Coronavirus Disease-19: The Mayo Clinic Model. Mayo Clin Proc. 2021 May; 96 (5):1250-1261 Epub 2021 Mar 09
    View PubMed
  28. O'Horo JC, Cerhan JR, Cahn EJ, Bauer PR, Temesgen Z, Ebbert J, Abril A, Abu Saleh OM, Assi M, Berbari EF, Bierle DM, Bosch W, Burger CD, Cano Cevallos EJ, Clements CM, Carmona Porquera EM, Castillo Almeida NE, Challener DW, Chesdachai S, Comba IY, Corsini Campioli CG, Crane SJ, Dababneh AS, Enzler MJ, Fadel HJ, Ganesh R, De Moraes AG, Go JR, Gordon JE, Gurram PR, Guru PK, Halverson EL, Harrison MF, Heaton HA, Hurt R, Kasten MJ, Lee AS, Levy ER, Libertin CR, Mallea JM, Marshall WF 3rd, Matcha G, Meehan AM, Franco PM, Morice WG 2nd, O'Brien JJ, Oeckler R, Ommen S, Oravec CP, Orenstein R, Ough NJ, Palraj R, Patel BM, Pureza VS, Pickering B, Phelan DM, Razonable RR, Rizza S, Sampathkumar P, Sanghavi DK, Sen A, Siegel JL, Singbartl K, Shah AS, Shweta F, Speicher LL, Suh G, Tabaja H Jr, Tande A, Ting HH, Tontz RC 3rd, Vaillant JJ, Vergidis P, Warsame MY, Yetmar ZA, Zomok CCD, Williams AW, Badley AD. Outcomes of COVID-19 With the Mayo Clinic Model of Care and Research. Mayo Clin Proc. 2021 Mar; 96(3):601-618. Epub 2020 Dec 26.
    View PubMed
  29. Speicher L, Crosby S, Schuh MJ. Pharmacogenomics Testing Confirmation of Carbamazepine Induced DRESS Reaction of an HLA-A*31:01 Positive, Polypharmacy Patient. Innov Pharm. 2021; 12 (4) Epub 2021 Sept 22
    View PubMed
  30. Knight D, Downes K, Munipalli B, Halkar MG, Logvinov II, Speicher LL, Hines SL. Symptoms and Clinical Outcomes of Coronavirus Disease 2019 in the Outpatient Setting. SN Compr Clin Med. 2021; 3 (1):247-254 Epub 2021 Jan 14
    View PubMed
  31. Jethwa T, Ton A, Paredes Molina CS, Speicher L, Walsh K, Knight D, Davlantes T, Francis D. Establishing Mayo Clinic's Coronavirus Disease 2019 Virtual Clinic: A Preliminary Communication. Telemed J E Health. 2020 Nov; 26 (11):1419-1423 Epub 2020 June 09
    View PubMed
  32. Huang K, Misra S, Lemini R, Chen Y, Speicher LL, Dawson NL, Tolaymat LM, Bagaria SP, Gabriel EM. Completion lymph node dissection in patients with sentinel lymph node positive cutaneous head and neck melanoma. J Surg Oncol. 2020 Nov; 122 (6):1057-1065 Epub 2020 July 11
    View PubMed
  33. Koop AH, Cowdell J, Patel N, Kesler A, Mwakyanjala E, Heckman A, Padmanabhan Menon D, Patel N, Narciso P, Reid A, Decicco N, Speicher L. Intravenous Access in Gastrointestinal Hemorrhage: A Multidisciplinary Quality Improvement Initiative Led by Emergency Department Nurses and Internal Medicine Physicians. J Nurs Care Qual. 2020 Jul/Sep; 35 (3):E41-E46
    View PubMed
  34. Koop AH, Cowdell J, Patel N, Kesler A, Mwakyanjala E, Heckman A, Padmanabhan Menon D, Patel N, Narciso P, Reid A, Decicco N, Speicher L. Intravenous Access in Gastrointestinal Hemorrhage: A Multidisciplinary Quality Improvement Initiative Led by Emergency Department Nurses and Internal Medicine Physicians. J Nurs Care Qual. 2019 Nov 14 [Epub ahead of print]
    View PubMed
  35. Speicher L , Blue R. S , Vanderploeg J.. Vehicle Restraint Consideration for Commercial Spaceflight New Space. 2019. Epub 2019 Feb 27.
PST-20226952