MELD (model for end-stage liver disease) score

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Departamentos y especialidades

Mayo Clinic tiene uno de los consultorios médicos más grandes y experimentados en los Estados Unidos, con campus en Arizona, Florida y Minnesota. El personal, que está capacitado en muchas especialidades, trabaja en conjunto para garantizar la atención de calidad y la recuperación exitosa.

Departamentos con pericia relacionada

Investigación

In addition to inventing technology to accurately diagnose cirrhosis, Mayo Clinic researchers developed the model for end-stage liver disease (MELD) score. The MELD scoring system is now used nationwide to assess people's disease progression and allocate organs for transplant.

Researchers in the Transplant Research Center are actively engaged in studying improved surgical procedures and developing new antirejection medicines, treatments and techniques to make transplants safer and available to more people. Mayo Clinic scientists, doctors and surgeons develop liver transplant insights and innovations that make transplants safer and available for more people. They are actively involved in conducting laboratory studies, clinical trials and other research on every aspect of conditions related to liver transplants.

Publications

See a list of publications about the MELD score by Mayo Clinic doctors on PubMed, a service of the National Library of Medicine.

Perfiles de la investigación

MELD (model for end-stage liver disease) score - atención en Mayo Clinic

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SobreAtención médica en Mayo Clinic
Oct. 28, 2025
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  1. Guo G, et al. The development and appraisal of MELD 3.0 in liver diseases: Good things never come easy. Journal of Clinical Translational Hepatology. 2024; doi:10.14218/JCTH.2020.00303.
  2. Kim WR, et al. MELD 3.0: The model for end-stage liver disease updated for the modern era. Gastroenterology. 2021; doi:10.1053/j.gastro.2021.08.050.
  3. A guide to taking warfarin. American Heart Association. https://www.heart.org/en/health-topics/arrhythmia/prevention--treatment-of-arrhythmia/a-patients-guide-to-taking-warfarin. Accessed July 25, 2025.
  4. Wang Y, et al. Increased INR values predict accelerating deterioration and high short-term mortality among patients hospitalized with cirrhosis or advanced fibrosis. Frontiers. 2021; doi:10.3389/fmed.2021.762291.
  5. Creatinine. National Kidney Foundation. https://www.kidney.org/kidney-topics/creatinine. Accessed July 28, 2025.
  6. Casciola R, et al. Creatine supplementation to improve sarcopenia in chronic liver disease: Facts and perspectives. Nutrients. 2023; doi:10.3390/nu15040863.
  7. Guerra Ruiz AR, et al. Measurement and clinical usefulness of bilirubin in liver disease. Advances in Laboratory Medicine. 2021; doi:10.1515/almed-2021-0047.
  8. Lenci I, et at. Natremia and liver transplantation: The right amount of salt for a good recipe. World Journal of Hepatology. 2020; doi:10.4254/wjh.v12.i11.919.
  9. Edema (swelling) and cancer treatment. National Cancer Institute. https://www.cancer.gov/about-cancer/treatment/side-effects/edema. Accessed July 28, 2025.
  10. Nouraie M, et al. Serum albumin is independently associated with higher mortality in adult sickle cell patients: Results of three independent cohorts. PLOS One. 2020; doi:10.1371/journal.pone.0237543.
  11. Dale E, et al. Inconsistent values and algorithmic fairness: a review of organ allocation priority systems in the United States. BMC Medical Ethics. 2024; doi:10.1186/s12910-024-011.
  12. Becchetti C, et al. Sex-based disparities in liver transplantation: Evidence from a nationwide Italian cohort. JHEP Reports. 2025; doi:10.1016/j.jhepr.2025.101387.
  13. Bambha K, et al. Model for end-stage liver disease (MELD). https://www.uptodate.com/contents/search. Accessed Aug. 7, 2025.
