Before Using
Drug information provided by: Merative, Micromedex®
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:
Allergies
Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Pediatric
Appropriate studies have not been performed on the relationship of age to the effects of Ryzolt™ in children younger than 16 years of age. Safety and efficacy have not been established.
Conzip® extended-release capsules, Qdolo® oral liquid, and Ultram® tablets should not be used in children younger than 12 years of age. It should not be used to relieve pain after surgery removal of tonsils or adenoids in any children. Severe breathing problems and deaths have been reported in some children who received tramadol after tonsil or adenoid surgery.
Appropriate studies have not been performed on the relationship of age to the effects of tramadol extended-release tablets in the pediatric population. Safety and efficacy have not been established.
Geriatric
Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of tramadol in the elderly. However, elderly patients are more likely to have unwanted side effects (eg, constipation, lightheadedness, dizziness, or fainting, stomach upset, weakness) and age-related liver, kidney, heart, or lung problems, which may require caution and an adjustment in the dose for patients receiving tramadol.
Breastfeeding
Studies in women breastfeeding have demonstrated harmful infant effects. An alternative to this medication should be prescribed or you should stop breastfeeding while using this medicine.
Drug Interactions
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.
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Isocarboxazid
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Linezolid
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Mavorixafor
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Methylene Blue
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Moclobemide
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Nalmefene
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Naltrexone
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Ozanimod
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Phenelzine
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Procarbazine
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Rasagiline
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Safinamide
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Samidorphan
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Selegiline
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Tranylcypromine
Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
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Abiraterone Acetate
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Acepromazine
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Aclidinium
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Alfentanil
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Almotriptan
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Alprazolam
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Amantadine
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Amifampridine
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Amiloride
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Amineptine
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Amiodarone
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Amitriptyline
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Amitriptylinoxide
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Amobarbital
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Amoxapine
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Amphetamine
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Amprenavir
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Anileridine
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Apalutamide
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Aprepitant
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Aripiprazole
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Aripiprazole Lauroxil
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Armodafinil
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Asenapine
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Atazanavir
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Atropine
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Avacopan
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Baclofen
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Belladonna
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Belzutifan
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Bemetizide
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Bendroflumethiazide
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Benperidol
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Bentazepam
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Benzhydrocodone
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Benzphetamine
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Benzthiazide
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Benztropine
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Biperiden
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Boceprevir
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Bosentan
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Bromazepam
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Bromopride
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Bromperidol
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Brompheniramine
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Bumetanide
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Buprenorphine
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Bupropion
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Buspirone
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Butabarbital
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Butalbital
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Butorphanol
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Calcium Oxybate
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Cannabidiol
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Cannabis
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Canrenoate
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Canrenone
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Carbamazepine
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Carbinoxamine
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Carisoprodol
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Carphenazine
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Cenobamate
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Ceritinib
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Cetirizine
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Chloral Hydrate
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Chlordiazepoxide
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Chlorothiazide
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Chlorpheniramine
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Chlorpromazine
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Chlorthalidone
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Chlorzoxazone
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Cilostazol
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Cimetidine
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Cinacalcet
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Ciprofloxacin
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Citalopram
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Clarithromycin
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Clemastine
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Clidinium
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Clobazam
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Clofazimine
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Clomipramine
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Clonazepam
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Clopamide
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Clopidogrel
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Clorazepate
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Cloxazolam
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Clozapine
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Cobicistat
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Cocaine
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Codeine
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Conivaptan
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Crizotinib
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Cyclobenzaprine
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Cyclopenthiazide
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Cyclopentolate
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Cyclosporine
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Cyclothiazide
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Cyproheptadine
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Dabrafenib
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Dantrolene
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Daridorexant
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Darifenacin
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Darunavir
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Delavirdine
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Delorazepam
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Desipramine
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Desmopressin
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Desvenlafaxine
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Dexamethasone
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Dexmedetomidine
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Dextroamphetamine
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Dextromethorphan
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Dezocine
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Diacetylmorphine
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Diazepam
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Diazoxide
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Dibenzepin
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Dichloralphenazone
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Dicloxacillin
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Dicyclomine
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Difenoxin
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Digoxin
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Dihydrocodeine
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Diltiazem
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Dimenhydrinate
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Diphenhydramine
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Diphenoxylate
