Katherine B. Geiersbach, M.D.

  1. Pathologist

المنشورات

  1. Geiersbach KB, Sill DR, Del Rosario KM, Meyer RG, Spears GM, Yuhas JA, Sukov WR, Jenkins RB, Ocal IT, Mounajjed T, Chen B. Detailed Reanalysis of 500 Breast Cancers With Equivocal HER2 Immunohistochemistry and Borderline ERBB2 Fluorescence In Situ Hybridization Results. Am J Clin Pathol. 2021 Oct 13; 156 (5):886-894
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  2. Geiersbach KB, Sill DR, Meyer RG, Yuhas JA, Sukov WR, Mounajjed T, Carter JM, Jenkins RB, Chen B. HER2 Testing for Breast Cancer in the Genomics Laboratory: A Sea Change for Fluorescence In Situ Hybridization. Arch Pathol Lab Med. 2021 Jul 1; 145 (7):883-886
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  3. Zhao Y, Yu H, Ida CM, Halling KC, Kipp BR, Geiersbach K, Rumilla KM, Gupta S, Lin MT, Zheng G. Assessment of RAS Dependency for BRAF Alterations Using Cancer Genomic Databases. JAMA Netw Open. 2021 Jan 4; 4 (1):e2035479 Epub 2021 Jan 04
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  4. Geiersbach KB, Chen H, Emmadi R, Haskell GT, Lu X, Liu YJ, Swisshelm K. Current concepts in breast cancer genomics: An evidence based review by the CGC breast cancer working group. Cancer Genet. 2020 Jun; 244:11-20 Epub 2020 Feb 08
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  5. Geiersbach KB, Meyer RG, Sill DR, Mounajjed T, Chen B, Sukov WR, Jenkins RB. Working Up Group 4 Equivocal HER2 Samples Tested by Fluorescence in Situ Hybridization in a Reference Laboratory Setting: Past, Present, and Future. J Clin Oncol. 2020 Jan 10; 38(2):175-176. Epub 2019 Nov 26.
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  6. Blackburn PR, Davila JI, Jackson RA, Fadra N, Atiq MA, Pitel BA, Nair AA, VanDeWalker TJ, Hessler MG, Hovel SK, Wehrs RN, Fritchie KJ, Jenkins RB, Halling KC, Geiersbach KB. RNA sequencing identifies a novel USP9X-USP6 promoter swap gene fusion in a primary aneurysmal bone cyst. Genes Chromosomes Cancer. 2019 Aug; 58 (8):589-594 Epub 2019 Mar 06
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  7. Aypar U, Smoley SA, Pitel BA, Pearce KE, Zenka RM, Vasmatzis G, Johnson SH, Smadbeck JB, Peterson JF, Geiersbach KB, Van Dyke DL, Thorland EC, Jenkins RB, Ketterling RP, Greipp PT, Kearney HM, Hoppman NL, Baughn LB. Mate pair sequencing improves detection of genomic abnormalities in acute myeloid leukemia. Eur J Haematol. 2019 Jan; 102 (1):87-96 Epub 2018 Nov 22
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  8. Geiersbach KB, Bridge JA, Dolan M, Jennings LJ, Persons DL, Souers RJ, Tsuchiya KD, Vasalos PH, Moncur JT. Comparative Performance of Breast Cancer Human Epidermal Growth Factor Receptor 2 Fluorescence In Situ Hybridization and Brightfield In Situ Hybridization on College of American Pathologists Proficiency Tests. Arch Pathol Lab Med. 2018 Oct; 142 (10):1254-1259 Epub 2018 May 07
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  9. Vasmatzis G, Wang X, Smadbeck JB, Murphy SJ, Geiersbach KB, Johnson SH, Gaitatzes AG, Asmann YW, Kosari F, Borad MJ, Serie DJ, McLaughlin SA, Kachergus JM, Necela BM, Thompson EA. Chromoanasynthesis is a common mechanism that leads to ERBB2 amplifications in a cohort of early stage HER2(+) breast cancer samples. BMC Cancer. 2018 Jul 13; 18 (1):738 Epub 2018 July 13
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  10. Stewart RL, Gulbahce EH, Geiersbach KB, Downs-Kelly E. Reply to Commentary on 'HER2 immunohistochemical and fluorescence in situ hybridization discordances in invasive breast carcinoma with micropapillary features'. Mod Pathol 2018 Apr; 31 (4):686
