Quality CareFind out why Mayo Clinic is the right place for your health care. Make an appointment.
Meet the StaffFind a directory of doctors and departments at all Mayo Clinic campuses. Visit now.
Research and Clinical TrialsSee how Mayo Clinic research and clinical trials advance the science of medicine and improve patient care. Explore now.
Visit Our SchoolsEducators at Mayo Clinic train tomorrow’s leaders to deliver compassionate, high-value, safe patient care. Choose a degree.
Professional ServicesExplore Mayo Clinic’s many resources and see jobs available for medical professionals. Get updates.
Give to Mayo ClinicHelp set a new world standard in care for people everywhere. Give now.
Mayo Clinic offers appointments in Arizona, Florida and Minnesota and at Mayo Clinic Health System locations.
Subscribe to Housecall
Our general interest e-newsletter keeps you up to date on a wide variety of health topics.
Phosphatidylserine (fos-fuh-tie-dul-SER-een) is a dietary supplement that has received some interest as a potential treatment for Alzheimer's disease and other memory problems. Several studies with phosphatidylserine indicate improved cognitive abilities and behaviors. However, improvements lasted only a few months and were seen in people with the least severe symptoms.
Initially, phosphatidylserine supplements were derived from the brain cells of cows. But because of concerns about mad cow disease, most manufacturers now produce the supplements from soy or cabbage derivatives. Preliminary studies have shown that plant-based phosphatidylserine supplements may also offer benefits, but more research is needed. However, no modern studies have continued to focus on phosphatidylserine, suggesting its limited effect.
Keep in mind that the Food and Drug Administration doesn't require manufacturers to provide evidence of the potential risks and benefits of phosphatidylserine — or of any supplement. Consult your doctor before starting any dietary supplement.
Glenn Smith, Ph.D.
Mayo Clinic does not endorse companies or products. Advertising revenue supports our not-for-profit mission.
Check out these best-sellers and special offers on books and newsletters from Mayo Clinic.
Mayo Clinic is a not-for-profit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not endorse any of the third party products and services advertised.
A single copy of these materials may be reprinted for noncommercial personal use only. "Mayo," "Mayo Clinic," "MayoClinic.org," "Mayo Clinic Healthy Living," and the triple-shield Mayo Clinic logo are trademarks of Mayo Foundation for Medical Education and Research.