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Dipyrone
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Dolasetron
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Donepezil
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Dothiepin
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Doxepin
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Doxylamine
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Dronedarone
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Droperidol
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Duloxetine
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Duvelisib
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Efavirenz
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Elagolix
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Eletriptan
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Eliglustat
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Enflurane
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Enzalutamide
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Eplerenone
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Erythromycin
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Escitalopram
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Esketamine
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Eslicarbazepine Acetate
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Estazolam
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Eszopiclone
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Ethacrynic Acid
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Ethchlorvynol
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Ethopropazine
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Ethylmorphine
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Etozolin
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Etravirine
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Fedratinib
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Fenfluramine
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Fentanyl
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Fesoterodine
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Flavoxate
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Flecainide
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Flibanserin
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Fluconazole
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Flunitrazepam
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Fluoxetine
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Fluphenazine
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Flurazepam
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Fluspirilene
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Fluvoxamine
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Fosamprenavir
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Fosaprepitant
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Fosnetupitant
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Fosphenytoin
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Fospropofol
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Frovatriptan
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Furosemide
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Gabapentin
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Gabapentin Enacarbil
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Gepirone
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Glycopyrrolate
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Glycopyrronium Tosylate
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Granisetron
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Halazepam
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Haloperidol
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Halothane
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Hexobarbital
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Homatropine
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Hydrochlorothiazide
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Hydrocodone
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Hydroflumethiazide
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Hydromorphone
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Hydroxyamphetamine
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Hydroxytryptophan
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Hydroxyzine
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Hyoscyamine
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Idelalisib
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Imatinib
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Imipramine
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Indapamide
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Indinavir
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Ipratropium
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Isoflurane
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Itraconazole
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Ivacaftor
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Ivosidenib
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Ketamine
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Ketazolam
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Ketobemidone
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Ketoconazole
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Lacosamide
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Larotrectinib
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Lasmiditan
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Lemborexant
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Lenacapavir
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Lesinurad
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Letermovir
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Levocetirizine
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Levoketoconazole
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Levomilnacipran
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Levorphanol
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Lisdexamfetamine
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Lithium
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Lofepramine
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Lofexidine
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Lomitapide
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Lonafarnib
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Loprazolam
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Lorazepam
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Lorcaserin
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Lorlatinib
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Lormetazepam
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Loxapine
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Lumacaftor
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Magnesium Oxybate
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Maribavir
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Meclizine
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Medazepam
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Melitracen
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Melperone
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Mepenzolate
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Meperidine
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Mephobarbital
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Meprobamate
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Meptazinol
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Mesoridazine
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Metaclazepam
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Metaxalone
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Methadone
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Methamphetamine
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Methdilazine
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Methocarbamol
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Methohexital
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Methotrexate
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Methotrimeprazine
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Methyclothiazide
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Methylprednisolone
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Metoclopramide
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Metolazone
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Midazolam
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Mifepristone
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Milnacipran
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Mirtazapine
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Mitotane
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Mobocertinib
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Modafinil
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Molindone
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Moricizine
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Morphine
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Morphine Sulfate Liposome
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Nafcillin
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Nalbuphine
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Naratriptan
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Nefazodone
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Nelfinavir
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Netupitant
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Nevirapine
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Nicomorphine
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Nilotinib
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Nitrazepam
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Nitrous Oxide
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Nordazepam
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Nortriptyline
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Olanzapine
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Oliceridine
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Ondansetron
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Opipramol
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Opium
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Opium Alkaloids
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Orphenadrine
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Oxazepam
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Oxcarbazepine
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Oxitropium Bromide
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Oxybutynin
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Oxycodone
