Heather M. Clark, Ph.D.

  1. Neurologic Communicative Disorder Specialist
  2. Speech-Language Pathologist

Publications

  1. Utianski RL, Martin PR, Duffy JR, Botha H, Clark HM, Josephs KA. Assessing Change in Communication Limitations in Primary Progressive Apraxia of Speech and Aphasia: A 1-Year Follow-Up Study. Am J Speech Lang Pathol. 2021 Sep 7; 1-11 Epub 2021 Sept 07
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  2. Whitwell JL, Tosakulwong N, Clark HM, Ali F, Botha H, Weigand SD, Sintini I, Machulda MM, Schwarz CG, Reid RI, Jack CR Jr, Ahlskog JE, Josephs KA. Diffusion tensor imaging analysis in three progressive supranuclear palsy variants. J Neurol. 2021 Sep; 268 (9):3409-3420 Epub 2021 Mar 12
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  3. Clark HM, Tosakulwong N, Weigand SD, Ali F, Botha H, Pham NTT, Schwarz CG, Reid RI, Senjem ML, Jack CR Jr, Lowe VJ, Ahlskog JE, Josephs KA, Whitwell JL. Gray and White Matter Correlates of Dysphagia in Progressive Supranuclear Palsy. Mov Disord. 2021 Aug 23 [Epub ahead of print]
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  4. Hokelekli FO, Ali F, Carlos AF, Martin PR, Clark HM, Duffy JR, Utianski RL, Botha H, St Louis EK, Whitwell JL, Josephs KA. Sleep disturbances in the speech-language variant of progressive supranuclear palsy. Parkinsonism Relat Disord. 2021 Aug 18; 91:9-12 [Epub ahead of print]
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  5. Polsinelli AJ, Machulda MM, Martin PR, Duffy JR, Clark HM, Butts AM, Botha H, Lowe VJ, Whitwell JL, Josephs KA, Utianski RL. Neuropsychological Profiles of Patients with Progressive Apraxia of Speech and Aphasia. J Int Neuropsychol Soc. 2021 Jul 22; 1-11 Epub 2021 July 22
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  6. Clark HM, Utianski RL, Ali F, Botha H, Whitwell JL, Josephs KA. Motor Speech Disorders and Communication Limitations in Progressive Supranuclear Palsy. Am J Speech Lang Pathol. 2021 Jun 18; 30 (3S):1361-1372 Epub 2021 Mar 09
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  7. Josephs KA, Duffy JR, Clark HM, Utianski RL, Strand EA, Machulda MM, Botha H, Martin PR, Pham NTT, Stierwalt J, Ali F, Buciuc M, Baker M, Fernandez De Castro CH, Spychalla AJ, Schwarz CG, Reid RI, Senjem ML, Jack CR Jr, Lowe VJ, Bigio EH, Reichard RR, Polley EJ, Ertekin-Taner N, Rademakers R, DeTure MA, Ross OA, Dickson DW, Whitwell JL. A molecular pathology, neurobiology, biochemical, genetic and neuroimaging study of progressive apraxia of speech. Nat Commun. 2021 Jun 8; 12 (1):3452 Epub 2021 June 08
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  8. Clark HM. Distinguishing Spastic and Dystonic Features in a Patient With a History of Brain Stem Encephalitis: A Clinical Case Study Perspectives of the ASHA Special Interest Groups. 2021.
