Medicina cardiovascular

A continuación, se enumeran los ensayos clínicos actuales.

Filtra esta lista de estudios por sede, estatus, etc.

1. Prevalence of Transthyretin Cardiac Amyloidosis in Clinically Significant Aortic Stenosis

   Rochester, Minn.

   The purpose of this study is to determine the prevalence of TTR-CA in a community-based cohort of moderate and severe aortic stenosis patients using 99mTc-PYP single-photon positive emission computed tomography with computed tomography (SPECT/CT).

2. A Study to Evaluate Autologous Bone Marrow Mononuclear Cells Using the CardiAMP™ Cell Therapy in Patients With Post Myocardial Infarction Heart Failure

   Scottsdale/Phoenix, Ariz.

   The purpose of this study is to compare treatment with the CardiAMP cell therapy to a sham treatment. A roll-in phase with a maximum of 10 subjects will precede the randomised phase.

3. A Study to Evaluate MYK-491 to Treat Patients with Primary Dilated Cardiomyopathy (DCM) Due to Genetic Variants

   Rochester, Minn.

   The purpose of this study is to establish safety and preliminary effectiveness of treatment with MYK-491 in patients with primary dilated cardiomyopathy (DCM) due to MYH7 or TTN variants .

4. Echocardiographic Measures of Pulmonary Vascular Distensibility and Effects on Lung Diffusing Capacity

   Rochester, Minn.

   The purpose of this study is to determine if the change in pulmonary vascular compliance with positional changes (upright, supine, and Trendelenburg position) is different in younger versus older individuals.

5. A Study to Evaluate Potential Myocardial Injury Following Magnetic Resonance Imaging (MRI)

   Rochester, Minn.

   The purpose of this study is to prospectively determine if magnetic resonance imaging (MRI) in patients with cardiac implantable electronic devices (CIED) results in myocardial injury as assessed by changes in high sensitivity cardiac troponin T (hs-cTnT) assay. This will be done by comparing pre-and-post MRI hs-cTnT levels in these patients.

6. A Study to Examine Stress Management and Resilience Training (SMART) Outcomes Using Voice Analysis for Depression and Anxiety

   Rochester, Minn.

   The purpose of this study is to validate screening for depression and anxiety using the Ellipsis Health (EH) application, based on a person’s speech patterns and content.

7. Early Identification of Chemotherapy Induced Cardiac Toxicity

   Rochester, Minn.

   The purpose of this study is to determine whether changes in the following parameters of cardiac function with low intensity exercise occur following (1) treatment with cancer therapeutics or (2) cardiac rehabilitation:

   • 2D and 3D left ventricular (LV) longitudinal strain and strain rate.
   • Right ventricular (RV) longitudinal strain and strain rate.
   • LV circumferential and radial strain and strain rate.
   • 2D and 3D wall motion.
   • 2D and 3D volumetric LVEF.
   • Mitral valve inflow velocities (E, A) and mitral annular tissue Doppler (e’, a’).
   • Tricuspid tissue velocities and TAPSE.

   The study will also determine whether changes after treatment with cancer therapeutics or a period of cardiac rehabilitation in any of the aforementioned parameters of cardiac function with low intensity exercise:

   • Occur before changes in resting strain or resting LVEF/
   • Predict future reductions in LVEF (cardiotoxicity) or in the case of cardiac rehabilitation, prevention of LVEF decrease/
   • Predict the development of clinical heart failure/

    

    

8. Spontaneous Coronary Artery Dissection: Mechanistic Evaluation

   Rochester, Minn.

   The purpose of this study is to screen for unique or characteristic circulating peptides, hormonal biomarkers and circulating mRNA in patients who have experienced spontaneous coronary artery dissection (SCAD).

    

9. A Study of Pacemakers to Treat Slow Heart Rate in Patients With Heart Failure

   Rochester, Minn.

   Determine the impact of restoring normal heart rate response during exercise and daily activity in patients with heart failure and a preserved ejection fraction (HFpEF) and chronotropic incompetence (CI).

10. Prospective Identification of Long QT Syndrome in Fetal Life

    Rochester, Minn.

    The postnatal diagnosis of Long QT Syndrome (LQTS) is suggested by a prolonged QT interval on 12 lead electrocardiogram (ECG),a positive family history and/or characteristic arrhythmias and confirmed by genetic testing.  LQTS testing cannot be performed successfully before birth as   fetal ECG is not possible and direct measure of the fetal QT interval by magnetocardiography is limited. Genetic testing can be performed in utero, but there is risk to the pregnancy and the fetus. Although some fetuses present with arrhythmias easily recognized as LQTS (torsade des pointes (TdP) and/or 2° atrioventricular (AV) block, this is uncommon, occurring in <25% of fetal LQTS cases. Rather, the most common presentation of fetal LQTS is sinus bradycardia, a subtle rhythm disturbance that often is unappreciated to be abnormal. Consequently, the majority of LQTS cases are unsuspected and undiagnosed during fetal life, with dire consequences. For example, maternal medications commonly used during pregnancy can prolong the fetal QT interval and may provoke lethal fetal ventricular arrhythmias. But the most significant consequence is the missed opportunity for primary prevention of life threatening ventricular arrhythmias after birth because the infant is not suspected to have LQTS before birth. The over-arching goal of the study is to overcome the barriers to prenatal detection of LQTS. The investigators plan to do so by developing an algorithm using fetal heart rate (FHR) which will discriminate fetuses with or without LQTS. Immediate Goal: The investigators propose a multicenter pre-birth observational cohort study to develop a Fetal Heart Rate (FHR)/Gestational Age (GA) algorithm from a cohort of fetuses recruited from 13 national and international centers where one parent is known by prior genetic testing to have a mutation in one of the common LQTS genes: potassium voltage-gated channel subfamily Q member 1 (KCNQ1), potassium voltage-gated channel subfamily H member 2 (KCNH2), or sodium voltage-gated channel alpha subunit 5 (SCN5A). The investigators have chosen this population because 1) These mutations are the most common genetic causes of LQTS, and 2) Offspring will have high risk of LQTS as inheritance of these LQTS gene mutations is autosomal dominant. Thus, progeny of parents with a known mutation are at high (50%) risk of having the same parental LQTS mutation. The algorithm will be developed using FHR measured serially throughout pregnancy. All offspring will undergo postnatal genetic testing for the parental mutation as the gold standard for diagnosing the presence or absence of LQTS.