There's no specific test today that confirms you have Alzheimer's disease. Your doctor will make a judgment about whether Alzheimer's is the most likely cause of your symptoms based on the information you provide and results of various tests that can help clarify the diagnosis.
Doctors can nearly always determine whether you have dementia, and they can often identify whether your dementia is due to Alzheimer's disease. Alzheimer's disease can be diagnosed with complete accuracy only after death, when microscopic examination of the brain reveals the characteristic plaques and tangles.
To help distinguish Alzheimer's disease from other causes of memory loss, doctors now typically rely on the following types of tests.
Physical and neurological exam
Your doctor will perform a physical exam, and is likely to check your overall neurological health by testing your:
- Muscle tone and strength
- Ability to get up from a chair and walk across the room
- Sense of sight and hearing
Blood tests may help your doctor rule out other potential causes of memory loss and confusion, such as thyroid disorders or vitamin deficiencies.
Mental status testing
Your doctor may conduct a brief mental status test to assess your memory and other thinking skills. Short forms of mental status testing can be done in about 10 minutes.
Your doctor may recommend a more extensive assessment of your thinking and memory. Longer forms of neuropsychological testing, which can take several hours to complete, may provide additional details about your mental function compared with others' of a similar age and education level.
This type of testing may be especially helpful if your doctor thinks you may have a very early stage of Alzheimer's disease or another dementia. These tests may also help identify patterns of change associated with different types of dementia and can help doctors estimate your ability to safely manage important activities, such as financial and medical decision-making.
Images of the brain are now used chiefly to pinpoint visible abnormalities related to conditions other than Alzheimer's disease — such as strokes, trauma or tumors — that may cause cognitive change. New imaging applications — currently used primarily in major medical centers or in clinical trials — may enable doctors to detect specific brain changes caused by Alzheimer's.
Brain-imaging technologies include:
Magnetic resonance imaging (MRI). An MRI uses radio waves and a strong magnetic field to produce detailed images of your brain. You lie on a narrow table that slides into a tube-shaped MRI machine, which makes loud banging noises while it produces images. MRIs are painless, but some people feel claustrophobic inside the machine and are disturbed by the noise.
MRIs are used to rule out other conditions that may account for or be adding to cognitive symptoms. In addition, they may be used to assess whether shrinkage in brain regions implicated in Alzheimer's disease has occurred.
- Computerized tomography (CT). For a CT scan, you'll lie on a narrow table that slides into a small chamber. X-rays pass through your body from various angles, and a computer uses this information to create cross-sectional images (slices) of your brain. It's currently used chiefly to rule out tumors, strokes and head injuries.
Positron emission tomography (PET). During a PET scan, you'll be injected in a vein with a low-level radioactive tracer. You'll lie on a table while an overhead scanner tracks the tracer's flow through your brain.
The tracer may be a special form of glucose (sugar) that shows overall activity in various brain regions. This can show which parts of your brain aren't functioning well. New PET techniques may be able to detect your brain level of plaques and tangles, the two hallmark abnormalities linked to Alzheimer's.
Future diagnostic tests
Researchers are working with doctors to develop new diagnostic tools to help definitively diagnose Alzheimer's. Another important goal is to detect the disease before it causes the symptoms targeted by current diagnostic techniques — at the stage when Alzheimer's may be most treatable as new drugs are discovered. This stage is called preclinical Alzheimer's disease.
New tools under investigation include:
Jun. 17, 2014
- Additional approaches to brain imaging
- More-sensitive tests of mental abilities
- Measurement of key proteins or protein patterns in blood or spinal fluid (biomarkers)
- Goldman L, et al. Goldman's Cecil Medicine. 24th ed. Philadelphia, Pa.: Saunders Elsevier; 2012. http://www.clinicalkey.com. Accessed April 8, 2014.
- Alzheimer's disease fact sheet. National Institute on Aging. http://www.nia.nih.gov/alzheimers/publication/alzheimers-disease-fact-sheet. Accessed April 8, 2014.
- Longo DL, et al. Harrison's Online. 18th ed. New York, N.Y.: The McGraw-Hill Companies; 2012. http://www.accessmedicine.com/resourceTOC.aspx?resourceID=4. Accessed April 8, 2014.
- Halter JB, et al. Hazzard's Geriatric Medicine and Gerontology. 6th ed. New York, N.Y.: The McGraw-Hill Companies; 2009. http://www.accessmedicine.com/resourceTOC.aspx?resourceID=540. Accessed April 8, 2014.
- Leal SL, et al. Perturbations of neural circuitry in aging, mild cognitive impairment, and Alzheimer's disease. Ageing Research Reviews. 2013;12:823.
- Wright CB. Etiology, clinical manifestations, and diagnosis of vascular dementia. http://www.uptodate.com/home. Accessed April 8, 2014.
- Papadakis MA, ed., et al. Current Medical Diagnosis & Treatment 2014. 53rd ed. New York, N.Y.: The McGraw-Hill Companies; 2014. http://www.accessmedicine.com/resourceTOC.aspx?resourceID=1. Accessed April 8, 2014.
- Grabowski TJ. Clinical manifestations and diagnosis of Alzheimer’s disease. http://www.uptodate.com/home. Accessed April 8, 2014.
- Caring for a person with Alzheimer's disease. National Institute on Aging. http://www.nia.nih.gov/alzheimers/publication/caring-person-alzheimers-disease/about-guide. Accessed April 8, 2014.
- Alternative treatments. Alzheimer's Association. http://www.alz.org/alzheimers_disease_alternative_treatments.asp. Accessed April 8, 2014.
- Alzheimer's disease at a glance. National Center for Complementary and Alternative Medicine. http://nccam.nih.gov/health/alzheimer/ataglance. Accessed April 8, 2014.
- Smith GE (expert opinion). Mayo Clinic, Rochester, Minn. April 19, 2014.
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