  9. Whitwell JL, Martin P, Duffy JR, Clark HM, Utianski RL, Botha H, Machulda MM, Strand EA, Josephs KA. Survival Analysis in Primary Progressive Apraxia of Speech and Agrammatic Aphasia. Neurol Clin Pract. 2021 Jun; 11 (3):249-255
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  10. Dang J, Graff-Radford J, Duffy JR, Utianski RL, Clark HM, Stierwalt JA, Whitwell JL, Josephs KA, Botha H. Progressive apraxia of speech: delays to diagnosis and rates of alternative diagnoses. J Neurol. 2021 May 4 Epub 2021 May 04
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  11. Utianski RL, Martin PR, Hanley H, Duffy JR, Botha H, Clark HM, Whitwell JL, Josephs KA. A Longitudinal Evaluation of Speech Rate in Primary Progressive Apraxia of Speech. J Speech Lang Hear Res. 2021 Feb 17; 64 (2):392-404 Epub 2021 Jan 21
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  12. Chandregowda A, Stierwalt JA, Clark HM. Facilitating End-of-Life Interaction Between Patients With Severe Communication Impairment and Their Families Perspectives of the ASHA Special Interest Groups. 2021; 6(3):649-653.
  13. Curet Burleson AX, Pham NTT, Buciuc M, Botha H, Duffy JR, Clark HM, Utianski RL, Machulda MM, Baker MC, Rademakers R, Lowe VJ, Whitwell JL, Josephs KA. Neurobehavioral Characteristics of FDG-PET Defined Right-Dominant Semantic Dementia: A Longitudinal Study. Dement Geriatr Cogn Disord. 2021; 50 (1):17-28 Epub 2021 Mar 23
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  14. Seckin ZI, Duffy JR, Strand EA, Clark HM, Utianski RL, Machulda MM, Botha H, Ali F, Thu Pham NT, Lowe VJ, Whitwell JL, Josephs KA. The evolution of parkinsonism in primary progressive apraxia of speech: A 6-year longitudinal study. Parkinsonism Relat Disord. 2020 Dec; 81:34-40 Epub 2020 Oct 07
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  15. Utianski RL, Clark HM, Duffy JR, Botha H, Whitwell JL, Josephs KA. Communication Limitations in Patients With Progressive Apraxia of Speech and Aphasia. Am J Speech Lang Pathol. 2020 Nov 12; 29 (4):1976-1986 Epub 2020 Aug 05
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  16. Solomon Nancy, Clark Heather. The effect of an anti-slip surface on objective measures of tongue strength in healthy adults International Journal of Orofacial Myology and Myofunctional Therapy. 2020; 46(1):13-21.
  17. Ghirelli A, Tosakulwong N, Weigand SD, Clark HM, Ali F, Botha H, Duffy JR, Utianski RL, Buciuc M, Murray ME, Labuzan SA, Spychalla AJ, Pham NTT, Schwarz CG, Senjem ML, Machulda MM, Baker M, Rademakers R, Filippi M, Jack CR Jr, Lowe VJ, Parisi JE, Dickson DW, Josephs KA, Whitwell JL. Sensitivity-Specificity of Tau and Amyloid beta Positron Emission Tomography in Frontotemporal Lobar Degeneration. Ann Neurol. 2020 Nov; 88 (5):1009-1022 Epub 2020 Sept 12
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  18. Seckin ZI, Whitwell JL, Utianski RL, Botha H, Ali F, Duffy JR, Clark HM, Machulda MM, Jordan LG, Min HK, Lowe VJ, Josephs KA. Ioflupane 123I (DAT scan) SPECT identifies dopamine receptor dysfunction early in the disease course in progressive apraxia of speech. J Neurol. 2020 Sep; 267 (9):2603-2611 Epub 2020 May 09
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  19. Clark HM, Stierwalt JAG, Tosakulwong N, Botha H, Ali F, Whitwell JL, Josephs KA. Dysphagia in Progressive Supranuclear Palsy. Dysphagia. 2020 Aug; 35 (4):667-676 Epub 2019 Nov 01