  14. Bednar R, et al. Low back pain in patients hospitalised with liver cirrhosis — A retrospective study. BMC Musculoskeletal Disorders. 2023; doi:10.1186/s12891-023-06424-8.
  15. Forna L, et al. Pediatric perspectives on liver cirrhosis: Unravelling clinical patterns and therapeutic challenges. Journal of Clinical Medicine. 2024; doi:10.3390/jcm13144275.
  16. Yun G, et al. Evaluation and management of hypernatremia in adults: clinical perspectives. Korean Journal of Internal Medicine. 2022; doi:10.3904/kjim.2022.346.
  17. Gines P, et al. Liver cirrhosis. The Lancet. 2021; doi:10.1016/S0140-6736(21)01374-X.
  18. Alcohol-associated liver disease. American Liver Foundation. https://liverfoundation.org/liver-diseases/alcohol-associated-liver-disease/#1507302760988-870375fd-f7al. Accessed Aug. 7, 2025.
  19. Questions and answers about liver allocation. Organ Procurement and Transplantation Network. https://optn.transplant.hrsa.gov/patients/by-organ/liver/questions-and-answers-about-liver-allocation. Accessed Aug. 7, 2025.
  20. Puri P, et al. Liver transplantation: Contraindication and ineligibility. Journal of Clinical and Experimental Hepatology. 2023; doi:10.1016/j.jceh.2023.04.005.
  21. Luo Z, et al. MELD as a metric for survival benefit of liver transplantation. American Journal of Transplantation. 2018; doi:10.1111/ajt.14660.
  22. Ge J, et al. "Beyond MELD" — Emerging strategies and technologies for improving mortality prediction, organ allocation and outcomes in liver transplantation. Journal of Hepatology. 2022; doi:10.1016/j.jhep.2022.03.003.
  23. Ni K, et al. MELD score reflects the mood, sleep, and daily living ability in liver transplantation candidates: A descriptive study. Annals of Transplantation. 2020; doi:10.12659/AOT.926857.
  24. Kiene SM, et al. Efficacy of an enhanced linkage to HIV care intervention at improving linkage to HIV care and achieving viral suppression following home-based HIV testing in rural Uganda: Study protocol for the Ekkubo/PATH cluster randomized controlled trial. BMC Infectious Diseases. 2017; doi:10.1186/s12879-017-2537-z.
  25. Bendersky VA, et al. The evolving role of liver transplantation for metastatic colorectal cancer: current perspectives and future directions. Frontiers in Surgery. 2025; doi:10.3389/fsurg.2025.1608467.
  26. Cameron JL, et al. Liver transplantation. In: Current Surgical Therapy. 14th ed. Elsevier; 2023. https://www.clinicalkey.com. Accessed Aug. 19, 2025.
  27. Goldstein NE, et al. What are the causes and complications of chronic liver disease and what is the evidence for palliative care delivery to those affected by it? In: Evidence-Based Practice of Palliative Medicine. 2nd ed. Elsevier; 2023. https://www.clinicalkey.com. Accessed Aug. 20, 2025.
  28. MELD calculator. Mayo Clinic. https://www.mayoclinic.org/medical-professionals/transplant-medicine/calculators/meld-model/itt-20434705. Accessed Aug. 20, 2025.
  29. MELD score and 90-day mortality rate for alcoholic hepatitis. Mayo Clinic. https://www.mayoclinic.org/medical-professionals/transplant-medicine/calculators/meld-score-and-90-day-mortality-rate-for-alcoholic-hepatitis/itt-20434719. Accessed Aug. 20, 2025.
  30. Learn about MELD. Organ Procurement and Transplantation Network. https://optn.transplant.hrsa.gov/data/allocation-calculators/meld-calculator/learn-about-meld. Accessed Aug. 20, 2025.
  31. MELD scores and mortality. Merck Manual Professional Version. https://www.merckmanuals.com/professional/multimedia/table/meld-scores-and-mortality. Accessed Aug. 20, 2025.
  32. Liver transplant. Mayo Clinic. https://www.mayoclinic.org/tests-procedures/liver-transplant/about/pac-20384842. Accessed Sept. 25, 2025.
  33. Cirrhosis. Mayo Clinic. https://www.mayoclinic.org/diseases-conditions/cirrhosis/symptoms-causes/syc-20351487. Accessed Sept. 25, 2025.

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MELD (model for end-stage liver disease) score