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Timothy J. Nelson, M.D., Ph.D.

  1. Internist
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Publications

  1. Birker K, Ge S, Kirkland NJ, Theis JL, Marchant J, Fogarty ZC, Missinato MA, Kalvakuri S, Grossfeld P, Engler AJ, Ocorr K, Nelson TJ, Colas AR, Olson TM, Vogler G, Bodmer R. Mitochondrial MICOS complex genes, implicated in hypoplastic left heart syndrome, maintain cardiac contractility and actomyosin integrity. Elife. 2023 Jul 5; 12 Epub 2023 July 05
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  2. Odogwu NM, Hagen C, Nelson TJ. Transcriptome studies of congenital heart diseases: identifying current gaps and therapeutic frontiers. Front Genet. 2023; 14:1278747 Epub 2023 Dec 13
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  3. Clemens DJ, Ye D, Zhou W, Kim CSJ, Pease DR, Navaratnarajah CK, Barkhymer A, Tester DJ, Nelson TJ, Cattaneo R, Schneider JW, Ackerman MJ. SARS-CoV-2 spike protein-mediated cardiomyocyte fusion may contribute to increased arrhythmic risk in COVID-19. PLoS One. 2023; 18(3):e0282151. Epub 2023 Mar 08.
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  4. Minter Dykhouse K, Minter-Dykhouse K, Nelson TJ, Folmes CDL. Uncoupling of Proliferative Capacity from Developmental Stage During Directed Cardiac Differentiation of Pluripotent Stem Cells. Stem Cells Dev. 2022 Sep; 31 (17-18):521-528 Epub 2022 July 25
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  5. Gates KV, Panicker AJ, Biendarra-Tiegs SM, Vetr NG, Lopera Higuita M, Nelson TJ, Pereira NL, Griffiths LG. Shotgun Immunoproteomics for Identification of Nonhuman Leukocyte Antigens Associated With Cellular Dysfunction in Heart Transplant Rejection. Transplantation. 2022 Jul 1; 106 (7):1376-1389 Epub 2021 Dec 17
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  6. Holst KA, Dearani JA, Qureshi MY, Wackel P, Cannon BC, O'Leary PW, Olson TM, Seisler DK, Nelson TJ, Wanek HLHS Consortium Clinical Pipeline. From Safety to Benefit in Cell Delivery During Surgical Repair of Ebstein Anomaly: Initial Results. Ann Thorac Surg. 2022 Mar; 113 (3):890-895 Epub 2021 Feb 01
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  7. Landry M, Katers M, Olson E, Cern L, Nelson TJ, Campbell KA. Identifying gaps in parental support for families of children with hypoplastic left heart syndrome. Cardiol Young. 2022 Feb; 32 (2):215-222 Epub 2021 May 10
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  8. Oommen S, Cantero Peral S, Qureshi MY, Holst KA, Burkhart HM, Hathcock MA, Kremers WK, Brandt EB, Larsen BT, Dearani JA, Edwards BS, Maleszewski JJ, Nelson TJ, Wanek Program Pre-Clinical Pipeline. Autologous Umbilical Cord Blood-Derived Mononuclear Cell Therapy Promotes Cardiac Proliferation and Adaptation in a Porcine Model of Right Ventricle Pressure Overload. Cell Transplant. 2022 Jan-Dec; 31:9636897221120434
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  9. O'Leary PW, Qureshi MY, Cetta F, Nelson TJ, Holst KA, Dearani JA, Wanek Program Clinical Pipeline Group. Cone Reconstruction for Ebstein Anomaly: Ventricular Remodeling and Preliminary Impact of Stem Cell Therapy. Mayo Clin Proc. 2021 Dec; 96 (12):3053-3061 Epub 2021 Sept 01
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  10. Heard KJ, Shokhirev MN, Becronis C, Fredlender C, Zahid N, Le AT, Ji Y, Skime M, Nelson T, Hall-Flavin D, Weinshilboum R, Gage FH, Vadodaria KC. Chronic cortisol differentially impacts stem cell-derived astrocytes from major depressive disorder patients. Transl Psychiatry. 2021 Nov 30; 11 (1):608
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  11. Schneider JW, Oommen S, Qureshi MY, Goetsch SC, Pease DR, Sundsbak RS, Guo W, Sun M, Sun H, Kuroyanagi H, Webster DA, Coutts AW, Holst KA, Edwards BS, Newville N, Hathcock MA, Melkamu T, Briganti F, Wei W, Romanelli MG, Fahrenkrug SC, Frantz DE, Olson TM, Steinmetz LM, Carlson DF, Nelson TJ, Wanek Program Preclinical Pipeline. Author Correction: Dysregulated ribonucleoprotein granules promote cardiomyopathy in RBM20 gene-edited pigs. Nat Med. 2021 Jul; 27 (7):1309