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  20. Utianski RL, Botha H, Whitwell JL, Martin PR, Schwarz CG, Duffy JR, Clark HM, Spychalla AJ, Senjem ML, Petersen RC, Knopman DS, Jack CR Jr, Lowe VJ, Josephs KA. Longitudinal flortaucipir ([(18)F]AV-1451) PET uptake in semantic dementia. Neurobiol Aging. 2020 Aug; 92:135-140 Epub 2020 Apr 18
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  21. Utianski RL, Martin PR, Botha H, Schwarz CG, Duffy JR, Petersen RC, Knopman DS, Clark HM, Butts AM, Machulda MM, Jack CR Jr, Lowe VJ, Whitwell JL, Josephs KA. Longitudinal flortaucipir ([(18)F]AV-1451) PET imaging in primary progressive apraxia of speech. Cortex. 2020 Mar; 124:33-43 Epub 2019 Nov 19
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  22. Clark HM, Utianski RL, Duffy JR, Strand EA, Botha H, Josephs KA, Whitwell JL. Western Aphasia Battery-Revised Profiles in Primary Progressive Aphasia and Primary Progressive Apraxia of Speech. Am J Speech Lang Pathol. 2020 Feb 21; 29 (1S):498-510 Epub 2019 Oct 22
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  23. Whitwell JL, Tosakulwong N, Botha H, Ali F, Clark HM, Duffy JR, Utianski RL, Stevens CA, Weigand SD, Schwarz CG, Senjem ML, Jack CR, Lowe VJ, Ahlskog JE, Dickson DW, Josephs KA. Brain volume and flortaucipir analysis of progressive supranuclear palsy clinical variants. Neuroimage Clin. 2020; 25:102152 Epub 2019 Dec 28
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  24. Whitwell JL, Tosakulwong N, Weigand SD, Graff-Radford J, Duffy JR, Clark HM, Machulda MM, Botha H, Utianski RL, Schwarz CG, Senjem ML, Strand EA, Ertekin-Taner N, Jack CR, Lowe VJ, Josephs KA. Longitudinal Amyloid-beta PET in Atypical Alzheimer's Disease and Frontotemporal Lobar Degeneration. J Alzheimers Dis. 2020; 74 (1):377-389
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  25. Utianski RL, Botha H, Martin PR, Schwarz CG, Duffy JR, Clark HM, Machulda MM, Butts AM, Lowe VJ, Jack CR Jr, Senjem ML, Spychalla AJ, Whitwell JL, Josephs KA. Clinical and neuroimaging characteristics of clinically unclassifiable primary progressive aphasia. Brain Lang. 2019 Oct; 197:104676 Epub 2019 Aug 13
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  26. Tetzloff KA, Duffy JR, Clark HM, Utianski RL, Strand EA, Machulda MM, Botha H, Martin PR, Schwarz CG, Senjem ML, Reid RI, Gunter JL, Spychalla AJ, Knopman DS, Petersen RC, Jack CR, Lowe VJ, Josephs KA, Whitwell JL. Progressive agrammatic aphasia without apraxia of speech as a distinct syndrome. Brain. 2019 Aug 1; 142 (8):2466-2482
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  27. Utianski RL, Duffy JR, Clark HM, Machulda MM, Dickson DW, Whitwell JL, Josephs KA. Prominent auditory deficits in primary progressive aphasia: A case study. Cortex. 2019 Aug; 117:396-406 Epub 2019 Feb 21
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  28. Whitwell JL, Stevens CA, Duffy JR, Clark HM, Machulda MM, Strand EA, Martin PR, Utianski RL, Botha H, Spychalla AJ, Senjem ML, Schwarz CG, Jack CR Jr, Ali F, Hassan A, Josephs KA. An Evaluation of the Progressive Supranuclear Palsy Speech/Language Variant. Mov Disord Clin Pract. 2019 Jul; 6 (6):452-461 Epub 2019 May 29
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  29. Whitwell JL, Martin PR, Duffy JR, Clark HM, Machulda MM, Schwarz CG, Weigand SD, Sintini I, Senjem ML, Ertekin-Taner N, Botha H, Utianski RL, Graff-Radford J, Jones DT, Boeve BF, Knopman DS, Petersen RC, Jack CR Jr, Lowe VJ, Josephs KA. The influence of beta-amyloid on [(18)F]AV-1451 in semantic variant of primary progressive aphasia. Neurology. 2019 Feb 12; 92 (7):e710-e722 Epub 2019 Jan 11