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Oxymorphone
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Palbociclib
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Palonosetron
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Papaveretum
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Paregoric
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Paritaprevir
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Paroxetine
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Peginterferon Alfa-2b
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Pentazocine
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Pentobarbital
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Perampanel
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Perazine
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Periciazine
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Perphenazine
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Phenobarbital
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Phenytoin
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Pimozide
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Pinazepam
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Pipenzolate Bromide
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Piperacetazine
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Pipotiazine
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Pirenzepine
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Piretanide
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Piritramide
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Polythiazide
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Posaconazole
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Potassium Oxybate
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Prazepam
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Prednisone
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Pregabalin
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Primidone
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Prochlorperazine
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Procyclidine
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Promazine
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Promethazine
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Propantheline
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Propiverine
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Propofol
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Protriptyline
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Quazepam
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Quetiapine
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Quinethazone
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Quinine
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Ramelteon
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Ranitidine
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Ranolazine
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Remifentanil
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Remimazolam
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Remoxipride
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Ribociclib
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Rifabutin
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Rifampin
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Rifapentine
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Ritlecitinib
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Ritonavir
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Rizatriptan
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Rolapitant
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Ropeginterferon Alfa-2b-njft
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Saquinavir
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Schisandra sphenanthera
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Scopolamine
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Secobarbital
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Sertindole
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Sertraline
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Sibutramine
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Sodium Oxybate
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Solifenacin
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Spironolactone
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St John's Wort
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Stramonium
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Sufentanil
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Sulpiride
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Sumatriptan
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Suvorexant
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Tapentadol
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Telaprevir
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Telithromycin
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Telotristat Ethyl
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Temazepam
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Terbinafine
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Terodiline
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Tetrazepam
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Thiethylperazine
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Thiopental
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Thiopropazate
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Thioridazine
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Thiothixene
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Tianeptine
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Ticagrelor
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Tilidine
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Tiotropium
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Tipranavir
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Tizanidine
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Tolonium Chloride
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Tolterodine
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Topiramate
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Torsemide
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Trazodone
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Triamterene
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Triazolam
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Trichlormethiazide
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Trifluoperazine
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Trifluperidol
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Triflupromazine
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Trihexyphenidyl
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Trimeprazine
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Trimipramine
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Troleandomycin
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Tropicamide
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Trospium
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Tryptophan
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Tucatinib
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Umeclidinium
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Venlafaxine
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Verapamil
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Vilazodone
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Vonoprazan
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Voriconazole
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Vortioxetine
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Voxelotor
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Warfarin
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Xipamide
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Zaleplon
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Ziprasidone
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Zolmitriptan
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Zolpidem
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Zopiclone
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Zotepine
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Zuranolone
Other Interactions
Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using this medicine with any of the following is usually not recommended, but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.
Other Medical Problems
The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:
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Adrenal problems or
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Alcohol abuse, history of or
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Brain tumor or
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Depression, history of or
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Diabetes or
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Drug abuse or dependence, history of or
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Gallstones or
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Head injury or
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Hormonal problems or
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Increased pressure in the head or
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Infections of the central nervous system (CNS) or
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Lung or breathing problems (eg, COPD, cor pulmonale, hypercapnia, hypoxia, sleep apnea) or
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Mental illness (eg, suicidal ideation), history of or
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Phenylketone allergy, history of or
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Seizures or epilepsy, history of or
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Stomach problems, severe—Use with caution. May increase risk for more serious side effects.
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Asthma, acute or severe or
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Lung or breathing problems, severe or
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Stomach or bowel blockage (eg, paralytic ileus) or
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Surgery (eg, nasopharyngeal tonsils, tonsils)—Should not be used in patients with these conditions.
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Kidney disease or
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Liver disease (including cirrhosis)—Use with caution. The effects may be increased because of slower removal of the medicine from the body.
Portions of this document last updated: Aug. 01, 2024
Copyright: © Merative US L.P. 1973, 2024. All rights reserved. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes.