用于诊断皮肤 B 细胞淋巴瘤的检查和医疗程序包括：

• 体格检查。 医疗护理专业人员会仔细检查您的皮肤。医疗护理专业人员会寻找其他可为诊断提供线索的体征。
• 皮肤活检。 活检是一项采集组织样本并在实验室中进行检测的医疗程序。医疗护理专业人员可能会切除一小块受影响的皮肤样本。然后将样本送至实验室，检查有无淋巴瘤细胞。
• 血液检查。 可能分析您的血液样本，检查淋巴瘤细胞。
• 骨髓活检。 可能检测您的骨髓样本，检查淋巴瘤细胞。
• 成像检查。 成像检查有助于医疗护理专业人员评估您的状况。成像检查示例包括计算机体层成像扫描（也称为 CT 扫描）和正电子发射体层成像扫描（也称为 PET 扫描）。

Skin biopsy

A biopsy is a procedure to remove a sample of tissue for testing in a lab. Your healthcare professional may remove a small piece of the affected skin. The sample is tested in a lab to look for lymphoma cells.

Blood tests

Blood tests can sometimes show whether lymphoma cells are present. Blood tests may be used to test for viruses, including HIV, hepatitis B virus and hepatitis C virus. The presence of a virus may affect treatment options. Blood tests also measure levels of lactate dehydrogenase (LDH), which is often higher in people with systemic lymphoma.

Bone marrow biopsy and aspiration

Bone marrow biopsy and aspiration are procedures that involve collecting cells from the bone marrow. The cells are sent for testing.

In a bone marrow aspiration, a needle is used to draw a sample of the fluid. In a bone marrow biopsy, a needle is used to collect a small amount of the solid tissue. The samples most often come from the hip bone. Your bone marrow may be tested to look for lymphoma cells.

Imaging tests

Imaging tests make pictures of the body. They can show if the lymphoma is only in the skin. Tests might include CT and positron emission tomography (PET) scans.

Testing lymphoma cells in the lab

Lymphoma cells collected from a biopsy or a bone marrow aspiration and biopsy go to a lab for testing. In the lab, specialized tests look for specific things about the cells. The healthcare team uses the results to determine the type of lymphoma that you have.

To decide whether the cells are cutaneous B-cell lymphoma cells, the healthcare professionals in the lab look for:

• Proteins on the surface of the cancer cells. Cutaneous B-cell lymphoma cells have certain proteins on their surfaces that help identify them. These proteins are known as markers. These markers can help identify the type of cutaneous B-cell lymphoma.
• Changes in the cancer cell DNA. Cancer happens when cells have changes in their DNA. Lab tests can show which DNA changes are present in the lymphoma cells.