Before Using

Drug information provided by: Merative, Micromedex®

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Children are usually more sensitive than adults to the effects of phenothiazine medicines such as thiethylperazine. Certain side effects, such as muscle spasms of the face, neck, and back, tic-like or twitching movements, inability to move the eyes, twisting of the body, or weakness of the arms and legs, are more likely to occur in children, especially those with severe illness or dehydration.

Geriatric

Elderly patients are usually more sensitive to the effects of phenothiazine medicines such as thiethylperazine. Confusion; difficult or painful urination; dizziness; drowsiness; feeling faint; or dryness of mouth, nose, or throat may be more likely to occur in elderly patients. Also, nightmares or unusual excitement, nervousness, restlessness, or irritability may be more likely to occur in elderly patients. In addition, uncontrolled movements may be more likely to occur in elderly patients taking thiethylperazine.

Breastfeeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Drug Interactions

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

  • Saquinavir

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Alfentanil
  • Alprazolam
  • Amifampridine
  • Apomorphine
  • Benzhydrocodone
  • Bromazepam
  • Buprenorphine
  • Bupropion
  • Butorphanol
  • Calcium Oxybate
  • Cannabidiol
  • Cannabis
  • Cetirizine
  • Clobazam
  • Clonazepam
  • Codeine
  • Daridorexant
  • Dexmedetomidine
  • Dihydrocodeine
  • Donepezil
  • Doxylamine
  • Duloxetine
  • Epinephrine
  • Esketamine
  • Fentanyl
  • Flibanserin
  • Gabapentin
  • Gabapentin Enacarbil
  • Gatifloxacin
  • Hydrocodone
  • Hydromorphone
  • Ibutilide
  • Isradipine
  • Ketamine
  • Lacosamide
  • Lemborexant
  • Levocetirizine
  • Levorphanol
  • Lofexidine
  • Loxapine
  • Magnesium Oxybate
  • Meperidine
  • Methadone
  • Metoclopramide
  • Metrizamide
  • Morphine
  • Morphine Sulfate Liposome
  • Nalbuphine
  • Octreotide
  • Olanzapine
  • Oliceridine
  • Oxycodone
  • Oxymorphone
  • Pentamidine
  • Pentazocine
  • Periciazine
  • Phenobarbital
  • Porfimer
  • Potassium Oxybate
  • Pregabalin
  • Primidone
  • Procarbazine
  • Remifentanil
  • Remimazolam
  • Ropeginterferon Alfa-2b-njft
  • Sodium Oxybate
  • Sufentanil
  • Tapentadol
  • Topiramate
  • Tramadol
  • Zolpidem
  • Zuranolone

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Aminolevulinic Acid
  • Belladonna
  • Belladonna Alkaloids
  • Betel Nut
  • Evening Primrose
  • Phenylalanine

Other Interactions

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following may cause an increased risk of certain side effects but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.

  • Ethanol

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Alcohol abuse—This medicine, if taken together with alcohol, may lower the blood pressure and cause CNS depressant effects, such as severe drowsiness
  • Asthma attack or
  • Other lung diseases—Thiethylperazine may cause secretions to become thick so that it might be difficult to cough them up, for example, during an asthma attack
  • Blood disease or
  • Heart or blood vessel disease—This medicine may cause more serious conditions to develop
  • Difficult urination or
  • Enlarged prostate—This medicine may cause urinary problems to get worse
  • Glaucoma—This medicine may cause an increase in inner eye pressure
  • Liver disease—Thiethylperazine may accumulate in the body, increasing the chance of side effects, such as muscle spasms
  • Parkinson's disease or
  • Seizure disorders—The chance of thiethylperazine causing seizures or uncontrolled movements is greater when these conditions are present

Portions of this document last updated: May 01, 2024

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