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  12. Brandt EB, Li X, Nelson TJ. Activation of P53 Via Nutlin-3a Reveals Role for P53 In ROS Signaling During Cardiac Differentiation of hiPSCs. J Stem Cell Rep. 2021; 3 (1) Epub 2021 Mar 27
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  13. Vincenti M, Qureshi MY, Niaz T, Seisler DK, Nelson TJ, Cetta F. Loss of Ventricular Function After Bidirectional Cavopulmonary Connection: Who Is at Risk? Pediatr Cardiol. 2020 Dec; 41 (8):1714-1724 Epub 2020 Aug 11
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  14. Vincenti M, O'Leary PW, Qureshi MY, Seisler DK, Burkhart HM, Cetta F, Nelson TJ, Wanek HLHS Consortium Clinical Pipeline. Clinical Impact of Autologous Cell Therapy on Hypoplastic Left Heart Syndrome After Bidirectional Cavopulmonary Anastomosis. Semin Thorac Cardiovasc Surg. 2020 Nov 7 Epub 2020 Nov 07
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  15. Schneider JW, Oommen S, Qureshi MY, Goetsch SC, Pease DR, Sundsbak RS, Guo W, Sun M, Sun H, Kuroyanagi H, Webster DA, Coutts AW, Holst KA, Edwards BS, Newville N, Hathcock MA, Melkamu T, Briganti F, Wei W, Romanelli MG, Fahrenkrug SC, Frantz DE, Olson TM, Steinmetz LM, Carlson DF, Nelson TJ, Wanek Program Preclinical Pipeline. Dysregulated ribonucleoprotein granules promote cardiomyopathy in RBM20 gene-edited pigs. Nat Med. 2020 Nov; 26 (11):1788-1800 Epub 2020 Nov 13
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  16. Theis JL, Vogler G, Missinato MA, Li X, Nielsen T, Zeng XI, Martinez-Fernandez A, Walls SM, Kervadec A, Kezos JN, Birker K, Evans JM, O'Byrne MM, Fogarty ZC, Terzic A, Grossfeld P, Ocorr K, Nelson TJ, Olson TM, Colas AR, Bodmer R. Patient-specific genomics and cross-species functional analysis implicate LRP2 in hypoplastic left heart syndrome. Elife. 2020 Oct 2; 9 Epub 2020 Oct 02
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  17. Miao Y, Tian L, Martin M, Paige SL, Galdos FX, Li J, Klein A, Zhang H, Ma N, Wei Y, Stewart M, Lee S, Moonen JR, Zhang B, Grossfeld P, Mital S, Chitayat D, Wu JC, Rabinovitch M, Nelson TJ, Nie S, Wu SM, Gu M. Intrinsic Endocardial Defects Contribute to Hypoplastic Left Heart Syndrome. Cell Stem Cell. 2020 Oct 1; 27 (4):574-589.e8 Epub 2020 Aug 17
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  18. Kargaran PK, Evans JM, Bodbin SE, Smith JGW, Nelson TJ, Denning C, Mosqueira D. Mitochondrial DNA: Hotspot for Potential Gene Modifiers Regulating Hypertrophic Cardiomyopathy. J Clin Med. 2020 Jul 23; 9(8).
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  19. Klein Gunnewiek TM, Van Hugte EJH, Frega M, Guardia GS, Foreman K, Panneman D, Mossink B, Linda K, Keller JM, Schubert D, Cassiman D, Rodenburg R, Vidal Folch N, Oglesbee D, Perales-Clemente E, Nelson TJ, Morava E, Nadif Kasri N, Kozicz T. m.3243A > G-Induced Mitochondrial Dysfunction Impairs Human Neuronal Development and Reduces Neuronal Network Activity and Synchronicity. Cell Rep. 2020 Apr 21; 31 (3):107538
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  20. Smith C, Martin-Lillie C, Higano JD, Turner L, Phu S, Arthurs J, Nelson TJ, Shapiro S, Master Z. Challenging misinformation and engaging patients: characterizing a regenerative medicine consult service. Regen Med. 2020 Mar; 15 (3):1427-1440 Epub 2020 Apr 22
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  21. Biendarra-Tiegs SM, Clemens DJ, Secreto FJ, Nelson TJ. Human Induced Pluripotent Stem Cell-Derived Non-Cardiomyocytes Modulate Cardiac Electrophysiological Maturation Through Connexin 43-Mediated Cell-Cell Interactions. Stem Cells Dev. 2020 Jan 15; 29 (2):75-89 Epub 2019 Dec 16
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  22. Biendarra-Tiegs SM, Secreto FJ, Nelson TJ. Addressing Variability and Heterogeneity of Induced Pluripotent Stem Cell-Derived Cardiomyocytes. Adv Exp Med Biol. 2020; 1212:1-29
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  23. Burkhart HM, Qureshi MY, Rossano JW, Cantero Peral S, O'Leary PW, Hathcock M, Kremers W, Nelson TJ, Wanek HLHS Consortium Clinical Pipeline. Autologous stem cell therapy for hypoplastic left heart syndrome: Safety and feasibility of intraoperative intramyocardial injections. J Thorac Cardiovasc Surg. 2019 Dec; 158(6):1614-1623. Epub 2019 Jun 07.
