Proper Use

Drug information provided by: IBM Micromedex

Use this medicine only as directed by your doctor. Do not use more of it and do not use it more often than your doctor ordered. To do so may increase the chance of side effects.

This medicine usually comes with patient information insert and patient instructions. Read and follow the instructions carefully. Ask your doctor if you have any questions.

This medicine is for use only in the nose. Do not get any of it in your eyes or on your skin. If it does get on these areas, rinse it off right away. Do not shake the bottle.

To use the spray:

  • When you use the varenicline nasal spray for the first time, you must prime the spray. Press down fully 7 times into the air away from the face.
  • Prime the spray if you have not used it for more than 5 days, by spraying the medicine 1 time into the air. Do not prime it for more than needed.
  • Gently blow your nose to clear the nostrils before you use this medicine. Remove the cap and clip. Do not throw away the cap or the clip.
  • Tilt your head back, without lying down, and insert the spray tip into your nostril. Hold the bottle upright and aim the spray tip towards the top of the ear on the same side as your nostril. Do not spray it against the wall of the inside of your nose.
  • Place your tongue on the roof of your mouth. Press the pump 1 time and breath gently at the same time.
  • Repeat in your other nostril using the same steps.
  • Wipe the spray tip with a clean tissue and put the clip and the cap back on.


The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For nasal dosage form (spray):
    • For treatment of the signs and symptoms of dry eye disease:
      • Adults—1 spray in each nostril 2 times a day (at least 12 hours apart). Each spray contains 0.03 milligrams (mg) of varenicline.
      • Children—Use and dose must be determined by your doctor.

Missed Dose

If you miss a dose of this medicine, skip the missed dose and go back to your regular dosing schedule. Do not double doses.


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Throw this medicine away 30 days after opening the bottle.