Publications Print Li DK, Pu Y, Liu Y, You K, Nanna MG, Harris A, Sung JJY, Laine L, Shung DL. Antiplatelet Resumption Timing in Post-Percutaneous Coronary Intervention Gastrointestinal Bleeding. Aliment Pharmacol Ther. 2026 Mar 19 [Epub ahead of print] View PubMed Chung S, Saberzadeh-Ardestani B, Nigam G, Yuan Y, Singh S, Shung D. Large Language Model-Supported Systematic Reviews to Augment Clinical Guideline Development: An American Gastroenterological Association Pilot. Gastroenterology. 2025 Sep; 169 (4):715-717 Epub 2025 Apr 06 View PubMed Chung S, Giuffre M, Rajashekar N, Pu Y, Shin YE, Kresevic S, Chan C, Nakamura-Sakai S, You K, Saarinen T, Hsiao A, Wong AH, Evans L, McCall T, Kizilcec RF, Sekhon J, Laine L, Shung DL. Usability and adoption in a randomized trial of GutGPT a GenAI tool for gastrointestinal bleeding. NPJ Digit Med. 2025 Aug 18; 8 (1):527 View PubMed Shung DL, Iacucci M. Artificial Intelligence in Gastroenterology and Hepatology: Potential and Perils. Gastroenterology. 2025 Aug; 169 (3):391-392 Epub 2025 May 13 View PubMed Soroush A, Giuffre M, Chung S, Shung DL. Generative Artificial Intelligence in Clinical Medicine and Impact on Gastroenterology. Gastroenterology. 2025 Aug; 169 (3):502-517.e1 Epub 2025 Apr 15 View PubMed Caminero A, Tropini C, Valles-Colomer M, Shung DL, Gibbons SM, Surette MG, Sokol H, Tomeo NJ, Tarr PI, Verdu EF, Scientific Advisory Board of the Center for Gut Microbiome Research and Education of the American Gastroenterological Association. Credible inferences in microbiome research: ensuring rigour, reproducibility and relevance in the era of AI. Nat Rev Gastroenterol Hepatol. 2025 Jul 31 Epub 2025 July 31 View PubMed Giuffre M, You K, Pang Z, Kresevic S, Chung S, Chen R, Ko Y, Chan C, Saarinen T, Ajcevic M, Croce LS, Garcia-Tsao G, Gralnek I, Sung JJY, Barkun A, Laine L, Sekhon J, Stadie B, Shung DL. Expert of Experts Verification and Alignment (EVAL) Framework for Large Language Models Safety in Gastroenterology. NPJ Digit Med. 2025 May 3; 8 (1):242 Epub 2025 May 03 View PubMed Sultan S, Shung DL, Kolb JM, Foroutan F, Hassan C, Kahi CJ, Liang PS, Levin TR, Siddique SM, Lebwohl B. AGA Living Clinical Practice Guideline on Computer-Aided Detection-Assisted Colonoscopy. Gastroenterology. 2025 Apr; 168 (4):691-700 View PubMed Giuffre M, Dupont J, Visintin A, Masutti F, Monica F, You K, Shung DL, Croce LS, NSBB-Elasto-Response-Prediction Group. Predicting response to non-selective beta-blockers with liver-spleen stiffness and heart rate in patients with liver cirrhosis and high-risk varices. Hepatol Int. 2025 Apr; 19 (2):460-471 Epub 2024 Apr 25 View PubMed Giuffre M, Dupont J, Visintin A, Masutti F, Monica F, You K, Shung DL, Croce LS, NSBB-Elasto-Response-Prediction Group. Predicting response to non-selective beta-blockers with liver-spleen stiffness and heart rate in patients with liver cirrhosis and high-risk varices. Hepatol Int. 2025 Apr; 19 (2):460-471 Epub 2024 Apr 25 View PubMed Foroutan F, Vandvik PO, Helsingen LM, Kalager M, Rutter M, Selby K, Pilonis ND, Anderson JC, McKinnon A, Fuchs JM, Quinlan C, Buskermolen M, Senore C, Wang P, Sung JJY, Haug U, Bjerkelund S, Triantafyllou K, Shung DL, Halvorsen N, McGinn T, Hafver TL, Reinthaler V, Guyatt G, Agoritsas T, Sultan S. Computer aided detection and diagnosis of polyps in adult patients undergoing colonoscopy: a living clinical practice guideline. BMJ. 2025 Mar 27; 388:e082656 View PubMed Xie Q, Chen Q, Chen A, Peng C, Hu Y, Lin F, Peng X, Huang J, Zhang J, Keloth V, Zhou X, Qian L, He H, Shung D, Ohno-Machado L, Wu Y, Xu H, Bian J. Medical foundation large language models for comprehensive text analysis and beyond. NPJ Digit Med. 2025 Mar 5; 8 (1):141 Epub 2025 Mar 05 View PubMed Silverman AL, Shung D, Stidham RW, Kochhar GS, Iacucci M. How Artificial Intelligence Will Transform Clinical Care, Research, and Trials for Inflammatory Bowel Disease. Clin Gastroenterol Hepatol. 