Publications Print Al-Abcha A, Saleh G, Al-Halaseh S, Naser J, Simard T, Thaden J, Pislaru S, Eleid M, Guerrero M, Alkhouli M, Rihal CS, Padang R, Hibbert B. Natural History and Outcomes of Patients With Moderate and Moderate-Severe Mitral Regurgitation. JACC Adv. 2026 Aug; 5 (8):103057 Epub 2026 July 23 View PubMed Naser JA, Massad F, Al-Abcha A, Gerberi D, Pislaru SV, Nkomo VT, Thaden JJ, Wang Z, Cavalcante JL, Pellikka PA, Michelena HI, Enriquez-Sarano M. Natural history of asymptomatic moderate or severe aortic regurgitation: a systematic review and meta-analysis. Heart. 2026 May 26; 112 (12):646-657 View PubMed Alabdaljabar MS, Al-Abcha A, Alkhouli M, Hibbert B, Liu XK, Simard T, Van Houten H, Yao X, Del-Carpio Munoz F, Melduni RM, Noseworthy PA, Rushlow DR, Friedman P, Killu AM. Outcomes of Left Atrial Appendage Occlusion in Patients With Hypertrophic Cardiomyopathy, Rheumatic Heart Disease, and Cardiac Amyloidosis. JACC Clin Electrophysiol. 2026 May; 12 (5):1089-1101 Epub 2026 Jan 22 View PubMed Killu AM, Alabdaljabar MS, Al-Abcha AK, Alkhouli M, Hibbert B, Liu X, Simard TJ, Van Houten HK, Yao X, Del-Carpio Munoz F, Melduni RM, Noseworthy PA, Rushlow DR, Friedman PA. Outcomes of left atrial appendage occlusion in patients with Hypertrophic Cardiomyopathy, Rheumatic Heart Disease and Cardiac Amyloid JACC Clinical Electrophysiology. 2026. Prosperi-Porta G, Al-Abcha A, Simard T, Hibbert B, Abdel-Razek O. Up-to-date review on concomitant mitral transcatheter edge-to-edge repair and left atrial appendage occlusion. Future Cardiol. 2026 Jan; 22 (1):65-73 Epub 2025 Aug 04 View PubMed Rivera FB, Tsai CM, Pine PLS, Tesoro N, Magalong JV, Bantayan NRB, Lin CJ, Tangco GA, Al-Abcha A, Singh M, Guerrero M. Valvular Heart Disease Interventional Trials From 2000 to 2024: A Systematic Review. JACC Adv. 2026 Jan; 5 (1):102384 Epub 2025 Nov 29 View PubMed Quelal Analuisa K, Challa A, Lane C, Al-Abcha A, George I, Whisenant BK, Satler LF, Makkar RR, Mahoney PD, Zahr FE, Golwala H, Shah PB, Inglessis-Azuaje I, Waggoner T, Muhammad K, Eng MH, Kaptzan T, Lewis B, Thaden J, Bird J, Williamson EE, Collins J, Eleid MF, Oh JK, Guerrero ME. Mitral Annular Calcification Score Determined by 3-D Transesophageal Echocardiography vs Cardiac Computed Tomography. JACC Adv. 2026 Jan; 5 (1):102427 Epub 2025 Dec 17 View PubMed Al-Abcha A, Lim DS, Hausleiter J, Smith RL, Zahr F, Chadderdon S, Makkar R, Makar MM, von Bardeleben RS, Ruf TF, Gossler T, Kipperman RM, Rassi AN, Ku IA, Nabauer M, Szerlip M, Wang Z, Goldman S, Hawthorne KM, Koulogiannis K, Marcoff L, Gillam LD, Guerrero ME, CLASP IID Pivotal Trial Investigators. 1-Year Outcomes After Transcatheter Edge-to-Edge Repair in Degenerative MR Stratified by Extent of Cardiac Damage. JACC Cardiovasc Interv. 2025 Nov 10; 18 (21):2596-2611 View PubMed Al-Abcha A, Saleh G, Sledge H, Abbasi M, Ismayl M, Killu AM, Simard T, Liu X, Hibbert B, Friedman PA, Siontis KC, Alkhouli M. Outcomes of Stroke Prevention Strategies in Patients With Atrial Fibrillation and End-Stage Renal Disease. JACC Cardiovasc Interv. 