Tamra I. Ranasinghe, M.B.B.S.

Tamra  I. Ranasinghe, M.B.B.S., is a vascular neurologist at Mayo Clinic in Phoenix, Arizona. He specializes in the diagnosis, treatment and prevention of stroke and other cerebrovascular disorders, with particular expertise in complex and recurrent ischemic stroke and determining the underlying cause of stroke.

Dr. Ranasinghe has a special interest in cardioembolic stroke and the relationship between cardiovascular and cerebrovascular disease. He serves as Co-Lead of the Heart and Brain Clinic at Mayo Clinic, where specialists in vascular neurology and cardiovascular medicine collaborate in the evaluation and management of patients with complex heart-brain conditions.

Areas of expertise

Dr. Ranasinghe focuses on individualized, evidence‑based care for people with stroke and cerebrovascular disease.

• Acute ischemic stroke and transient ischemic attack (TIA)
• Cardioembolic stroke, including atrial fibrillation related stroke
• Cryptogenic stroke
• Intracranial atherosclerotic disease
• Carotid artery atherosclerotic disease
• Cervical artery dissection
• PFO associated stroke
• Stroke and left atrial appendage closure
• Secondary stroke prevention
• Intracerebral hemorrhage
• Cerebral amyloid angiopathy
• Cerebral venous thrombosis
• Stroke in younger adults
• Other complex cerebrovascular disorders

Education and research

Dr. Ranasinghe completed his Neurology Residency and served as Chief Resident at West Virginia University before completing a Vascular Neurology Fellowship and NIH StrokeNet Fellowship at the University of California San Diego. He is board‑certified in Neurology and Vascular Neurology by the American Board of Psychiatry and Neurology and is a Fellow of the American Heart Association (FAHA).

He is an Assistant Professor of Neurology at Mayo Clinic College of Medicine and Science and serves as Program Director of the Vascular Neurology Fellowship at Mayo Clinic in Arizona. He is actively involved in medical student and neurology resident education and mentorship. His teaching has been recognized with the Mayo Clinic Department of Neurology Teacher of the Year Award for 2024 — 2025 and the American Academy of Neurology A.B. Baker Teacher Recognition Award in 2026.

His research interests include acute stroke treatment, secondary stroke prevention, cryptogenic and cardioembolic stroke, and heart-brain relationship. He has served as a site principal investigator and co-investigator for multiple multicenter stroke clinical trials, including NIH StrokeNet studies, with research spanning thrombolysis, intracranial atherosclerotic disease, atrial fibrillation and other cardiac sources of stroke, cervical artery dissection and intracerebral hemorrhage.