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  24. Schroeder AM, Allahyari M, Vogler G, Missinato MA, Nielsen T, Yu MS, Theis JL, Larsen LA, Goyal P, Rosenfeld JA, Nelson TJ, Olson TM, Colas AR, Grossfeld P, Bodmer R. Model system identification of novel congenital heart disease gene candidates: focus on RPL13. Hum Mol Genet. 2019 Dec 1; 28 (23):3954-3969
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  25. Saraf A, Book WM, Nelson TJ, Xu C. Hypoplastic left heart syndrome: From bedside to bench and back. J Mol Cell Cardiol. 2019 Oct; 135:109-118 Epub 2019 Aug 13
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  26. Vadodaria KC, Ji Y, Skime M, Paquola A, Nelson T, Hall-Flavin D, Fredlender C, Heard KJ, Deng Y, Le AT, Dave S, Fung L, Li X, Marchetto MC, Weinshilboum R, Gage FH. Serotonin-induced hyperactivity in SSRI-resistant major depressive disorder patient-derived neurons. Mol Psychiatry. 2019 Jun; 24 (6):795-807 Epub 2019 Jan 30
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  27. Vadodaria KC, Ji Y, Skime M, Paquola AC, Nelson T, Hall-Flavin D, Heard KJ, Fredlender C, Deng Y, Elkins J, Dani K, Le AT, Marchetto MC, Weinshilboum R, Gage FH. Altered serotonergic circuitry in SSRI-resistant major depressive disorder patient-derived neurons. Mol Psychiatry. 2019 Jun; 24 (6):808-818 Epub 2019 Mar 22
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  28. Biendarra-Tiegs SM, Li X, Ye D, Brandt EB, Ackerman MJ, Nelson TJ. Single-Cell RNA-Sequencing and Optical Electrophysiology of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes Reveal Discordance Between Cardiac Subtype-Associated Gene Expression Patterns and Electrophysiological Phenotypes. Stem Cells Dev. 2019 May 15; 28 (10):659-673 Epub 2019 Apr 17
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  29. Johnson AA, Andrews-Pfannkoch C, Nelson TJ, Pulido JS, Marmorstein AD. Disease modeling studies using induced pluripotent stem cells: are we using enough controls? Regen Med. 2017 Dec 15 [Epub ahead of print]
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  30. Secreto FJ, Li X, Smith AJ, Bruinsma ES, Perales-Clemente E, Oommen S, Hawse G, Hrstka SCL, Arendt BK, Brandt EB, Wigle DA, Nelson TJ. Quantification of Etoposide Hypersensitivity: A Sensitive, Functional Method for Assessing Pluripotent Stem Cell Quality. Stem Cells Transl Med. 2017 Oct; 6(10):1829-1839. Epub 2017 Sep 19.
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  31. Hrstka SC, Li X, Nelson TJ, Wanek Program Genetics Pipeline Group. NOTCH1-Dependent Nitric Oxide Signaling Deficiency in Hypoplastic Left Heart Syndrome Revealed Through Patient-Specific Phenotypes Detected in Bioengineered Cardiogenesis. Stem Cells. 2017 Apr; 35 (4):1106-1119 Epub 2017 Mar 05
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  32. Holst KA, Said SM, Nelson TJ, Cannon BC, Dearani JA. Current Interventional and Surgical Management of Congenital Heart Disease: Specific Focus on Valvular Disease and Cardiac Arrhythmias. Circ Res. 2017 Mar 17; 120: (6)1027-1044.
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  33. Cantero Peral S, Bernstein D, Nelson TJ. Regenerative medicine - from stem cell biology to clinical trials for pediatric heart failure Progress In Pediatric Cardiology. 2016 Dec; 43:87-9.
