طب القلب والأوعية الدموية

بالأسفل التجارب السريرية الحالية.

غربل قائمة الدراسات هذه بالموقع والحالة وغيرها.

1. International Bicuspid Aortic Valve Consortium (BAVCon)

   Rochester, Minn.

   Bicuspid aortic valve (BAV) disease is the most frequent congenital cardiac malformation, occurring in 0.5-1.2% of the US population. In young adults, it is generally a benign abnormality; but in older adults it is associated with thoracic aortic aneurysm or dissection in 20-30% of those with BAV. BAV is strongly associated with early development of aortic valve calcification or incompetence in >50% of BAV patients, and accounts for ~40% of the >30,000 aortic valve replacements (AVR) performed in the US each year. Yet, we know little of the etiology, cellular events and modifiers of progression of BAV to calcific aortic valve disease and we still do not understand the genetic cause(s) of BAV despite evidence for its high heritability.

   The Specific Aims of this study are:

   1. To identify the genetic causes of bicuspid aortic valve disease and its associated thoracic aortic disease.

   2. To identify potential pathways to predict the clinical course of BAV disease and for treating human BAV disease.

   To achieve these aims, we have created the International Bicuspid Aortic Valve Consortium (BAVCon), a consortium of institutions with cohorts of BAV patients and the expertise to fulfill the performance of these aims.

2. Mayo Clinic Cardiovascular Disease Biobank

   Rochester, Minn.

   The purpose of this study is to determine the innate immune, cell death and oxidative stress changes in the myocardium, and aorta of patients with heart failure compared to patients with normal hearts.

3. Identification of Novel Genetic Variants and Biomarkers of Disease Progression in Arrhythmogenic Cardiomyopathy

   Rochester, Minn.

   The purpose of this study is to identify hereditary causes of cardiomyopathy.

4. A Study of the Mayo Clinic College of Medicine Ultrasound System

   Rochester, Minn.

   The purpose of this study is is to assess the EPIQ-Affiniti and NG Compact ultrasound systems in a clinical environment and collect clinical data and feedback when compared to the site’s standard ultrasound system.

5. Genotype-Phenotype Correlation in Cardiovascular Disease

   Rochester, Minn.

   This research study is being done to help characterize cardiovascular disease and improve diagnostic tests.

   OBJECTIVES

   1. To understand the pathogenesis, molecular mechanisms, and disease progression of heritable cardiovascular disease

   2. To evaluate the incidence of occult heritable cardiovascular disease in various populations.

   3. To correlate imaging and pathological phenotype with genotype to the ends described above.

6. Unipedal Stance Time With Frailty Scores in Transcatheter Aortic Valve Replacement Patients

   Rochester, Minn.

   The objective of this study is to compare the unipedal stance time with serum albumin, 5-meter walk test and KATZ questionnaire findings as frailty scores in transcatheter aortic valve replacement (TAVR) patients.

    

    

7. A Study to Assess the Role of Biomarkers in Risk Stratification in Adults with Congenital Heart Disease

   Rochester, Minn.

   The purporse of this study is to determine if biomarker assay obtained at baseline can predict future risk of cardiovascular adverse events, and to  determine if temporal changes in biomarker levels can provide a better risk prediction compared to biomarker assay obtained at baseline.

8. Echocardiographic Measures of Pulmonary Vascular Distensibility and Effects on Lung Diffusing Capacity

   Rochester, Minn.

   The purpose of this study is to determine if the change in pulmonary vascular compliance with positional changes (upright, supine, and Trendelenburg position) is different in younger versus older individuals.

9. A Study to Evaluate Potential Myocardial Injury Following Magnetic Resonance Imaging (MRI)

   Rochester, Minn.

   The purpose of this study is to prospectively determine if magnetic resonance imaging (MRI) in patients with cardiac implantable electronic devices (CIED) results in myocardial injury as assessed by changes in high sensitivity cardiac troponin T (hs-cTnT) assay. This will be done by comparing pre-and-post MRI hs-cTnT levels in these patients.

10. ARTIST: Aortic Regurgitation Trial Investigating Surgery Versus Trilogy™

    Rochester, Minn.

    To demonstrate non-inferiority of the Trilogy Transcatheter Heart Valve (THV) System compared with surgical aortic valve replacement (SAVR) for treatment of subjects with clinically significant native aortic regurgitation (AR)