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  30. Utianski RL, Caviness JN, Worrell GA, Duffy JR, Clark HM, Machulda MM, Whitwell JL, Josephs KA. Electroencephalography in Primary Progressive Aphasia and Apraxia of Speech. Aphasiology. 2019; 33 (11):1410-1417 Epub 2018 Nov 16
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  31. Utianski RL, Botha H, Duffy JR, Clark HM, Martin PR, Butts AM, Machulda MM, Whitwell JL, Josephs KA. Rapid rate on quasi-speech tasks in the semantic variant of primary progressive aphasia: A non-motor phenomenon? J Acoust Soc Am. 2018 Dec; 144 (6):3364
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  32. Utianski RL, Duffy JR, Clark HM, Strand EA, Boland SM, Machulda MM, Whitwell JL, Josephs KA. Clinical Progression in Four Cases of Primary Progressive Apraxia of Speech. Am J Speech Lang Pathol. 2018 Nov 21; 27 (4):1303-1318
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  33. Utianski RL, Whitwell JL, Schwarz CG, Duffy JR, Botha H, Clark HM, Machulda MM, Senjem ML, Knopman DS, Petersen RC, Jack CR Jr, Lowe VJ, Josephs KA. Tau uptake in agrammatic primary progressive aphasia with and without apraxia of speech. Eur J Neurol. 2018 Nov; 25 (11):1352-1357 Epub 2018 July 26
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  34. Tetzloff KA, Whitwell JL, Utianski RL, Duffy JR, Clark HM, Machulda MM, Strand EA, Josephs KA. Quantitative assessment of grammar in amyloid-negative logopenic aphasia. Brain Lang. 2018 Nov; 186:26-31 Epub 2018 Sept 08
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  35. Tetzloff KA, Utianski RL, Duffy JR, Clark HM, Strand EA, Josephs KA, Whitwell JL. Quantitative Analysis of Agrammatism in Agrammatic Primary Progressive Aphasia and Dominant Apraxia of Speech. J Speech Lang Hear Res. 2018 Sep 19; 61 (9):2337-2346
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  36. Utianski RL, Duffy JR, Clark HM, Strand EA, Botha H, Schwarz CG, Machulda MM, Senjem ML, Spychalla AJ, Jack CR Jr, Petersen RC, Lowe VJ, Whitwell JL, Josephs KA. Prosodic and phonetic subtypes of primary progressive apraxia of speech. Brain Lang. 2018 Sep; 184:54-65 Epub 2018 July 04
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  37. Josephs KA, Martin PR, Botha H, Schwarz CG, Duffy JR, Clark HM, Machulda MM, Graff-Radford J, Weigand SD, Senjem ML, Utianski RL, Drubach DA, Boeve BF, Jones DT, Knopman DS, Petersen RC, Jack CR Jr, Lowe VJ, Whitwell JL. [(18) F]AV-1451 tau-PET and primary progressive aphasia. Ann Neurol. 2018 Mar; 83 (3):599-611 Epub 2018 Mar 13
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  38. Utianski RL, Whitwell JL, Schwarz CG, Senjem ML, Tosakulwong N, Duffy JR, Clark HM, Machulda MM, Petersen RC, Jack CR Jr, Lowe VJ, Josephs KA. Tau-PET imaging with [18F]AV-1451 in primary progressive apraxia of speech. Cortex. 2018 Feb; 99:358-374 Epub 2018 Jan 02
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  39. Botha H, Utianski RL, Whitwell JL, Duffy JR, Clark HM, Strand EA, Machulda MM, Tosakulwong N, Knopman DS, Petersen RC, Jack CR Jr, Josephs KA, Jones DT. Disrupted functional connectivity in primary progressive apraxia of speech. Neuroimage Clin. 2018; 18:617-629 Epub 2018 Mar 03
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  40. Tetzloff KA, Duffy JR, Clark HM, Strand EA, Machulda MM, Schwarz CG, Senjem ML, Reid RI, Spychalla AJ, Tosakulwong N, Lowe VJ, Jack CR Jr, Josephs KA, Whitwell JL. Longitudinal structural and molecular neuroimaging in agrammatic primary progressive aphasia. Brain. 2018 Jan 1; 141 (1):302-317