2025 Nov 10; 18 (21):2614-2624 Epub 2025 Oct 14 View PubMed Saleh G, Al-Abcha A, Chaaban K, Adi MZ, Tweet M, Collins JD, Alkhouli M, Gulati R. Concomitant Takotsubo Cardiomyopathy and Spontaneous Coronary Artery Dissection: Exploring the Role of Cardiac Mechanics on Coronary Disruption. JACC Cardiovasc Imaging. 2025 Oct; 18 (10):1161-1166 Epub 2025 Aug 05 View PubMed Ghorbanzadeh A, Lane C, Al-Abcha A, Ortega-Macias A, Eleid M, Wang DD, George I, Kodali S, Tommaso CL, Krause P, Berger R, Palacios I, Makkar R, Satler L, Kaptzan T, Lewis B, Thaden J, Oh J, Hahn RT, Rihal C, Guerrero M. Outcomes of Iatrogenic Atrial Septal Defect Closure After Transseptal Transcatheter Mitral Valve Replacement in the Mitral Implantation of Transcatheter Valves (MITRAL) Trial. Struct Heart. 2025 Oct; 9 (10):100482 Epub 2025 Aug 27 View PubMed Figueiral M, Al-Abcha A, Castrichini M, Pruthi RK, Pereira N. Hepatic Cytochrome P450 Enzymatic System Interaction With Platelet Function and Cardiovascular Outcomes-Pharmacogenomic Impact on Inter-Organ Communication. Compr Physiol. 2025 Aug; 15 (4):e70027 View PubMed Al-Abcha A, Simard T, Tweet MS, Prasad A, Alkhouli M, Bell MR, Gulati R. Optical Coherence Tomography for Spontaneous Coronary Artery Dissection Assessment: The Flush-Free OCT Technique. JACC Case Rep. 2025 Jul 30; 30 (21):104398 View PubMed Hunter D, Sularz A, Adi MZ, Al-Abcha A, Matin A, Bakharev A, Vanmeter D, Alkhouli M, Hevesi S. Magnetocardiography in Diagnosis of Stress-Induced Cardiomyopathy. JACC Case Rep. 2025 Jul 9; 30 (18):104037 View PubMed Al-Abcha A, Jain CC, Nishimura RA, Simard TJ, Eleid MF, Hibbert B, Oh JK, Carabello BA, Miranda WR. Exercise Mildly Increases Transaortic Gradients in Aortic Stenosis With Preserved Ejection Fraction: An Invasive Hemodynamic Study. Catheter Cardiovasc Interv. 2025 Jul; 106 (1):181-188 Epub 2025 Apr 09 View PubMed Negm AS, Sularz A, Al-Abcha A, El Shaer A, Ponce AC, Collins JD, Alkhouli M. Tricuspid Regurgitation Assessment Using Cardiac Magnetic Resonance Velocity-Encoded 4-Dimensional Flow. JACC Case Rep. 2025 Jun 11; 30 (14):103608 View PubMed Al-Abcha A, Clay S, Wang L, Prasad RM, Salam MF, Srivastava S, Boumegouas M, Abela GS, Saleh Y, Essa EM. Direct Oral Anticoagulants Versus Warfarin for the Treatment of Left Ventricular Thrombus: A Multicenter Retrospective Observational Study. Am J Cardiol. 2025 Mar 1; 238:21-24 Epub 2024 Nov 24 View PubMed Welle GA, Miller JR, Al-Abcha A, Ehtemami A, Morris JM, Alkhouli M, Hibbert B, Gulati R, Prasad A, Simard T. Virtual Reality Simulation With Integrated Passive Haptics Prototype for Cardiac Catheterization Laboratory Training. J Soc Cardiovasc Angiogr Interv. 2025 Mar; 4 (3Part B):102451 Epub 2024 Dec 10 View PubMed Sularz A, Chavez Ponce A, Al-Abcha A, Simard T, Killu AM, Doshi SK, Alkhouli M. Safety and Feasibility of 3D Intracardiac Echocardiography in Guiding Left Atrial Appendage Occlusion With WATCHMAN FLX. JACC Adv. 2025 Feb; 4 (2):101570 Epub 2025 Jan 13 View PubMed Al-Abcha A, Di Santo P, Rihal CS, Simard T, Hibbert B, Alkhouli M. Outcomes of Combined Left Atrial Appendage Occlusion and Transcatheter Mitral Edge-to-Edge Repair: The WATCH-TEER Study. JACC Adv. 2025 Feb; 4 (2):101541 Epub 2025 Jan 08 View PubMed Abbasi M, Al-Abcha A, Lee AT BS, Lee BS, Scott CG, Guerrero M, Pellikka PA. Progression of Mild Mitral Annulus Calcification to Mitral Valve Dysfunction and Impact on Mortality. J Am Soc Echocardiogr. 