Before Using

Drug information provided by: Merative, Micromedex®


Tell your doctor if you have ever had any unusual or allergic reaction to medicines in this group or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.


Tetracyclines may cause permanent discoloration of teeth and slow down the growth of bones. These medicines should not be given to children 8 years of age and younger unless directed by the child's doctor.


Many medicines have not been studied specifically in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults or if they cause different side effects or problems in older people. There is no specific information comparing use of tetracyclines in the elderly with use in other age groups.


Use is not recommended during the last half of pregnancy. If tetracyclines are taken during that time, they may cause the unborn infant's teeth to become discolored and may slow down the growth of the infant's teeth and bones. In addition, liver problems may occur in pregnant women, especially those receiving high doses by injection into a vein.


Use is not recommended since tetracyclines pass into breast milk. They may cause the nursing baby's teeth to become discolored and may slow down the growth of the baby's teeth and bones. They may also increase the sensitivity of nursing babies' skin to sunlight and cause fungus infections of the mouth and vagina. In addition, minocycline may cause dizziness, light-headedness, or unsteadiness in nursing babies.

Drug Interactions

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking any of these medicines, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using medicines in this class with any of the following medicines is not recommended. Your doctor may decide not to treat you with a medication in this class or change some of the other medicines you take.

  • Acitretin
  • Methoxyflurane

Using medicines in this class with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Abametapir
  • Acenocoumarol
  • Amoxicillin
  • Ampicillin
  • Apixaban
  • Ardeparin
  • Argatroban
  • Ascorbic Acid
  • Atazanavir
  • Bacampicillin
  • Betrixaban
  • Bexarotene
  • Bivalirudin
  • Carbamazepine
  • Certoparin
  • Cholera Vaccine, Live
  • Clarithromycin
  • Cloxacillin
  • Dabigatran Etexilate
  • Dalteparin
  • Danaparoid
  • Desirudin
  • Desogestrel
  • Dicloxacillin
  • Dienogest
  • Digoxin
  • Drospirenone
  • Edoxaban
  • Enoxaparin
  • Enzalutamide
  • Estradiol
  • Ethinyl Estradiol
  • Ethynodiol
  • Etretinate
  • Fedratinib
  • Fexinidazole
  • Fondaparinux
  • Fosphenytoin
  • Gestodene
  • Heparin
  • Isotretinoin
  • Itraconazole
  • Lepirudin
  • Levoketoconazole
  • Levonorgestrel
  • Lumacaftor
  • Magnesium Sulfate
  • Mavacamten
  • Mestranol
  • Methicillin
  • Methotrexate
  • Methoxyflurane
  • Mitotane
  • Nafcillin
  • Nomegestrol
  • Norethindrone
  • Norgestimate
  • Norgestrel
  • Omaveloxolone
  • Oxacillin
  • Palovarotene
  • Parnaparin
  • Penicillin G
  • Penicillin G Benzathine
  • Penicillin G Procaine
  • Penicillin V
  • Phenindione
  • Phenobarbital
  • Phenprocoumon
  • Phenytoin
  • Piperacillin
  • Pivampicillin
  • Porfimer
  • Primidone
  • Protein C
  • Quizartinib
  • Repotrectinib
  • Reviparin
  • Rifampin
  • Rivaroxaban
  • St John's Wort
  • Sultamicillin
  • Temocillin
  • Tinzaparin
  • Tretinoin
  • Warfarin

Other Interactions

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of medicines in this class. Make sure you tell your doctor if you have any other medical problems, especially:

  • Diabetes insipidus (water diabetes)—Demeclocycline may make the condition worse.
  • Kidney disease (does not apply to doxycycline or minocycline)—Patients with kidney disease may have an increased chance of side effects.
  • Liver disease—Patients with liver disease may have an increased chance of side effects if they use doxycycline or minocycline.