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  41. Tetzloff KA, Graff-Radford J, Martin PR, Tosakulwong N, Machulda MM, Duffy JR, Clark HM, Senjem ML, Schwarz CG, Spychalla AJ, Drubach DA, Jack CR, Lowe VJ, Josephs KA, Whitwell JL. Regional Distribution, Asymmetry, and Clinical Correlates of Tau Uptake on [18F]AV-1451 PET in Atypical Alzheimer's Disease. J Alzheimers Dis. 2018; 62 (4):1713-1724
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  42. Owens TE, Machulda MM, Duffy JR, Strand EA, Clark HM, Boland S, Martin PR, Lowe VJ, Jack CR, Whitwell JL, Josephs KA. Patterns of neuropsychological dysfunction and cortical volume changes in logopenic aphasia Journal Of Alzheimers Disease. 2018; 66 (3):1015-25
  43. Solomon NP, Makashay MJ, Helou LB, Clark HM. Neurogenic Orofacial Weakness and Speech in Adults With Dysarthria. Am J Speech Lang Pathol. 2017 Aug 15; 26 (3):951-960
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  44. Duffy JR, Hanley H, Utianski R, Clark H, Strand E, Josephs KA, Whitwell JL. Temporal acoustic measures distinguish primary progressive apraxia of speech from primary progressive aphasia. Brain Lang. 2017 May; 168:84-94 Epub 2017 Feb 07
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  45. Whitwell JL, Duffy JR, Machulda MM, Clark HM, Strand EA, Senjem ML, Gunter JL, Spychalla AJ, Petersen RC, Jack CR Jr, Josephs KA. Tracking the development of agrammatic aphasia: A tensor-based morphometry study. Cortex. 2017 May; 90:138-148 Epub 2016 Sept 30
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  46. Barkmeier-Kraemer JM, Clark HM. Speech-Language Pathology Evaluation and Management of Hyperkinetic Disorders Affecting Speech and Swallowing Function. Tremor Other Hyperkinet Mov (N Y). 2017; 7:489 Epub 2017 Sept 21
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  47. Dietsch AM, Clark HM, Steiner JN, Solomon NP. Effects of age, sex, and body position on orofacial muscle tone in healthy adults. Journal of Speech, Language & Hearing Research. 2015 Aug; 58(4):1145-50.
  48. Duffy JR, Strand EA, Clark H, Machulda M, Whitwell JL, Josephs KA. Primary progressive apraxia of speech: Clinical features and acoustic and neurologic correlates. Am J Speech Lang Pathol. 2015; 24(2):88-100.
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  49. Tobin WO, Strand EA, Clark HM, Lowe VJ, Robertson CE, Pittock SJ. NMDA receptor encephalitis causing reversible caudate changes on MRI and PET imaging. Neurol Clin Pract. 2014 Dec; 4 (6):470-473
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  50. Clark HM, Shelton N. Training effects of the effortful swallow under three exercise conditions. Dysphagia. 2014 Oct; 29 (5):553-63 Epub 2014 June 10
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  51. Strand EA, Duffy JR, Clark HM, Josephs K. The Apraxia of Speech Rating Scale: a tool for diagnosis and description of apraxia of speech. J Commun Disord. 2014 Sep-Oct; 51:43-50 Epub 2014 July 14
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  52. Clark HM, Duffy JR, Whitwell JL, Ahlskog JE, Sorenson EJ, Josephs KA. Clinical and imaging characterization of progressive spastic dysarthria. Eur J Neurol. 2014 Mar; 21 (3):368-76 Epub 2013 Sept 19
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  53. Clark HM, Anderson CC, Hietpas F. Volumes of discrete sips from straws of varying internal diameters. Am J Speech Lang Pathol. 2014 Feb; 23: (1)84-9.