2024 Aug; 37 (8):752-755 Epub 2024 Mar 16 View PubMed Al-Abcha A, Abbasi M, El-Am E, Ghorbanzadeh A, Lee A, Scott CG, Thaden JJ, Eleid M, Rihal C, Oh J, Pellikka PA, Guerrero ME. Staging Extramitral Cardiac Damage in Mitral Annular Calcification With Mitral Valve Dysfunction. JACC Cardiovasc Interv. 2024 Jul 8; 17 (13):1577-1590 View PubMed Halboni A, Hamza M, Dayco J, Al-Abcha A, Alhalbouni A, Zghouzi M, Alhusain R, Sattar Y, Alraies MC. Outcomes of Transcatheter Mitral Valve Repair Using the MitraClip System in Patients With Atrial Fibrillation. A Meta-Analysis. Am J Cardiol. 2024 May 15; 219:47-59. Epub 2023 Oct 18. View PubMed Chamberlain AM, Bergeron NP, Al-Abcha AK, Weston SA, Jiang R, Attia ZI, Friedman PA, Gersh BJ, Noseworthy PA, Siontis KC. Postoperative atrial fibrillation: Prediction of subsequent recurrences with clinical risk modeling and artificial intelligence electrocardiography. Cardiovasc Digit Health J. 2024 Apr; 5 (2):111-114 Epub 2024 Feb 24 View PubMed Lo Russo GV, Alarouri HS, Al-Abcha A, Vogl B, Mahayni A, Sularz A, Hatoum H, Collins J, Crestanello JA, Alkhouli M. Association of Bovine Arch Anatomy With Incident Stroke After Transcatheter Aortic Valve Replacement. J Am Heart Assoc. 2024 Feb 20; 13 (4):e032963 Epub 2024 Feb 13 View PubMed Al-Abcha A, Crestanello J, Alkhouli M. 3D-ICE-Guided Repair of a Persistent LVOT Pseudoaneurysm After Aortic Valve Replacement: An Icy Seal. JACC Cardiovasc Interv. 2024 Feb 12; 17 (3):439-440 View PubMed Rivera FB, Choi S, Carado GP, Adizas AV, Bantayan NRB, Loyola GJP, Cha SW, Aparece JP, Rocha AJB, Placino S, Ansay MFM, Mangubat GFE, Mahilum MLP, Al-Abcha A, Suleman N, Shah N, Suboc TMB, Volgman AS. End-Of-Life Care for Patients With End-Stage Heart Failure, Comparisons of International Guidelines. Am J Hosp Palliat Care. 2024 Jan; 41(1):87-98. Epub 2023 Jan 27. View PubMed Ismayl M, Abbasi M, Al-Abcha A, El-Am E, Alkhouli M, Guerrero M, Dispenzieri A, Nkomo VT, Abou Ezzeddine OF, Grogan M, Anavekar NS. Outcomes of transcatheter aortic valve replacement in patients with and without amyloidosis: A nationwide analysis from the United States. Cardiovasc Revasc Med. 2024 Jan; 58:34-42 Epub 2023 July 17 View PubMed Saeed Al-Asad K, Martinez Salazar A, Radwan Y, Wang E, Salam MF, Sabanci R, Saeed M, Halboni A, Al-Abcha A, Abela G. Transcatheter Aortic Valve Replacement in Bicuspid Versus Tricuspid Aortic Valve Stenosis: Meta-Analysis and Systemic Review. Am J Cardiol. 2023 Sep 15; 203:105-112. Epub 2023 Jul 22. View PubMed Al-Abcha A, Alkhouli M, Prasad A, Bell M, Yalamuri S, Lerman A, Gulati R, Simard T. Augmented Reality and Ultrasound-Guided Vascular Access. Circ Cardiovasc Interv. 