2025 Feb; 23 (3):428-439.e4 Epub 2024 July 09 View PubMed Zheng NS, Keloth VK, You K, Kats D, Li DK, Deshpande O, Sachar H, Xu H, Laine L, Shung DL. Detection of Gastrointestinal Bleeding With Large Language Models to Aid Quality Improvement and Appropriate Reimbursement. Gastroenterology. 2025 Jan; 168 (1):111-120.e4 Epub 2024 Sept 18 View PubMed You K, Shung D, Giuffre M. On the Wasserstein Median of Probability Measures. J Comput Graph Stat. 2025; 34 (1):253-266 Epub 2024 Aug 29 View PubMed Burton SJ, Shung D, Chung S, Aslanian H. Patient Perspective of Use of Artificial Intelligence During Colonoscopy. Gastro Hep Adv. 2025; 4 (1):100543 Epub 2024 Sept 02 View PubMed Soleymanjahi S, Huebner J, Elmansy L, Rajashekar N, Ludtke N, Paracha R, Thompson R, Grimshaw AA, Foroutan F, Sultan S, Shung DL. Artificial Intelligence-Assisted Colonoscopy for Polyp Detection : A Systematic Review and Meta-analysis. Ann Intern Med. 2024 Dec; 177 (12):1652-1663 Epub 2024 Oct 22 View PubMed Shung DL, Chan CE, You K, Nakamura S, Saarinen T, Zheng NS, Simonov M, Li DK, Tsay C, Kawamura Y, Shen M, Hsiao A, Sekhon JS, Laine L. Validation of an Electronic Health Record-Based Machine Learning Model Compared With Clinical Risk Scores for Gastrointestinal Bleeding. Gastroenterology. 2024 Nov; 167 (6):1198-1212 Epub 2024 July 05 View PubMed Giuffre M, Kresevic S, Pugliese N, You K, Shung DL. Optimizing large language models in digestive disease: strategies and challenges to improve clinical outcomes. Liver Int. 2024 Sep; 44 (9):2114-2124 Epub 2024 May 31 View PubMed Giuffre M, Kresevic S, You K, Dupont J, Huebner J, Grimshaw AA, Shung DL. Systematic review: The use of large language models as medical chatbots in digestive diseases. Aliment Pharmacol Ther. 2024 Jul; 60 (2):144-166 Epub 2024 May 27 View PubMed Shung DL, Laine L. Review article: Upper gastrointestinal bleeding - review of current evidence and implications for management. Aliment Pharmacol Ther. 2024 May; 59 (9):1062-1081 Epub 2024 Mar 22 View PubMed Kresevic S, Giuffre M, Ajcevic M, Accardo A, Croce LS, Shung DL. Optimization of hepatological clinical guidelines interpretation by large language models: a retrieval augmented generation-based framework. NPJ Digit Med. 2024 Apr 23; 7 (1):102 View PubMed Shung DL, Lin JK, Laine L. Achieving Value by Risk Stratification With Machine Learning Model or Clinical Risk Score in Acute Upper Gastrointestinal Bleeding: A Cost Minimization Analysis. Am J Gastroenterol. 2024 Feb 1; 119 (2):371-373 Epub 2023 Nov 23 View PubMed Zheng NS, Ma W, Shung DL, Strate LL, Chan AT. Sex, Race, and Ethnicity Differences in Patients Presenting With Diverticular Disease at Emergency Departments in the United States: A National Cross-Sectional Study. Gastro Hep Adv. 2024; 3 (2):178-180 Epub 2023 Nov 27 View PubMed Li DK, Laine L, Shung DL. Trends in Upper Gastrointestinal Bleeding in Patients on Primary Prevention Aspirin: A Nationwide Emergency Department Sample Analysis, 2016-2020. Am J Med. 2023 Dec; 136 (12):1179-1186.e1 Epub 2023 Sept 09 View PubMed Giuffre M, Shung DL. Harnessing the power of synthetic data in healthcare: innovation, application, and privacy. NPJ Digit Med. 2023 Oct 9; 6 (1):186 Epub 2023 Oct 09 View PubMed Rodriguez NJ, Zheng NS, Mezzacappa C, Canavan M, Laine L, Shung DL. Disparities in Access to Endoscopy for Patients With Upper Gastrointestinal Bleeding Presenting to Emergency Departments. Gastroenterology. 2023 Jun; 164 (7):1044-1046.e4 Epub 2022 Oct 10 View PubMed Zheng NS, Shung DL, Kerby EH. Racial and ethnic differences in hospital admissions for cellulitis in the United States: A cross-sectional analysis. J Am Acad Dermatol. 