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  54. Dietsch AM, Solomon NP, Sharkey LA, Duffy JR, Strand EA, Clark HM. Perceptual and instrumental assessments of orofacial muscle tone in dysarthric and normal speakers. J Rehabil Res Dev. 2014; 51(7):1127-42.
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  55. Clark H. Muscle isolations. ASHA Leader. 2013; 18(10 Oct).
  56. Clark HM, Shelton N. Negative Pressure and Muscle Activity during Discrete Sips from High Resistance Straws. International Journal of Orofacial Myology.2013;39:4-11.
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  57. Clark HM. Specificity of training in the lingual musculature. J Speech Lang Hear Res. 2012 Apr; 55(2):657-67. Epub 2012 Jan 03.
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  58. Clark HM, Solomon NP. Age and sex differences in orofacial strength. Dysphagia. 2012 Mar; 27(1):2-9. Epub 2011 Feb 25.
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  59. Clark HM, Solomon NP. Submental muscle tissue compliance during relaxation, contraction, and after tone-modification interventions. Int J Orofacial Myology. 2010 Nov; 36:6-15.
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  60. Arvedson J, Clark H, Lazarus C, Schooling T, Frymark T. The effects of oral-motor exercises on swallowing in children: an evidence-based systematic review. Dev Med Child Neurol. 2010 Nov; 52(11):1000-13.
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  61. Arvedson J, Clark H, Lazarus C, Schooling T, Frymark T. Evidence-based systematic review: effects of oral motor interventions on feeding and swallowing in preterm infants. Am J Speech Lang Pathol. 2010 Nov; 19(4):321-40. Epub 2010 Jul 9.
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  62. Solomon NP, Clark HM. Quantifying orofacial muscle stiffness using damped oscillation. Journal of Medical Speech-Language Pathology. 2010; 18:120-24.
  63. Clark H, Lazarus C, Arvedson J, Schooling T, Frymark T. Evidence-based systematic review: effects of neuromuscular electrical stimulation on swallowing and neural activation. Am J Speech Lang Pathol. 2009 Nov; 18(4):361-75. Epub 2009 Sep 02.
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  64. Clark HM, O'Brien K, Calleja A, Corrie SN. Effects of directional exercise on lingual strength. J Speech Lang Hear Res. 2009 Aug; 52(4):1034-47.
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  65. Clark HM. The role of strength training in speech sound disorders. Semin Speech Lang. 2008 Nov; 29(4):276-83. Epub 2008 Dec 04.
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  66. Robin DA, Jacks A, Hageman C, Clark HM, Woodworth G. Visuomotor tracking abilities of speakers with apraxia of speech or conduction aphasia. Brain Lang. 2008 Aug; 106(2):98-106. Epub 2008 Jun 16.
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  67. Solomon NP, Clark HM, Makashay MJ, Newman LA. Assessment of orofacial strength in adults with dysarthria Journal of Medical Speech-Language Pathology. 2008; 16:251-8.
  68. Clark HM. Neuromuscular treatments for speech and swallowing: a tutorial. Am J Speech Lang Pathol. 2003 Nov; 12(4):400-15.
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  69. Clark HM, Henson PA, Barber WD, Stierwalt JA, Sherrill M. Relationships among subjective and objective measures of tongue strength and oral phase swallowing impairments. Am J Speech Lang Pathol. 2003 Feb; 12 (1):40-50
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  70. Clark HM, Clark NE. Strategic tool selection in distance education: general guidelines and a case example. American Association of Behavioral and Social Sciences Journal. 2002; Winter:1 - 8.
  71. Clark HM, Robin DA, McCullagh G, Schmidt RA. Motor control in children and adults during a non-speech oral task. J Speech Lang Hear Res. 2001 Oct; 44(5):1015-25.
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  72. Clark HM, Robin DA. Generalized motor programmes and parameterization in apraxia of speech and conduction aphasia Aphasiology. 1998; 12:699-713.
PST-20226860