تشمل الاختبارات والإجراءات المستخدمة في تشخيص سرطان لمفومة الخلايا البائية الجلدية:

• الفحص البدني. سيفحص الطبيب الجلد بعناية. وسيبحث عن المؤشرات الأخرى التي قد تعطي مؤشرات لتشخيص الحالة.
• خزعة الجلد. الخزعة هي إجراء طبي يهدف إلى أخذ عينة من الأنسجة لاختبارها في مختبر. وقد يُزيل الطبيب قطعة صغيرة من الجلد المصاب. وتُرسَل هذه العينة إلى المختبر للكشف عن خلايا اللمفومة.
• تحاليل الدم. يمكن تحليل عينة دم للكشف عن خلايا اللمفومة.
• خزعة نخاع العظم. تُفحص عينة من نخاع العظم للكشف عن خلايا اللمفومة.
• الاختبارات التصويرية. يمكن أن تساعد الاختبارات التصويرية الطبيبَ في تقييم الحالة المرَضية. تشمل نماذج الاختبارات التصويرية الأخرى الفحص بالتصوير المقطعي المحوسب، والفحص بالتصوير المقطعي بالإصدار البوزيتروني.

Skin biopsy

A biopsy is a procedure to remove a sample of tissue for testing in a lab. Your healthcare professional may remove a small piece of the affected skin. The sample is tested in a lab to look for lymphoma cells.

Blood tests

Blood tests can sometimes show whether lymphoma cells are present. Blood tests may be used to test for viruses, including HIV, hepatitis B virus and hepatitis C virus. The presence of a virus may affect treatment options. Blood tests also measure levels of lactate dehydrogenase (LDH), which is often higher in people with systemic lymphoma.

Bone marrow biopsy and aspiration

Bone marrow biopsy and aspiration are procedures that involve collecting cells from the bone marrow. The cells are sent for testing.

In a bone marrow aspiration, a needle is used to draw a sample of the fluid. In a bone marrow biopsy, a needle is used to collect a small amount of the solid tissue. The samples most often come from the hip bone. Your bone marrow may be tested to look for lymphoma cells.

Imaging tests

Imaging tests make pictures of the body. They can show if the lymphoma is only in the skin. Tests might include CT and positron emission tomography (PET) scans.

Testing lymphoma cells in the lab

Lymphoma cells collected from a biopsy or a bone marrow aspiration and biopsy go to a lab for testing. In the lab, specialized tests look for specific things about the cells. The healthcare team uses the results to determine the type of lymphoma that you have.

To decide whether the cells are cutaneous B-cell lymphoma cells, the healthcare professionals in the lab look for:

• Proteins on the surface of the cancer cells. Cutaneous B-cell lymphoma cells have certain proteins on their surfaces that help identify them. These proteins are known as markers. These markers can help identify the type of cutaneous B-cell lymphoma.
• Changes in the cancer cell DNA. Cancer happens when cells have changes in their DNA. Lab tests can show which DNA changes are present in the lymphoma cells.