概述

未分化多形性肉瘤(UPS)一种罕见癌症,最常起源于身体的软组织中。软组织用于连接、支撑和围绕其他身体结构。

UPS 通常出现在手臂或腿部。较为少见的情况下,它也会出现在腹部后方的区域(腹膜后腔)。

未分化多形性肉瘤的名称源自癌细胞在显微镜下显示的形态。未分化意味着细胞看上去不像其从中发育的身体组织。这种癌症被称为多形性是因为细胞会生长成多种形状和大小。

UPS 的治疗方法取决于癌症的位置,但是往往涉及手术、放疗和药物治疗。

UPS 过去曾称为恶性纤维组织细胞瘤。

症状

未分化多形性肉瘤的症状取决于肿瘤发生的部位。最常发生于手臂和腿部,但可发生于身体任何部位。

体征和症状可能包括:

  • 肿块生长或局部肿胀
  • 如果长得很大,可有疼痛、刺痛和麻木
  • 如果发生在手臂或腿部,患肢的手或脚可能会肿胀。
  • 如发生于腹部,可能造成疼痛、食欲不振和便秘
  • 发热
  • 体重减轻

何时就诊

如果您对持续出现的体征或症状感到担心,请预约就诊。

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病因

目前尚不清楚导致未分化多形性肉瘤的原因。

医生知道这种癌症始于细胞中的 DNA 变化。细胞的 DNA 包含指示细胞工作的指令。上述 DNA 变化会指示细胞快速增殖,形成大量异常细胞(肿瘤)。癌细胞会侵入和破坏附近的健康组织。随着时间的推移,癌细胞可脱离原位并扩散(转移)至身体其他部位,例如肺部和骨骼。

风险因素

可能增加患未分化多形性肉瘤风险的因素包括:

  • 年龄较大。虽然任何年龄段的人都有可能患该癌症,但其往往多见于 50 岁以上的成人。
  • 曾接受过放射疗法。极少数情况下,曾接受过放射疗法的身体部位可能出现这种癌症。

大多数患有未分化多形性肉瘤的人并没有任何已知的风险因素,而许多存在风险因素的人群却从未患此癌症。

在 Mayo Clinic 治疗

March 20, 2020
  1. Goldblum JR, et al. Undifferentiated pleomorphic sarcoma. In: Enzinger and Weiss's Soft Tissue Tumors. 7th ed. Elsevier; 2020. https://www.clinicalkey.com. Accessed Jan. 23, 2020.
  2. Azar FM, et al. Soft-tissue tumors. In: Campbell's Operative Orthopaedics. 13th ed. Elsevier; 2017. https://www.clinicalkey.com. Accessed Jan. 23, 2020.
  3. Soft tissue sarcoma. National Comprehensive Cancer Network. https://www.nccn.org/professionals/physician_gls/default.aspx. Accessed Jan. 23, 2020.
  4. Ryan CW, et al. Clinical presentation, histopathology, diagnostic evaluation and staging of soft tissue sarcoma. https://www.uptodate.com/contents/search. Accessed Jan. 24, 2020.
  5. Widemann BC, et al. Biology and management of undifferentiated pleomorphic sarcoma, myxofibrosarcoma and malignant peripheral nerve sheath tumors: State of the art and perspectives. Journal of Clinical Oncology. 2017; doi:10.1200/JCO.2017.75.3467.
  6. Roeder F, et al. Intraoperative radiation therapy in soft-tissue sarcoma. Radiation Oncology. 2017; doi:10.1186/s13014-016-0751-2.
  7. Deng GE, et al. Evidence-based clinical practice guidelines for integrative oncology: Complementary therapies and botanicals. Journal of the Society for Integrative Oncology. 2009; doi:10.2310/7200.2009.0019.
  8. NCI dictionary of cancer terms. National Cancer Institute. https://www.cancer.gov/publications/dictionaries/cancer-terms. Accessed Jan. 24, 2020.
  9. Warner KJ. Allscripts EPSi. Mayo Clinic. July 18, 2019.