Avni Y. Joshi, M.D., M.S.

Avni Yogesh Joshi, M.D., M.S., is Chair of the Division of Pediatric Allergy and Immunology at Mayo Clinic in Rochester, Minnesota. She is a consultant in the Division of Pediatric Allergy and Immunology, with joint appointments in the Divisions of Pulmonary, Critical Care, Allergy and Sleep Medicine and in Clinical Biochemistry and Immunology. Dr. Joshi provides care for children and adults with immune and allergic disorders in Rochester, Minnesota, and surrounding areas. Her multidisciplinary approach integrates compassionate patient care, advanced diagnostics and individualized treatment for people with complex immune and allergic conditions.

Dr. Joshi is board-certified in Pediatrics, Pediatric Infectious Diseases, and Allergy and Immunology. She also serves as Assistant Medical Director of the Cellular and Molecular Immunology Laboratory, co-leading test development and translational research focused on immune competence and primary immunodeficiency. As a professor of Pediatrics and Medicine at Mayo Clinic College of Medicine and Science, she mentors residents, fellows and medical students in clinical immunology and allergy, fostering the next generation of physician-scientists.

Areas of expertise

Dr. Joshi provides comprehensive care for children, adolescents and adults with allergic, immunologic and respiratory conditions, offering advanced diagnostic and therapeutic options to restore immune balance and improve quality of life.

• Inborn errors of immunity: Evaluation, diagnosis and management of primary and secondary immunodeficiency disorders, including coordination of bone marrow transplantation for severe immune deficiencies.
• Food allergies: Clinical assessment, oral immunotherapy implementation (including FDA-approved treatments such as Palforzia), and strategies to minimize allergic reactions and improve tolerance.
• Asthma: Comprehensive testing and management of pediatric and adult asthma with a focus on environmental and immunologic triggers.
• Atopic diseases: Care for individuals with eczema, allergic rhinitis and related allergic conditions through preventive and personalized treatment strategies.

Research and expertise

Dr. Joshi's clinical and translational research explores immune deficiency, immune competence and the prevention of allergic diseases. She leads multiple national and international studies as a principal investigator, including work through the Primary Immune Deficiency Treatment Consortium (PIDTC) and the U.S. Immunodeficiency Network (USIDNET). Her investigations have advanced understanding of conditions such as severe combined immune deficiency (SCID), chronic granulomatous disease (CGD) and Wiskott-Aldrich syndrome (WAS), as well as environmental influences such as tobacco exposure and microbiome diversity on allergic disease.

She has received numerous honors, including the Pediatric Investigator of the Year award at Mayo Clinic and repeated recognition as a Top Doctor by Minnesota Monthly.

Dr. Joshi's leadership in clinical excellence, education and innovation embodies Mayo Clinic's commitment to patient-centered care and discovery in the field of allergy and immunology.