Before Using

Drug information provided by: Merative, Micromedex®

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of Depo®-Testosterone in children younger than 12 years of age. Safety and efficacy have not been established.

Appropriate studies have not been performed on the relationship of age to the effects of Aveed® or Xyosted™ in the pediatric population. Safety and efficacy have not been established.

Although Delatestryl® may be used for short periods of time in certain male teenagers to treat delayed puberty. X-ray exams of the hands and wrists of male teenagers should be made every 6 months while receiving this medicine.

Geriatric

Appropriate studies on the relationship of age to the effects of testosterone injection have not been performed in the geriatric population. However, elderly patients are more likely to have heart or prostate problems (including enlarged prostate), which may require caution in patients receiving this medicine.

Breastfeeding

Studies in women breastfeeding have demonstrated harmful infant effects. An alternative to this medication should be prescribed or you should stop breastfeeding while using this medicine.

Drug Interactions

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Anisindione
  • Apixaban
  • Bupropion
  • Dabigatran Etexilate
  • Dicumarol
  • Edoxaban
  • Insulin
  • Insulin Aspart, Recombinant
  • Insulin Bovine
  • Insulin Degludec
  • Insulin Detemir
  • Insulin Glulisine
  • Insulin Lispro, Recombinant
  • Levoketoconazole
  • Methotrexate
  • Paclitaxel
  • Paclitaxel Protein-Bound
  • Phenprocoumon
  • Rivaroxaban
  • Warfarin

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Licorice

Other Interactions

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Allergy to benzyl benzoate, refined castor oil, or sesame oil or
  • Breast cancer (in males) or
  • Hypogonadism, age-related or
  • Prostate cancer, known or suspected—Aveed®, Delatestryl®, or Xyosted™ should not be used in patients with these conditions.
  • Blood clotting problems (eg, deep vein thrombosis, pulmonary embolism) or
  • Coronary artery disease or
  • Diabetes or
  • Drug abuse or dependence, or history of or
  • Enlarged prostate or
  • Heart attack, or history of or
  • Hypercalcemia (high calcium in the blood) or
  • Hyperlipidemia (high cholesterol or fats in the blood) or
  • Hypertension (high blood pressure) or
  • Liver problems or
  • Problems in passing urine or
  • Sleep apnea (breathing problem)—Use with caution. May make these conditions worse.
  • Blood disorder (eg, polycythemia)—May increase risk for thromboembolic diseases (blood clots).
  • Heart disease (eg, congestive heart failure) or
  • Kidney disease or
  • Liver disease—Use with caution. Testosterone may cause edema (fluid retention) in patients with these conditions.
  • Heart disease, severe or
  • Kidney disease, severe or
  • Liver disease, severe—Depo®-Testosterone should not be used in patients with these conditions.

Portions of this document last updated: April 01, 2024

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