  34. Aho JM, Dietz AB, Radel DJ, Butler GW, Thomas M, Nelson TJ, Carlsen BT, Cassivi SD, Resch ZT, Faubion WA, Wigle DA. Closure of a Recurrent Bronchopleural Fistula Using a Matrix Seeded With Patient-Derived Mesenchymal Stem Cells. Stem Cells Transl Med. 2016 Oct; 5 (10):1375-1379 Epub 2016 June 24
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  35. Kirkpatrick DR, McEntire DM, Smith TA, Dueck NP, Kerfeld MJ, Hambsch ZJ, Nelson TJ, Reisbig MD, Agrawal DK. Transmission pathways and mediators as the basis for clinical pharmacology of pain. Expert Rev Clin Pharmacol. 2016 Oct; 9 (10):1363-1387 Epub 2016 July 04
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  36. Perales-Clemente E, Cook AN, Evans JM, Roellinger S, Secreto F, Emmanuele V, Oglesbee D, Mootha VK, Hirano M, Schon EA, Terzic A, Nelson TJ. Natural underlying mtDNA heteroplasmy as a potential source of intra-person hiPSC variability. EMBO J. 2016 Sep 15; 35 (18):1979-90 Epub 2016 July 19
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  37. McEntire DM, Kirkpatrick DR, Dueck NP, Kerfeld MJ, Smith TA, Nelson TJ, Reisbig MD, Agrawal DK. Pain transduction: a pharmacologic perspective. Expert Rev Clin Pharmacol. 2016 Aug; 9 (8):1069-80 Epub 2016 May 23
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  38. Nelson TJ, Cantero Peral S. Stem Cell Therapy and Congenital Heart Disease. J Cardiovasc Dev Dis. 2016 Jul 5; 3 (3) Epub 2016 July 05
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  39. Wyles SP, Hrstka SC, Reyes S, Terzic A, Olson TM, Nelson TJ. Pharmacological Modulation of Calcium Homeostasis in Familial Dilated Cardiomyopathy: An In Vitro Analysis From an RBM20 Patient-Derived iPSC Model. Clin Transl Sci. 2016 Jun; 9 (3):158-67 Epub 2016 Apr 22
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  40. Li X, Campbell KA, Biendarra SM, Terzic A, Nelson TJ. Mapping transcriptome profiles of in vitro iPSC-derived cardiac differentiation to in utero heart development. Genom Data. 2016 Mar; 7:129-30 Epub 2015 Dec 30
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  41. Wyles SP, Li X, Hrstka SC, Reyes S, Oommen S, Beraldi R, Edwards J, Terzic A, Olson TM, Nelson TJ. Modeling structural and functional deficiencies of RBM20 familial dilated cardiomyopathy using human induced pluripotent stem cells. Hum Mol Genet. 2016 Jan 15; 25 (2):254-65 Epub 2015 Nov 24
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  42. Campbell KA, Li X, Biendarra SM, Terzic A, Nelson TJ. Nos3-/- iPSCs model concordant signatures of in utero cardiac pathogenesis. J Mol Cell Cardiol. 2015 Oct; 87:228-36.
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  43. Dearani JA, Mora BN, Nelson TJ, Haile DT, O'Leary PW. Ebstein anomaly review: what's now, what's next? Expert Rev Cardiovasc Ther. 2015 Oct; 13 (10):1101-9 Epub 2015 Sept 10
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  44. Theis JL, Hrstka SC, Evans JM, O'Byrne MM, de Andrade M, O'Leary PW, Nelson TJ, Olson TM. Compound heterozygous NOTCH1 mutations underlie impaired cardiogenesis in a patient with hypoplastic left heart syndrome. Hum Genet. 2015 Sep; 134 (9):1003-11 Epub 2015 July 12
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  45. Wyles SP, Faustino RS, Li X, Terzic A, Nelson TJ. Systems-based technologies in profiling the stem cell molecular framework for cardioregenerative medicine. Stem Cell Rev. 2015 Jun; 11: (3)501-10.
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  46. Yamada S, Arrell DK, Martinez-Fernandez A, Behfar A, Kane GC, Perez-Terzic CM, Crespo-Diaz RJ, McDonald RJ, Wyles SP, Zlatkovic-Lindor J, Nelson TJ, Terzic A. Regenerative Therapy Prevents Heart Failure Progression in Dyssynchronous Nonischemic Narrow QRS Cardiomyopathy. J Am Heart Assoc. 2015 May 11; 4 (5)
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  47. Oommen S, Yamada S, Cantero Peral S, Campbell KA, Bruinsma ES, Terzic A, Nelson TJ. Human umbilical cord blood-derived mononuclear cells improve murine ventricular function upon intramyocardial delivery in right ventricular chronic pressure overload. Stem Cell Res Ther. 2015 Mar 26; 6:50
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  48. Burkhart HM, Qureshi MY, Peral SC, O'Leary PW, Olson TM, Cetta F, Nelson TJ, Wanek Program Clinical Pipeline Group. Regenerative therapy for hypoplastic left heart syndrome: first report of intraoperative intramyocardial injection of autologous umbilical-cord blood-derived cells. J Thorac Cardiovasc Surg. 2015 Mar; 149: (3)e35-7.