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  11. Haskell GT, Liu YJ, Chen H, Chen B, Meyer RG, Yuhas JA, Geiersbach KB. Integrated Analysis of HER2 Copy Number by Cytogenomic Microarray in Breast Cancers With Nonclassical In Situ Hybridization Results. Am J Clin Pathol. 2018 Jan 29; 149 (2):135-147
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  12. El Jabbour T, Ross JS, Sheehan CE, Affolter KE, Geiersbach KB, Boguniewicz A, Ainechi S, Bronner MP, Jones DM, Lee H. PD-L1 protein expression in tumour cells and immune cells in mismatch repair protein-deficient and -proficient colorectal cancer: the foundation study using the SP142 antibody and whole section immunohistochemistry. J Clin Pathol. 2018 Jan; 71 (1):46-51 Epub 2017 June 30
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  13. Stewart RL, Caron JE, Gulbahce EH, Factor RE, Geiersbach KB, Downs-Kelly E. HER2 immunohistochemical and fluorescence in situ hybridization discordances in invasive breast carcinoma with micropapillary features. Mod Pathol. 2017 Nov; 30 (11):1561-1566 Epub 2017 July 28
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  14. Hui L, Geiersbach KB, Downs-Kelly E, Gulbahce HE. RAI1 Alternate Probe Identifies Additional Breast Cancer Cases as Amplified Following Equivocal HER2 Fluorescence In Situ Hybridization Testing: Experience From a National Reference Laboratory. Arch Pathol Lab Med. 2017 Feb; 141: (2)274-278.
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  15. Zhou W, Geiersbach K, Chadwick B. Rapid removal of cytology slide coverslips for DNA and RNA isolation. J Am Soc Cytopathol. 2017 Jan - Feb; 6 (1):24-27 Epub 2016 Aug 18
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  16. Willmore-Payne C, Damjanovich-Colmenares K, Pasi AV, Werner TL, Gulbahce HE, Downs-Kelly E, Geiersbach KB. Inconsistent Results With Different Secondary Reflex Assays for Resolving HER2 Status. Am J Clin Pathol. 2016 Nov 1; 146 (5):618-626
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  17. Geiersbach KB, Willmore-Payne C, Pasi AV, Paxton CN, Werner TL, Xu X, Wittwer CT, Gulbahce HE, Downs-Kelly E. Genomic Copy Number Analysis of HER2-Equivocal Breast Cancers. Am J Clin Pathol. 2016 Oct; 146 (4):439-47 Epub 2016 Sept 10
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  18. Lynam-Lennon N, Bibby BA, Mongan AM, Marignol L, Paxton CN, Geiersbach K, Bronner MP, O'Sullivan J, Reynolds J, Maher SG. Low miR-187 expression promotes resistance to chemoradiation therapy in vitro and correlates with treatment failure in patients with esophageal adenocarcinoma. Mol Med. 2016 May 23; 22:
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  19. Geiersbach K, Adey N, Welker N, Elsberry D, Malmberg E, Edwards S, Downs-Kelly E, Salama M, Bronner M. Digitally guided microdissection aids somatic mutation detection in difficult to dissect tumors. Cancer Genet. 2016 Jan-Feb; 209: (1-2)42-9.
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  20. Geiersbach K, Adey N, Welker N, Elsberry D, Malmberg EM, Downs-Kelly E, Salama ME, Bronner MP. Milling Microdissection Enriches Tumor Content for Molecular Testing Without Sacrificing Nucleic Acid Yield. Cancer Genet.2016;209:(1-2):42-9.
  21. Zhou L, Palais RA, Paxton CN, Geiersbach KB, Wittwer CT. Copy number assessment by competitive PCR with limiting deoxynucleotide triphosphates and high-resolution melting. Clin Chem. 2015 May; 61: (5)724-33.
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  22. Romero ST, Geiersbach KB, Paxton CN, Rose NC, Schisterman EF, Branch DW, Silver RM. Differentiation of genetic abnormalities in early pregnancy loss. Ultrasound Obstet Gynecol. 2015 Jan; 45: (1)89-94.
