Dr. Samadder's focus are in the areas of hereditary cancer syndromes and endoscopic oncology.

He directs the high risk cancer clinic at Mayo Clinic in Arizona, which provides genetic consultation and testing to patients with early onset cancer, rare cancers and hereditary cancers. Specifically this practice provides clinical management to patients with an inherited cancer syndrome, including (but not limited to) those with Lynch syndrome, FAP, MAP, Li Fraumeni syndrome, BRCA syndromes or any other cancer genetic syndrome. This clinic will provide patients with a single point of contact for all of their genetic testing and cancer screening, including genetic screening of relatives.

His research focusses on the genetic epidemiology and outcomes of patients with hereditary cancer syndromes.

Dr. Samadder is also leading multiple clinical trials using medications to prevent cancers in these patients. He is also leading efforts to increase genetic evaluation and testing of cancer patients throughout the entire Mayo health system.