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  49. Cantero Peral S, Burkhart HM, Oommen S, Yamada S, Nyberg SL, Li X, O'Leary PW, Terzic A, Cannon BC, Nelson TJ, Wanek Program Porcine Pipeline Group. Safety and feasibility for pediatric cardiac regeneration using epicardial delivery of autologous umbilical cord blood-derived mononuclear cells established in a porcine model system. Stem Cells Transl Med. 2015 Feb; 4(2):195-206. Epub 2015 Jan 05.
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  50. Campbell KA, Terzic A, Nelson TJ. Induced pluripotent stem cells for cardiovascular disease: from product-focused disease modeling to process-focused disease discovery. Regen Med. 2015; 10 (6):773-83 Epub 2015 Oct 06
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  51. Wyles SP, Brandt EB, Nelson TJ. Stem cells: the pursuit of genomic stability. Int J Mol Sci. 2014 Nov 14; 15 (11):20948-67
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  52. Peral SC, Burkhart HM, Nelson TJ. Utilization of stem cells to treat congenital heart disease: hype and hope. Curr Opin Pediatr. 2014 Oct; 26(5):553-60.
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  53. Wyles SP, Yamada S, Oommen S, Maleszewski JJ, Beraldi R, Martinez-Fernandez A, Terzic A, Nelson TJ. Inhibition of DNA topoisomerase II selectively reduces the threat of tumorigenicity following induced pluripotent stem cell-based myocardial therapy. Stem Cells Dev. 2014 Oct 1; 23 (19):2274-82 Epub 2014 Aug 21
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  54. Martinez-Fernandez A, Nelson TJ, Reyes S, Alekseev AE, Secreto F, Perez-Terzic C, Beraldi R, Sung HK, Nagy A, Terzic A. iPS cell-derived cardiogenicity is hindered by sustained integration of reprogramming transgenes. Circ Cardiovasc Genet. 2014 Oct; 7 (5):667-76 Epub 2014 July 30
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  55. Hartjes KA, Li X, Martinez-Fernandez A, Roemmich AJ, Larsen BT, Terzic A, Nelson TJ. Selection via pluripotency-related transcriptional screen minimizes the influence of somatic origin on iPSC differentiation propensity. Stem Cells. 2014 Sep; 32 (9):2350-9
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  56. Suresh R, Li X, Chiriac A, Goel K, Terzic A, Perez-Terzic C, Nelson TJ. Transcriptome from circulating cells suggests dysregulated pathways associated with long-term recurrent events following first-time myocardial infarction. J Mol Cell Cardiol. 2014 Sep; 74:13-21 Epub 2014 May 04
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  57. Beraldi R, Li X, Martinez Fernandez A, Reyes S, Secreto F, Terzic A, Olson TM, Nelson TJ. Rbm20-deficient cardiogenesis reveals early disruption of RNA processing and sarcomere remodeling establishing a developmental etiology for dilated cardiomyopathy. Hum Mol Genet. 2014 Jul 15; 23 (14):3779-91 Epub 2014 Feb 28
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  58. Li X, Martinez-Fernandez A, Hartjes KA, Kocher JP, Olson TM, Terzic A, Nelson TJ. Transcriptional atlas of cardiogenesis maps congenital heart disease interactome. Physiol Genomics. 2014 Jul 1; 46 (13):482-95 Epub 2014 May 06
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  59. Yang J, Hartjes KA, Nelson TJ, Xu X. Cessation of contraction induces cardiomyocyte remodeling during zebrafish cardiogenesis. Am J Physiol Heart Circ Physiol. 2014 Feb; 306 (3):H382-95 Epub 2013 Dec 06
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  60. Chamberland C, Martinez-Fernandez A, Beraldi R, Nelson TJ. Embroynic decellularized cardiac scaffold supports embryonic stem cell differentiation to produce beating cardiac tissue. ISRN Stem Cells. 2014; 2014(Article ID 625164):10 pages.
