Medicina cardiovascular

A continuación, se enumeran los ensayos clínicos actuales.

Filtra esta lista de estudios por sede, estatus, etc.

1. A Study to Evaluate NT-proBNP Levels in the Prediction of Intrapartum and Postpartum Events in Adult Congenital Heart Disease Patients

   Rochester, Minn.

   The purpose of this study is to characterize the relationship between NT-proBNP levels obtained at time of admission for delivery and subsequent cardiovascular events in ACHD patients, and to describe normative values for NT-proBNP at time of admission for delivery in an uncomplicated obstetric population.

2. A Study of Biomarkers for Human Heart Failure

   Rochester, Minn.

   The purpose of this study is to attempt to establish the various ranges of proteins that can be assayed from the plasma and urine of patients with all classes of heart failure and MI (myocardial infarction).

3. A Study of Long-Term Outcomes of Cardiac Resynchronization Therapy Recipients with Congestive Heart Failure

   Rochester, Minn.

   The purpose of this study is to determine the long-term outcome of cardiac resynchronization therapy (CRT) recipients with congestive heart failure and any indications for CRT at Mayo Clinic.   

4. Neural Circulatory Control and SUDEP Risk.

   Rochester, Minn.

   The investigators believe epilepsy alters the way the body controls blood pressure, heart rate and breathing, and these changes increase the risk of sudden unexpected death in patients with epilepsy (SUDEP). SUDEP-7 is a risk scoring tool which may correlate with these changes to the heart and blood vessels. This research study measures those differences which may help identify new markers to help predict those patients at greatest risk in the future.

5. A Study to Evaluate Long-term Outcomes of Alcohol Septal Ablation for Hypertrophic Cardiomyopathy

   Rochester, Minn.

   The purpose of this study is to determine long term vital status, symptoms, and need for repeat procedure after alcohol septal ablation, to determine patient and procedural factors associated with successful alcohol septal ablation and need for repeat procedure, and to determine the impact of conduction abnormalities after alcohol septal ablation on long-term outcomes.

6. A Study to Evaluate Sex and Age Differences in Ehlers Danlos Syndrome Patients

   Jacksonville, Fla.

   The purpose of this study is to determine whether serum biomarkers and comorbidities differ between subjects with hEDS/HSD vs. other non-hypermobile EDS subtypes and whether sex and/or age differences exist, and to determine whether serum biomarkers and comorbidities differ between subjects with hEDS vs. HSD and whether sex and/or age differences exist.

7. A Study of the Mayo Clinic College of Medicine Ultrasound System

   Rochester, Minn.

   The purpose of this study is is to assess the EPIQ-Affiniti and NG Compact ultrasound systems in a clinical environment and collect clinical data and feedback when compared to the site’s standard ultrasound system.

8. Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis Trial

   Rochester, Minn., Jacksonville, Fla.

   Carotid revascularization for primary prevention of stroke (CREST-2) is two independent multicenter, randomized controlled trials of carotid revascularization and intensive medical management versus medical management alone in patients with asymptomatic high-grade carotid stenosis. One trial will randomize patients in a 1:1 ratio to endarterectomy versus no endarterectomy and another will randomize patients in a 1:1 ratio to carotid stenting with embolic protection versus no stenting. Medical management will be uniform for all randomized treatment groups and will be centrally directed.

9. Identification of Novel Genetic Variants and Biomarkers of Disease Progression in Arrhythmogenic Cardiomyopathy

   Rochester, Minn.

   The purpose of this study is to identify hereditary causes of cardiomyopathy.

10. International Bicuspid Aortic Valve Consortium (BAVCon)

    Rochester, Minn.

    Bicuspid aortic valve (BAV) disease is the most frequent congenital cardiac malformation, occurring in 0.5-1.2% of the US population. In young adults, it is generally a benign abnormality; but in older adults it is associated with thoracic aortic aneurysm or dissection in 20-30% of those with BAV. BAV is strongly associated with early development of aortic valve calcification or incompetence in >50% of BAV patients, and accounts for ~40% of the >30,000 aortic valve replacements (AVR) performed in the US each year. Yet, we know little of the etiology, cellular events and modifiers of progression of BAV to calcific aortic valve disease and we still do not understand the genetic cause(s) of BAV despite evidence for its high heritability.

    The Specific Aims of this study are:

    1. To identify the genetic causes of bicuspid aortic valve disease and its associated thoracic aortic disease.

    2. To identify potential pathways to predict the clinical course of BAV disease and for treating human BAV disease.

    To achieve these aims, we have created the International Bicuspid Aortic Valve Consortium (BAVCon), a consortium of institutions with cohorts of BAV patients and the expertise to fulfill the performance of these aims.