2023 Sep; 16 (9):e013360 Epub 2023 Aug 31 View PubMed Prathivadhi-Bhayankaram S, Abbasi MA, Ismayl M, Marar RI, Al-Abcha A, El-Am E, Ahmad A, Acevedo AD, Ellauzi R, Villarraga H, Paludo J, Anavekar N. Cardiotoxicities of Novel Therapies in Hematological Malignancies: Monoclonal Antibodies and Enzyme Inhibitors. Curr Probl Cardiol. 2023 Aug; 48(8):101757. Epub 2023 Apr 23. View PubMed Ismayl M, Abbasi MA, Al-Abcha A, Robertson S, El-Am E, Goldsweig AM, Alkhouli M, Guerrero M, Anavekar NS. Outcomes of Transcatheter Aortic Valve Implantation in Nonagenarians and Octogenarians (Analysis from the National Inpatient Sample Database). Am J Cardiol. 2023 Jul 15; 199:59-70 Epub 2023 May 29 View PubMed Saleh A, Al-Abcha A, Pereira N. Pharmacogenetics of cardiovascular drugs. Curr Opin Cardiol. 2023 May 1; 38 (3):207-214 Epub 2023 Mar 28 View PubMed Ismayl M, Abbasi MA, Al-Abcha A, El-Am E, Lundgren S, Goldsweig AM, Anavekar NS. Sodium-Glucose Cotransporter-2 Inhibitors in Heart Failure With Mildly Reduced or Preserved Ejection Fraction: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Curr Probl Cardiol. 2023 May; 48 (5):101597 Epub 2023 Jan 18 View PubMed Ismayl M, Abbasi MA, Al-Abcha A, El-Am E, Walters RW, Goldsweig AM, Alkhouli M, Guerrero M, Anavekar NS. Racial and Ethnic Disparities in the Use and Outcomes of Transcatheter Mitral Valve Replacement: Analysis From the National Inpatient Sample Database. J Am Heart Assoc. 2023 Apr 4; 12 (7):e028999 Epub 2023 Mar 28 View PubMed Saleh A, Al-Abcha A, Pereira N. Pharmacogenetics of cardiovascular drugs. Curr Opin Cardiol. 2023 Mar 28 [Epub ahead of print] View PubMed Rivera FB, Al-Abcha A, Ansay MFM, Magalong JVU, Tang VAS, Ona HM, Miralles KA, Sausa R, Uy RAF, Lerma EV, Collado FMS, McCullough PA, Volgman AS. Transcatheter Aortic Valve Replacement-Associated Acute Kidney Injury: An Update. Cardiorenal Med. 2023; 13(1):143-157. Epub 2023 Feb 17. View PubMed Rivera FB, Cha SW, Aparece JP, Gonzales JST, Salva WFC, Bantayan NRB, Carado GP, Sharma V, Al-Abcha A, Co ML, Collado FMS, Volgman AS. Sex differences in permanent pacemaker implantation after transcatheter aortic valve replacement: a systematic review and meta-analysis. Expert Rev Cardiovasc Ther. 2023 Jul-Dec; 21(9):631-641. Epub 2023 Aug 30. View PubMed Al-Abcha A, Saleh Y, Khan SU, Salazar AM, Zaid S, Abdelkarim O, Halboni A, Abdelfattah OM, Goel SS, Kleiman NS, Guerrero M. Mitral Valve-in-Valve Versus Repeat Surgical Mitral Valve Replacement in Patients With Failed Mitral Bioprostheses. J Soc Cardiovasc Angiogr Interv. 2023 Jan-Feb; 2 (1):100516 Epub 2022 Nov 25 View PubMed Gullapalli K, Prasad RM, Al-Abcha A, Hussain Z, Alsouqi A, Mosalem O, Hrinczenko B. Efficacy and Safety of Direct Oral Anticoagulants in Patients With Antiphospholipid Syndrome: A Systematic Review and Meta-Analysis. Cureus. 2022 Sep; 14 (9):e29449 Epub 2022 Sept 22 View PubMed Baloch ZQ, Abbas SA, Prasad R, Raza SA, Al-Abcha A, Marone L, Ali A. Correlating Toe-Brachial Indices and Angiographically Confirmed Peripheral Artery Disease: A Retrospective Review. Angiology. 