  61. Bazil JN, Stamm KD, Li X, Thiagarajan R, Nelson TJ, Tomita-Mitchell A, Beard DA. The inferred cardiogenic gene regulatory network in the mammalian heart. PLoS One. 2014; 9 (6):e100842 Epub 2014 June 27
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  62. Yamada S, Arrell DK, Kane GC, Nelson TJ, Perez-Terzic CM, Behfar A, Purushothaman S, Prinzen FW, Auricchio A, Terzic A. Mechanical dyssynchrony precedes QRS widening in ATP-sensitive K(+) channel-deficient dilated cardiomyopathy. J Am Heart Assoc. 2013 Dec 5; 2 (6):e000410 Epub 2013 Dec 05
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  63. Martinez-Fernandez A, Li X, Hartjes KA, Terzic A, Nelson TJ. Natural cardiogenesis-based template predicts cardiogenic potential of induced pluripotent stem cell lines. Circ Cardiovasc Genet. 2013 Oct; 6 (5):462-71 Epub 2013 Sept 14
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  64. Suresh R, Chiriac A, Goel K, Villarraga HR, Lopez-Jimenez F, Thomas RJ, Terzic A, Nelson TJ, Perez-Terzic C. CXCR4+ and FLK-1+ identify circulating cells associated with improved cardiac function in patients following myocardial infarction. J Cardiovasc Transl Res. 2013 Oct; 6 (5):787-97 Epub 2013 Aug 10
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  65. Hasin T, Gerber Y, McNallan SM, Weston SA, Kushwaha SS, Nelson TJ, Cerhan JR, Roger VL. Patients with heart failure have an increased risk of incident cancer. J Am Coll Cardiol. 2013 Sep 3; 62 (10):881-6 Epub 2013 June 27
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  66. Yamada S, Nelson TJ, Kane GC, Martinez-Fernandez A, Crespo-Diaz RJ, Ikeda Y, Perez-Terzic C, Terzic A. Induced pluripotent stem cell intervention rescues ventricular wall motion disparity, achieving biological cardiac resynchronization post-infarction. J Physiol. 2013 Sep 1; 591 (17):4335-49 Epub 2013 Apr 08
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  67. Campbell JM, Hartjes KA, Nelson TJ, Xu X, Ekker SC. New and TALENted genome engineering toolbox. Circ Res. 2013 Aug 16; 113 (5):571-87
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  68. Folmes CD, Arrell DK, Zlatkovic-Lindor J, Martinez-Fernandez A, Perez-Terzic C, Nelson TJ, Terzic A. Metabolome and metaboproteome remodeling in nuclear reprogramming. Cell Cycle. 2013 Aug 1; 12 (15):2355-65 Epub 2013 July 08
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  69. Folmes CD, Martinez-Fernandez A, Perales-Clemente E, Li X, McDonald A, Oglesbee D, Hrstka SC, Perez-Terzic C, Terzic A, Nelson TJ. Disease-causing mitochondrial heteroplasmy segregated within induced pluripotent stem cell clones derived from a patient with MELAS. Stem Cells. 2013 Jul; 31 (7):1298-308
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  70. Terzic A, Nelson TJ. Regenerative medicine primer. Mayo Clin Proc. 2013 Jul; 88 (7):766-75
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  71. Folmes CD, Martinez-Fernandez A, Faustino RS, Yamada S, Perez-Terzic C, Nelson TJ, Terzic A. Nuclear reprogramming with c-Myc potentiates glycolytic capacity of derived induced pluripotent stem cells. J Cardiovasc Transl Res. 2013 Feb; 6 (1):10-21 Epub 2012 Dec 18
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  72. Folmes CD, Dzeja PP, Nelson TJ, Terzic A. Metabolic plasticity in stem cell homeostasis and differentiation. Cell Stem Cell. 2012 Nov 2; 11 (5):596-606
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  73. Zacharias DG, Nelson TJ, Mueller PS, Hook CC. Impedance of novel therapeutic technologies: the case of stem cells. Clin Transl Sci. 2012 Oct; 5(5):422-7. Epub 2012 Jun 28.
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  74. Smith AJ, Nelson NG, Oommen S, Hartjes KA, Folmes CD, Terzic A, Nelson TJ. Apoptotic susceptibility to DNA damage of pluripotent stem cells facilitates pharmacologic purging of teratoma risk. Stem Cells Transl Med. 2012 Oct; 1 (10):709-18 Epub 2012 Sept 27
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  75. Folmes CDL, Nelson TJ, Dzeja PP, Terzic A. Energy metabolism plasticity enables stemness programs. Ann N Y Acad Sci. 2012 Apr; 1254:82-89
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  76. Folmes CD, Nelson TJ, Terzic A. Energy metabolism in nuclear reprogramming. Biomark Med. 2011 Dec; 5: (6)715-29.