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  23. Garrido-Laguna I, Tometich D, Hu N, Ying J, Geiersbach K, Whisenant J, Wang K, Ross JS, Sharma S. N of 1 case reports of exceptional responders accrued from pancreatic cancer patients enrolled in first-in-man studies from 2002 through 2012. Oncoscience. 2015; 2: (3)285-93.
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  24. Leoni C, Stevenson DA, Geiersbach KB, Paxton CN, Krock BL, Mao R, Rope AF. Neural tube defects and atypical deletion on 22q11.2. Am J Med Genet A. 2014 Nov; 164A: (11)2701-6.
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  25. Geiersbach KB, Gardiner AE, Wilson A, Shetty S, Bruyere H, Zabawski J, Saxe DF, Gaulin R, Williamson C, Van Dyke DL. Subjectivity in chromosome band-level estimation: a multicenter study. Genet Med. 2014 Feb; 16: (2)170-5.
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  26. Jarboe EA, Hirschowitz SL, Geiersbach KB, Wallander ML, Tripp SR, Layfield LJ. Juvenile granulosa cell tumors: immunoreactivity for CD99 and Fli-1 and EWSR1 translocation status: a study of 11 cases. Int J Gynecol Pathol. 2014 Jan; 33: (1)11-5.
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  27. Wilkerson MD, Schallheim JM, Hayes DN, Roberts PJ, Bastien RR, Mullins M, Yin X, Miller CR, Thorne LB, Geiersbach KB, Muldrew KL, Funkhouser WK, Fan C, Hayward MC, Bayer S, Perou CM, Bernard PS. Prediction of lung cancer histological types by RT-qPCR gene expression in FFPE specimens. J Mol Diagn. 2013 Jul; 15: (4)485-97.
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  28. Furtado LV, Jama MA, Paxton CN, Wilson AA, Gardiner AE, Lyon E, Geiersbach KB. Aneuploidy detection in paraffin embedded tissue from products of conception by mini-STR genotyping. Fetal Pediatr Pathol. 2013 Apr; 32: (2)133-50.
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  29. Paxton CN, Brothman AR, Geiersbach KB. Rapid aneusomy detection in products of conception using the KaryoLite BACs-on-Beads assay. Prenat Diagn. 2013 Jan; 33: (1)25-31.
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  30. Furtado LV, Paxton CN, Jama MA, Tripp SR, Wilson AR, Lyon E, Jarboe EA, Thaker HM, Geiersbach KB. Diagnostic utility of microsatellite genotyping for molar pregnancy testing. Arch Pathol Lab Med. 2013 Jan; 137: (1)55-63.
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  31. Adey N, Emery D, Bosh D, Callahan S, Schreiner J, Chen Y, Greig A, Geiersbach K, Parry R. A mill based instrument and software system for dissecting slide-mounted tissue that provides digital guidance and documentation. BMC Clin Pathol. 2013; 13: (1)29.
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  32. Wallander ML, Geiersbach KB, Tripp SR, Layfield LJ. Comparison of reverse transcription-polymerase chain reaction, immunohistochemistry, and fluorescence in situ hybridization methodologies for detection of echinoderm microtubule-associated proteinlike 4-anaplastic lymphoma kinase fusion-positive non-small cell lung carcinoma: implications for optimal clinical testing. Arch Pathol Lab Med. 2012 Jul; 136: (7)796-803.
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  33. Geiersbach KB, Jarboe EA, Jahromi MS, Baker CL, Paxton CN, Tripp SR, Schiffman JD. FOXL2 mutation and large-scale genomic imbalances in adult granulosa cell tumors of the ovary. Cancer Genet. 2011 Nov; 204: (11)596-602.
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  34. Geiersbach KB, Samowitz WS. Microsatellite instability and colorectal cancer. Arch Pathol Lab Med. 2011 Oct; 135: (10)1269-77.
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  35. Geiersbach K, Rector LS, Sederberg M, Hooker A, Randall RL, Schiffman JD, South ST. Unknown partner for USP6 and unusual SS18 rearrangement detected by fluorescence in situ hybridization in a solid aneurysmal bone cyst. Cancer Genet. 2011 Apr; 204: (4)195-202.
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  36. Dames S, Durtschi J, Geiersbach K, Stephens J, Voelkerding KV. Comparison of the Illumina Genome Analyzer and Roche 454 GS FLX for resequencing of hypertrophic cardiomyopathy-associated genes. J Biomol Tech. 2010 Jul; 21: (2)73-80.
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