Proper Use

Drug information provided by: Merative, Micromedex®

Your doctor will test the testosterone levels in your blood before you start and while you are using this medicine.

This medicine comes with a patient information leaflet. Read and follow these instructions carefully. Ask your doctor if you have any questions.

This medicine is for use only in the nose. Do not get any of it in your eyes or on your skin. If it does get on these areas, rinse it off right away.

To use:

  • If you are using this medicine for the first time, you will need to prime the pump. To do this, hold the Natesto® pump over a sink, turn it upside down, and slowly press the pump for 10 times.
  • If any medicine comes out during priming, discard it into the sink and rinse down the drain with warm water.
  • Wipe the tip with a clean, dry tissue if there is any medicine left on the tip of the pump. Now it is ready to use.
  • If you get the medicine on your hands, wash it away with warm water and soap.
  • Gently blow your nose to clear the nostrils.
  • While looking in the mirror, insert the tip of the pump into your left nostril and gently tilt it so that it touches the side wall of your nostrils to ensure it is applied properly.
  • Slowly press the pump until it stops and remove the tip slowly from your nose.
  • Do the same steps applying the medicine into your right nostril.
  • After using the pump, wipe the tip with a clean, dry tissue and put the cap back on.
  • Press your nostrils together just below the middle of your nose and lightly rub them together.
  • Do not blow your nose or sniff 1 hour after using this medicine.


The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For nasal dosage form (gel):
    • For hormone replacement:
      • Adults—11 milligrams (mg), or 1 pump actuation in each nostril, 3 times a day (once in the morning, once in the afternoon, and once in the evening, about 6 to 8 hours apart).
      • Children—Use and dose must be determined by your doctor.

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.


Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep the medicine in a safe place. Do not give it to anyone else, even if you have the same symptoms.