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  77. Folmes CD, Nelson TJ, Martinez-Fernandez A, Arrell DK, Lindor JZ, Dzeja PP, Ikeda Y, Perez-Terzic C, Terzic A. Somatic oxidative bioenergetics transitions into pluripotency-dependent glycolysis to facilitate nuclear reprogramming. Cell Metab. 2011 Aug 3; 14 (2):264-71
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  78. Zacharias DG, Nelson TJ, Mueller PS, Hook CC. The science and ethics of induced pluripotency: what will become of embryonic stem cells? Mayo Clin Proc. 2011 Jul; 86 (7):634-40
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  79. Terzic A, Edwards BS, McKee KC, Nelson TJ. Regenerative medicine: a reality of stem cell technology. Minn Med. 2011 May; 94(5):44-7.
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  80. Nelson TJ, Terzic A. Induced pluripotent stem cells: an emerging theranostics platform. Clin Pharmacol Ther. 2011 May; 89(5):648-50.
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  81. Martinez-Fernandez A, Nelson TJ, Terzic A. Nuclear reprogramming strategy modulates differentiation potential of induced pluripotent stem cells. J Cardiovasc Transl Res. 2011 Apr; 4 (2):131-7 Epub 2011 Jan 05
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  82. Thatava T, Nelson TJ, Edukulla R, Sakuma T, Ohmine S, Tonne JM, Yamada S, Kudva Y, Terzic A, Ikeda Y. Indolactam V/GLP-1-mediated differentiation of human iPS cells into glucose-responsive insulin-secreting progeny. Gene Ther. 2011 Mar; 18 (3):283-93 Epub 2010 Nov 04
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  83. Chiriac A, Terzic A, Park S, Ikeda Y, Faustino R, Nelson TJ. SDF-1-enhanced cardiogenesis requires CXCR4 induction in pluripotent stem cells. J Cardiovasc Transl Res. 2010 Dec; 3 (6):674-82 Epub 2010 Sept 15
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  84. Nelson TJ, Martinez-Fernandez A, Terzic A. Induced pluripotent stem cells: developmental biology to regenerative medicine. Nat Rev Cardiol. 2010 Dec; 7 (12):700-10 Epub 2010 Oct 19
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  85. Behfar A, Crespo-Diaz R, Nelson TJ, Terzic A, Gersh BJ. Stem cells: clinical trials results the end of the beginning or the beginning of the end? Cardiovasc Hematol Disord Drug Targets. 2010 Sep 1; 10 (3):186-201
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  86. Zlatkovic-Lindor J, Arrell DK, Yamada S, Nelson TJ, Terzic A. ATP-sensitive K(+) channel-deficient dilated cardiomyopathy proteome remodeled by embryonic stem cell therapy. Stem Cells. 2010 Aug; 28 (8):1355-67
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  87. Faustino RS, Chiriac A, Niederlander NJ, Nelson TJ, Behfar A, Mishra PK, Macura S, Michalak M, Terzic A, Perez-Terzic C. Decoded calreticulin-deficient embryonic stem cell transcriptome resolves latent cardiophenotype. Stem Cells. 2010 Jul; 28 (7):1281-91
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  88. Chiriac A, Nelson TJ, Faustino RS, Behfar A, Terzic A. Cardiogenic induction of pluripotent stem cells streamlined through a conserved SDF-1/VEGF/BMP2 integrated network. PLoS One. 2010 Apr 1; 5 (4):e9943 Epub 2010 Apr 01
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  89. Martinez-Fernandez A, Nelson TJ, Ikeda Y, Terzic A. c-MYC independent nuclear reprogramming favors cardiogenic potential of induced pluripotent stem cells. J Cardiovasc Transl Res. 2010 Feb; 3 (1):13-23
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  90. Nelson TJ, Martinez-Fernandez A, Yamada S, Ikeda Y, Perez-Terzic C, Terzic A. Induced pluripotent stem cells: advances to applications. Stem Cells Cloning. 2010 Jan 1; 3:29-37
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  91. Waldman SA, Kraft WK, Nelson TJ, Terzic A. Clinical pharmacology: a paradigm for individualized medicine. Biomark. Med. 2009 Dec; 3(6):679-84.
  92. Waldman SA, Kraft WK, Nelson TJ, Terzic A. Experimental therapeutics: a paradigm for personalized medicine. Clin Transl Sci. 2009 Dec; 2(6):436-8.