2022 Aug; 73 (7):599-605 Epub 2021 Nov 08 View PubMed Prasad RM, Saleh Y, Al-Abcha A, Abdelkarim O, Abdelfattah OM, Abdelnabi M, Almaghraby A, Elwany M, DeBruyn E, Abela GS. Left Atrial Appendage Closure During Cardiac Surgery for Atrial Fibrillation: A Meta-Analysis. Cardiovasc Revasc Med. 2022 Jul; 40:26-36 Epub 2021 Nov 04 View PubMed Srivastava S, Yavari M, Al-Abcha A, Banga S, Abela G. Ventricular non-compaction review. Heart Fail Rev. 2022 Jul; 27 (4):1063-1076 Epub 2021 July 07 View PubMed Saleh Y, Al-Abcha A, Abdelkarim O, Abdelnabi M, Almaghraby A, Kleiman NS. Direct Oral Anticoagulants Versus Vitamin K Antagonists in the Treatment of Left Ventricular Thrombi. Am J Cardiovasc Drugs. 2022 May; 22 (3):231-238 Epub 2021 Nov 05 View PubMed Al-Abcha A, Saleh Y, Elsayed M, Elshafie A, Herzallah K, Baloch ZQ, Banga S, Rayamajhi S, Abela GS. Left Atrial Appendage Closure Versus Oral Anticoagulation in Non-Valvular Atrial Fibrillation: A Systematic Review and Meta-Analysis. Cardiovasc Revasc Med. 2022 Mar; 36:18-24 Epub 2021 Apr 22 View PubMed Boumegouas M, Raju M, Gardiner J, Hammer N, Saleh Y, Al-Abcha A, Kalra A, Abela GS. Interaction between bacteria and cholesterol crystals: Implications for endocarditis and atherosclerosis. PLoS One. 2022; 17 (2):e0263847 Epub 2022 Feb 18 View PubMed Al-Abcha A, Radwan Y, Blais D, Mazzaferri EL Jr, Boudoulas KD, Essa EM, Gumina RJ. Genotype-Guided Use of P2Y12 Inhibitors: A Review of Current State of the Art. Front Cardiovasc Med. 2022; 9:850028 Epub 2022 Mar 23 View PubMed Saleh Y, Al-Abcha A, Abdelkarim O, Elwany M, Abdelfattah OM, Abdelnabi M, Almaghraby A. Meta-Analysis Comparing the Effect of Rivaroxaban Versus Vitamin K Antagonists for Treatment of Left Ventricular Thrombi. Am J Cardiol. 2021 Dec 15; 161:123-125 Epub 2021 Oct 14 View PubMed Prasad RM, Kemnic T, Al-Abcha A, Sharma A, Kavuturu S. Hypersensitivity Pneumonitis From Fire-Retardant Spray in a Patient With Multiple Lung Pathologies and Elevated Immunoglobulin E. Ochsner J. 2021 Winter; 21 (4):425-430 View PubMed Wang L, Pezeshkian K, Rayamajhi S, Herzallah K, Al-Abcha A, Olomu A, Kelly-Blake K, Yu E, Wang DH. Relationship between blood pressure and kidney diseases in large randomized controlled trials: secondary analyses using SPRINT and ACCORD-BP trials. J Hum Hypertens. 2021 Oct; 35 (10):859-869 Epub 2020 Oct 22 View PubMed Criner RN, Al-Abcha A, Lambert AA, Han MK. Lung Diseases Unique to Women. Clin Chest Med. 2021 Sep; 42 (3):507-516 View PubMed Ip RJ, Ali A, Baloch ZQ, Al-Abcha A, Jacob C, Arnautovic J, Boumegouas M, Do S, Meka K, Wilcox M, Ip J. Atrial Fibrillation as a Predictor of Mortality in High Risk COVID-19 Patients: A Multicentre Study of 171 Patients. Heart Lung Circ. 2021 Aug; 30 (8):1151-1156 Epub 2021 Mar 06 View PubMed Al-Abcha A, Wang L, Reilly MJ, Rosenman KD. Work-related asthma in cobalt-exposed workers. J Asthma. 