Precautions

Drug information provided by: Merative, Micromedex®

It is very important that your doctor check your progress at regular visits to make sure this medicine is working properly. Blood and urine tests may also be needed to check for unwanted effects.

Using this medicine while you are pregnant can harm your unborn baby. If you are a woman who can bear children, your doctor may give you a pregnancy test before you start using this medicine to make sure you are not pregnant. Use an effective form of birth control during treatment and for at least 4 months after the last dose. If you think you have become pregnant while using this medicine, tell your doctor right away.

Contact your doctor right away if you have any changes in your heart rhythm. You might feel dizzy, faint, or have a fast, pounding, or uneven heartbeat. Make sure your doctor knows if you or anyone in your family has ever had a heart rhythm problem such as QT prolongation.

Serious skin reactions can occur with this medicine. Check with your doctor right away if you have blistering, peeling, or loosening of the skin, red skin lesions, severe acne or skin rash, sores or ulcers on the skin, or fever or chills while you are using this medicine.

Avoid overexposing your skin to sunlight. Always use sunscreen or sun-blocking lotions and wear protective clothing and hats while you are using this medicine and for 4 months after the last dose.

Call your doctor right away if you have trouble breathing, cough, and fever that comes on suddenly. These may be symptoms of a serious lung condition.

Call your doctor right away if you have confusion, difficulty with speaking, slow speech, an inability to speak, an inability to move your arms, legs, or facial muscles, double vision, or a headache. These may be symptoms of a stroke.

This medicine may increase your chance of bleeding. Tell your doctor right away if you have bleeding gums, coughing up blood, difficulty in breathing or swallowing, dizziness, headache, increased menstrual flow or vaginal bleeding, nosebleeds, prolonged bleeding from cuts, red or dark brown urine, or red or black, tarry stools. To help with this problem, stay away from rough sports or other situations where you could be bruised, cut, or injured. Brush and floss your teeth gently. Be careful when using sharp objects, including razors and fingernail clippers.

Check with your doctor right away if you have chest pain, decreased urine output, dilated neck veins, extreme fatigue, irregular breathing, irregular heartbeat, swelling of the face, fingers, feet, or lower legs, tightness in the chest, trouble breathing, or weight gain. These may be signs of a heart condition called congestive heart failure (CHF).

This medicine may cause diarrhea. This may also increase your risk of having an electrolyte imbalance (eg, low potassium, magnesium, or calcium in the blood). Tell your doctor right away if you start having muscle cramps or twitching, mood or mental changes, or unusual tiredness or weakness while using this medicine.

This medicine may cause hypothyroidism (underactive thyroid gland). Check with your doctor right away if you have constipation, a depressed mood, dry skin and hair, feeling cold, hair loss, hoarseness or husky voice, muscle cramps and stiffness, a slow heartbeat, weight gain, or unusual tiredness or weakness.

Your blood pressure might get too high while you are using this medicine. This may cause headaches, dizziness, or blurred vision. You might need to measure your blood pressure at home. If you think your blood pressure is too high, call your doctor right away.

Check with your doctor if you have a headache, seizures, confusion, blurred vision or any other changes in vision. These may be symptoms of a rare and serious condition called reversible posterior leukoencephalopathy syndrome (RPLS).

This medicine may cause slow wound healing. Make sure any doctor or dentist who treats you knows that you are using this medicine. You may need to stop using it for at least 1 month before and at least 2 weeks after having surgery.

This medicine may cause blurred vision, tiredness, or weakness. Do not drive or do anything else that could be dangerous until you know how this medicine affects you.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or non-prescription (over-the-counter [OTC]) medicines and herbal (St. John's wort) or vitamin supplements.

Portions of this document last updated: Nov. 01, 2023