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  93. Martinez-Fernandez A, Nelson TJ, Yamada S, Reyes S, Alekseev AE, Perez-Terzic C, Ikeda Y, Terzic A. iPS programmed without c-MYC yield proficient cardiogenesis for functional heart chimerism. Circ Res. 2009 Sep 25; 105 (7):648-56 Epub 2009 Aug 20
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  94. Nelson TJ, Martinez-Fernandez A, Yamada S, Perez-Terzic C, Ikeda Y, Terzic A. Repair of acute myocardial infarction by human stemness factors induced pluripotent stem cells. Circulation. 2009 Aug 4; 120 (5):408-16 Epub 2009 July 20
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  95. Yamada S, Nelson TJ, Behfar A, Crespo-Diaz RJ, Fraidenraich D, Terzic A. Stem cell transplant into preimplantation embryo yields myocardial infarction-resistant adult phenotype. Stem Cells. 2009 Jul; 27 (7):1697-705
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  96. Nelson TJ, Behfar A, Yamada S, Martinez-Fernandez A, Terzic A. Stem cell platforms for regenerative medicine. Clin Transl Sci. 2009 Jun; 2 (3):222-7
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  99. Nelson TJ, Martinez-Fernandez A, Terzic A. KCNJ11 knockout morula re-engineered by stem cell diploid aggregation. Philos Trans R Soc Lond B Biol Sci. 2009 Jan 27; 364 (1514):269-76
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  100. Nelson T, Behfar A, Terzic A. Stem cells: biologics for regeneration. Clin Pharmacol Ther. 2008 Nov; 84(5):620-3. Epub 2008 Aug 13.
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  101. Yamada S, Nelson TJ, Crespo-Diaz RJ, Perez-Terzic C, Liu XK, Miki T, Seino S, Behfar A, Terzic A. Embryonic stem cell therapy of heart failure in genetic cardiomyopathy. Stem Cells. 2008 Oct; 26(10):2644-53. Epub 2008 Jul 31.
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  102. Nelson TJ, Behfar A, Terzic A. Strategies for therapeutic repair: The "R(3)" regenerative medicine paradigm. Clin Transl Sci. 2008 Sep; 1 (2):168-171
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  103. Nelson TJ, Faustino RS, Chiriac A, Crespo-Diaz R, Behfar A, Terzic A. CXCR4+/FLK-1+ biomarkers select a cardiopoietic lineage from embryonic stem cells. Stem Cells. 2008 Jun; 26(6):1464-73. Epub 2008 Mar 27.
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  104. Faustino RS, Nelson TJ, Terzic A, Perez-Terzic C. Nuclear transport: target for therapy. Clin Pharmacol Ther. 2007 Jun; 81(6):880-6. Epub 2007 Apr 18.
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  105. Chaka G, Sonnenberg JL, Schlegel HB, Heeg MJ, Jaeger G, Nelson TJ, Ochrymowycz LA, Rorabacher DB. A definitive example of a geometric "entatic state" effect: electron-transfer kinetics for a copper(II/I) complex involving A quinquedentate macrocyclic trithiaether-bipyridine ligand. J Am Chem Soc. 2007 Apr 25; 129(16):5217-27. Epub 2007 Mar 29.
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  106. Nelson TJ, Ge ZD, Van Orman J, Barron M, Rudy-Reil D, Hacker TA, Misra R, Duncan SA, Auchampach JA, Lough JW. Improved cardiac function in infarcted mice after treatment with pluripotent embryonic stem cells. Anat Rec A Discov Mol Cell Evol Biol. 2006 Nov; 288(11):1216-24.
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  107. Nelson TJ, Balza R Jr, Xiao Q, Misra RP. SRF-dependent gene expression in isolated cardiomyocytes: regulation of genes involved in cardiac hypertrophy. J Mol Cell Cardiol. 2005 Sep; 39(3):479-89.
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  108. Nelson TJ, Duncan SA, Misra RP. Conserved enhancer in the serum response factor promoter controls expression during early coronary vasculogenesis. Circ Res. 2004 Apr 30; 94(8):1059-66. Epub 2004 Mar 04.
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  109. Peterson FC, Elgin ES, Nelson TJ, Zhang F, Hoeger TJ, Linhardt RJ, Volkman BF. Identification and characterization of a glycosaminoglycan recognition element of the C chemokine lymphotactin. J Biol Chem. 2004 Mar 26; 279(13):12598-604. Epub 2004 Jan 5
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  110. Kandegedara A, Krylova K, Nelson TJ, Schroeder RR, Ochrymowycz, LA, Rorabacher DB. Electron-transfer kinetics and equilibria of copper (II/I) complexes with 1,4,7-trithiacyclononane. A square scheme mechanism in ligand addition. J Chem Soc, Dalton Trans. 2002:792-801.
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