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Proton therapy

Clinical trials

Below are current clinical trials.


8 studies in Proton therapy
(open studies only).

Filter this list of studies by location, status and more.

  1. A Registry for Children Treated with Proton Radiation Therapy

    Rochester, Minn.

    The purpose of the Pediatric Proton Consortium Registry (PPCR) is to enroll children who have been treated with proton radiation in the United States in order to describe the population that currently receives protons and better evaluate its benefits over other therapies. The data collected from this study will help facilitate research on proton beam radiation therapy and allow for collaborative research. The PPCR will collect demographic and clinical data which many centers that deliver proton radiation therapy already collect in routine operations.

  2. A Study to Compare the Toxic Effects and Disease Outcomes of Intensity-Modulated Proton Beam Therapy versus Intensity-Modulated Photon Therapy for the Treatment of Mouth and Throat Cancers

    Rochester, Minn.

    The purpose of this study is to compare the toxic side effects and disease outcomes of intensity modulated photon therapy versus intensity modulated proton therapy. Participants may also receive chemotherapy along with radiation therapy.

     

  3. A Study to Evaluate the Safety and Effectiveness of Hypofractionation Proton Beam Therapy in Patients who have Clinically Localized, High Risk or Unfavorable Intermediate Risk Prostate Cancer

    Scottsdale/Phoenix, Ariz., Rochester, Minn.

    The purpose of this study is to evaluate the safety and effectiveness of a moderate hypofractionation regimen of proton beam therapy with same time treatment of the prostate, seminal vesicles, and the regional pelvic nodes  for patients who have clinically localized, high risk or unfavorable intermediate risk prostate cancer.

  4. Cardiac Function in Patients Undergoing Proton Beam or Photon Radiotherapy

    Rochester, Minn.

    The purpose of this study is to determine whether conventional  or new (2D- speckle tracking echocardiography) parameters of left and right ventricular function are impaired during and at the end of proton beam or photon radiotherapy.

  5. A Trial of 15 Fraction vs 25 Fraction Pencil Beam Scanning Proton Radiotherapy After Mastectomy in Patients Requiring Regional Nodal Irradiation

    Scottsdale/Phoenix, Ariz., Rochester, Minn.

    The purpose of this trial is to determine the safety of 15 fraction vs 25 fraction pencil beam scanning proton radiotherapy after mastectomy in patients requiring regional nodal irradiation. Proton therapy is recognized as a standard option for the delivery of radiotherapy for breast cancer.

  6. Proton Therapy vs. IMRT for Low or Intermediate Risk Prostate Cancer

    Rochester, Minn.

    We are studying whether men being treated for prostate cancer have the same amount of side effects from either one of two different external radiation treatments: IMRT or PBT. With IMRT, a number of x-ray beams are used to shape the radiation to the prostate. PBT is another type of external radiation treatment for prostate cancer that is used in a few centers in the United States. Protons are tiny particles with positive charge that can be controlled to travel a certain distance and stop. PBT is precise like IMRT, but it uses proton beams instead of x-ray beams. IMRT and PBT aim to deliver most of the radiation to the prostate cancer while sparing surrounding tissues. Both IMRT and PBT have been used in the treatment of prostate cancer and are thought to be equally effective at curing prostate cancer. However, both treatments have also been shown to cause the potential side effects of radiation, including bowel, urinary and erectile problems. It is possible that side effect rates with PBT will be lower, the same, or even higher than with IMRT, but this has not been studied well to date. Though both of these radiation therapies have been used in the past to treat prostate cancer, there has never been a study that compares the effects of these two therapies to see which one has less side effects. In this research study, we are comparing IMRT to PBT to determine which therapy best minimizes the side effects of treatment.

  7. A Study of Using Proton Beam Therapy Which Spares Mucosal Tissue Following the Removal of Oropharyngeal Tumors

    Scottsdale/Phoenix, Ariz., Rochester, Minn.

    The purpose of this study is to evaluate the clinical outcomes of lower intensity (mucosal tissue sparing) proton beam therapy after the surgical removal of oropharyngeal tumors in cancer patients who have a favorable level of risk.

  8. A Study of Proton Radiation Divided into Fewer Doses for Low Risk Prostate Cancer

    Scottsdale/Phoenix, Ariz., Rochester, Minn.

    The purpose of this study is to compare the effects (good and bad) on patients with prostate cancer by comparing the standard dose of radiation therapy (44 treatments over 8½-9 weeks) with a higher daily dose of radiation (5 treatments over 1-2 weeks) to see if the effects of the treatments are similar or better.

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Departments & specialtiesIn-Depth
April 09, 2016
References
  1. Brada M, et al. Current clinical evidence for proton therapy. Cancer Journal. 2009;15:319.
  2. Ahmad S, et al. Advances in radiotherapy. BMJ. 2012;345:e7765.
  3. Flanz J, et al. Technology for proton therapy. Cancer Journal. 2009;15:292.
  4. Devicienti S, et al. Patient positioning in the proton radiotherapy era. Journal of Experimental & Clinical Cancer Research. 2010;29:47.
  5. Proton therapy. RadiologyInfo.org. http://www.radiologyinfo.org/en/info.cfm?pg=protonthera. Accessed Jan. 21, 2016.
  6. Found 180 open studies with search of: proton therapy AND cancer. ClinicalTrials.gov. http://www.clinicaltrials.gov/ct2/results?term=proton+therapy+AND+cancer. Accessed Jan. 21, 2016.
  7. Foote RL, et al. The clinical case for proton beam therapy. Radiation Oncology. 2012;7:174.
  8. Wang D. A critical appraisal of the clinical utility of proton therapy in oncology. Medical Devices: Evidence and Research. 2015;8:439.
  9. Schulz-Ertner D. The clinical experience with particle therapy in adults. Cancer Journal. 2009;15:306.
  10. Allen AM, et al. An evidence based review of proton beam therapy: The report of ASTRO's emerging technology committee. Radiotherapy and Oncology. 2012;103:8.
  11. McMullen KP, et al. Practical aspects of pediatric proton radiation therapy. The Cancer Journal. 2014;20:393.
  12. Plastaras JP, et al. Special cases for proton beam radiotherapy: Re-irradiation, lymphoma, and breast cancer. Seminars in Oncology. 2014;41:807.
  13. Chen AB. Comparative effectiveness research in radiation oncology: Assessing technology. Seminars in Radiation Oncology. 2014;24:25.
  14. Foote RL. Personal correspondence. Mayo Clinic, Rochester, Minn. Jan. 25, 2016.
  15. Foote RL. Personal correspondence. Mayo Clinic, Rochester, Minn. March 1, 2016.

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Proton therapy

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