Skin changes are the only signs of acanthosis nigricans. You'll notice dark, thickened, velvety skin in body folds and creases — typically in your armpits, groin and back of the neck. The skin changes usually appear slowly. The affected skin may also have an odor or itch.
When to see a doctor
Consult your doctor if you notice changes in your skin — especially if the changes appear suddenly. You may have an underlying condition that needs treatment.
June 02, 2015
- AskMayoExpert. Polycystic ovary syndrome. Rochester, Minn.: Mayo Foundation for Medical Education and Research; 2014.
- Habif TP. Cutaneous manifestations of internal disease. In: Clinical Dermatology: A Color Guide to Diagnosis and Therapy. 5th ed. Edinburgh, U.K.; New York, N.Y.: Mosby Elsevier; 2010. http://www.clinicalkey.com. Accessed March 25, 2015.
- Niacin and niacinamide (vitamin B3). Natural Medicines Comprehensive Database. http://naturaldatabase.therapeuticresearch.com. Accessed March 27, 2015.
- Gibson LE. Acanthosis nigricans. Mayo Clinic Proceedings. 2004;79:1571.
- Goldsmith LA, et al., eds. Diabetes Mellitus and other endocrine diseases. In: Fitzpatrick's Dermatology in General Medicine. 8th ed. New York, N.Y.: The McGraw-Hill Companies; 2012. http://www.accessmedicine.com. Accessed March 25, 2015.
- Goldsmith LA, et al., eds. Cutaneous manifestations of internal malignant disease. In: Fitzpatrick's Dermatology in General Medicine. 8th ed. New York, N.Y.: The McGraw-Hill Companies; 2012. http://www.accessmedicine.com. Accessed March 25, 2015.
- Braunstein I. Acanthosis nigricans. http://www.uptodate.com/home. Accessed March 25, 2015.