Patient Stories Print Specialized testing helps reverse effects of stiff-person syndromeJames and his wife Stephanie In July of 2018, James Kypuros woke up to find his toes clenched and claw-like, as if fisted. “It was a little bit weird walking this way, because you didn't have that balance of your toes extended,” recalls the 76-year-old Cedar Lake, Indiana resident. That summer marked the beginning of a host of debilitating symptoms that would defy significant treatment response until James came to Mayo Clinic, where specialized testing… Seeking, and finding, answers, comfort, and hopeAs someone affected by a rare, incurable disease, Joe Mondloch and his wife Sue are always on the lookout for new information. The autoimmune neurological condition Joe lives with has left him blind in one eye, physically disabled, and poses an ongoing threat for further damage. Called MOGAD, which stands for myelin oligodendrocyte glycoprotein associated-antibody disease, the rare, immune-mediated illness has been present in Joe’s life since February 2016, when, at the age of 55,… PST-20216465 Home Patient Stories