2021 Aug; 58 (8):1032-1041 Epub 2020 May 02 View PubMed Al-Abcha A, Herzallah K, Saleh Y, Mujer M, Abdelkarim O, Abdelnabi M, Almaghraby A, Abela GS. The Role of Direct Oral Anticoagulants Versus Vitamin K Antagonists in the Treatment of Left Ventricular Thrombi: A Meta-Analysis and Systematic Review. Am J Cardiovasc Drugs 2021 Jul; 21 (4):435-441 Epub 2020 Dec 23 View PubMed Al-Abcha A, Saleh Y, Boumegouas M, Prasad R, Herzallah K, Baloch ZQ, Abdelkarim O, Rayamajhi S, Abela GS. Meta-Analysis of Valve-in-Valve Transcatheter Aortic Valve Implantation Versus Redo-surgical Aortic Valve Replacement in Failed Bioprosthetic Aortic Valve. Am J Cardiol. 2021 May 1; 146:74-81 Epub 2021 Jan 31 View PubMed Labaki WW, Xia M, Murray S, Hatt CR, Al-Abcha A, Ferrera MC, Meldrum CA, Keith LA, Galban CJ, Arenberg DA, Curtis JL, Martinez FJ, Kazerooni EA, Han MK. Quantitative Emphysema on Low-Dose CT Imaging of the Chest and Risk of Lung Cancer and Airflow Obstruction: An Analysis of the National Lung Screening Trial. Chest. 2021 May; 159 (5):1812-1820 Epub 2020 Dec 14 View PubMed Al-Abcha A, Saleh Y, Charles L, Prasad R, Baloch ZQ, Hasan MA, Abela GS. Clinical Outcomes of the Self-Expandable Evolut R Valve Versus the Balloon-Expandable SAPIEN 3 Valve in Transcatheter Aortic Valve Implantation: A Meta-Analysis and Systematic Review. Cardiovasc Revasc Med. 2021 Apr; 25:57-62 Epub 2020 Oct 16 View PubMed Prasad RM, Al-Abcha A, Elshafie A, Radwan YA, Baloch ZQ, Abela GS. The rare presentation of the de Winter's pattern: Case report and literature review. Am Heart J Plus. 2021 Mar; 3:100013 Epub 2021 May 26 View PubMed Al-Abcha A, Saleh Y, Mujer M, Herzallah K, Abela GS. Long-Term Outcomes of Left Main Coronary Artery Disease Treated With Drug-Eluting Stents vs Coronary Artery Bypass Grafting: A Meta-Analysis and Systematic Review. Cardiovasc Revasc Med. 2021 Feb; 23:14-19 Epub 2020 July 11 View PubMed Mosalem O, Rous FA, Al-Abcha A, Kherallah S, Burch J. Pyomyositis as an Unusual Presentation of Colonic Adenocarcinoma. Perm J. 2020 Dec; 25:1 View PubMed Mujer MT, Al-Abcha A, Flores J, Saleh Y, Robinson P. A comparison of figure-of-8-suture versus manual compression for venous access closure after cardiac procedures: An updated meta-analysis. Pacing Clin Electrophysiol. 2020 Aug; 43 (8):856-865 Epub 2020 July 20 View PubMed Al-Abcha A, Saleh Y, Mujer M, Boumegouas M, Herzallah K, Charles L, Elkhatib L, Abdelkarim O, Kehdi M, Abela GS. Meta-analysis Examining the Usefulness of Angiotensin Receptor blockers for the Prevention of Aortic Root Dilation in Patients With the Marfan Syndrome. Am J Cardiol. 2020 Aug 1; 128:101-106 Epub 2020 May 19 View PubMed Mujer MT, Al-Abcha A, Saleh Y, Nerusu LA, Boumegouas M, Herzallah K, Chen K. Effect of combined renal denervation and pulmonary vein isolation in atrial fibrillation recurrence in hypertensive patients: A meta-analysis. Pacing Clin Electrophysiol. 2020 Aug; 43 (8):866-874 Epub 2020 July 20 View PubMed Al-Abcha A, Raziq F, Kherallah S, Alratroot A. Mesalamine-induced eosinophilic pleural effusion. BMJ Case Rep. 2020 Apr 16; 13 (4) View PubMed Al-Abcha A, Iftikhar MH, Abu Rous F, Laird-Fick H. Chylothorax: complication attributed to dasatinib use. BMJ Case Rep. 2019 Dec 16; 12 (12) View PubMed PST-20610758 Home Publications