2022 Dec; 87 (6):1413-1416 Epub 2022 Aug 27 View PubMed Zheng NS, Tsay C, Laine L, Shung DL. Trends in characteristics, management, and outcomes of patients presenting with gastrointestinal bleeding to emergency departments in the United States from 2006 to 2019. Aliment Pharmacol Ther. 2022 Dec; 56 (11-12):1543-1555 Epub 2022 Sept 29 View PubMed Plana D, Shung DL, Grimshaw AA, Saraf A, Sung JJY, Kann BH. Randomized Clinical Trials of Machine Learning Interventions in Health Care: A Systematic Review. JAMA Netw Open. 2022 Sep 1; 5 (9):e2233946 Epub 2022 Sept 01 View PubMed Lam TYT, Cheung MFK, Munro YL, Lim KM, Shung D, Sung JJY. Randomized Controlled Trials of Artificial Intelligence in Clinical Practice: Systematic Review. J Med Internet Res. 2022 Aug 25; 24 (8):e37188 View PubMed Tong A, Huguet G, Shung D, Natik A, Kuchroo M, Lajoie G, Wolf G, Krishnaswamy S. EMBEDDING SIGNALS ON GRAPHS WITH UNBALANCED DIFFUSION EARTH MOVER'S DISTANCE. Proc IEEE Int Conf Acoust Speech Signal Process. 2022 May; 2022:5647-5651 Epub 2022 Apr 27 View PubMed Kuchroo M, Huang J, Wong P, Grenier JC, Shung D, Tong A, Lucas C, Klein J, Burkhardt DB, Gigante S, Godavarthi A, Rieck B, Israelow B, Simonov M, Mao T, Oh JE, Silva J, Takahashi T, Odio CD, Casanovas-Massana A, Fournier J, Farhadian S, Dela Cruz CS, Ko AI, Hirn MJ, Wilson FP, Hussin JG, Wolf G, Iwasaki A, Krishnaswamy S, Yale IMPACT Team. Multiscale PHATE identifies multimodal signatures of COVID-19. Nat Biotechnol. 2022 May; 40 (5):681-691 Epub 2022 Feb 28 View PubMed Amodio M, Shung D, Burkhardt DB, Wong P, Simonov M, Yamamoto Y, van Dijk D, Wilson FP, Iwasaki A, Krishnaswamy S. Generating hard-to-obtain information from easy-to-obtain information: Applications in drug discovery and clinical inference. Patterns (N Y). 2021 Jul 9; 2 (7):100288 Epub 2021 June 17 View PubMed Shung D, Tsay C, Laine L, Chang D, Li F, Thomas P, Partridge C, Simonov M, Hsiao A, Tay JK, Taylor A. Early identification of patients with acute gastrointestinal bleeding using natural language processing and decision rules. J Gastroenterol Hepatol. 2021 Jun; 36 (6):1590-1597 Epub 2021 Jan 25 View PubMed Shung D, Huang J, Castro E, Tay JK, Simonov M, Laine L, Batra R, Krishnaswamy S. Neural network predicts need for red blood cell transfusion for patients with acute gastrointestinal bleeding admitted to the intensive care unit. Sci Rep. 2021 Apr 23; 11 (1):8827 View PubMed Shung DL, Sung JJY. Challenges of developing artificial intelligence-assisted tools for clinical medicine. J Gastroenterol Hepatol. 2021 Feb; 36 (2):295-298 View PubMed Shung DL. Advancing care for acute gastrointestinal bleeding using artificial intelligence. J Gastroenterol Hepatol. 2021 Feb; 36 (2):273-278 View PubMed Shen L, Kann BH, Taylor RA, Shung DL. The Clinician's Guide to the Machine Learning Galaxy. Front Physiol. 2021; 12:658583 Epub 2021 Apr 06 View PubMed Shung DL, Byrne MF. How Artificial Intelligence Will Impact Colonoscopy and Colorectal Screening. Gastrointest Endosc Clin N Am. 2020 Jul; 30 (3):585-595 Epub 2020 Apr 11 View PubMed Tsay C, Shung D, Stemmer Frumento K, Laine L. Early Colonoscopy Does Not Improve Outcomes of Patients With Lower Gastrointestinal Bleeding: Systematic Review of Randomized Trials. Clin Gastroenterol Hepatol. 2020 Jul; 18 (8):1696-1703.e2 Epub 2019 Dec 13 View PubMed Shung DL, Au B, Taylor RA, Tay JK, Laursen SB, Stanley AJ, Dalton HR, Ngu J, Schultz M, Laine L. Validation of a Machine Learning Model That Outperforms Clinical Risk Scoring Systems for Upper Gastrointestinal Bleeding. Gastroenterology. 2020 Jan; 158 (1):160-167 Epub 2019 Sept 25 View PubMed Shung D, Simonov M, Gentry M, Au B, Laine L. Machine Learning to Predict Outcomes in Patients with Acute Gastrointestinal Bleeding: A Systematic Review. Dig Dis Sci. 2019 Aug; 64 (8):2078-2087 Epub 2019 May 04 View PubMed Shung DL, Garcia-Tsao G. Liver Capsule: Portal Hypertension and Varices: Pathogenesis, Stages, and Management. Hepatology. 2017 Mar; 65 (3):1038 Epub 2017 Feb 08 View PubMed Shung DL, Abraham B, Sellin J, Hou JK. Medical and surgical complications of inflammatory bowel disease in the elderly: a systematic review. Dig Dis Sci. 2015 May; 60 (5):1132-40 Epub 2014 Dec 12 View PubMed PST-20587949 Home Publications