Description and Brand Names
Drug information provided by: Merative, Micromedex®
US Brand Name
Succimer is used in the treatment of acute lead poisoning to remove excess lead from the body, especially in small children.
Succimer combines with lead in the blood stream. The combination of lead and succimer is then removed from the body by the kidneys. By removing the excess lead, the medicine lessens damage to various organs and tissues of the body.
This product is available in the following dosage forms:
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:
Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
This medicine has been tested in children over the age of 1 year and, in effective doses, has not been shown to cause different side effects or problems than it does in adults.
Many medicines have not been studied specifically in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults or if they cause different side effects or problems in older people. There is no specific information comparing use of succimer in the elderly with use in other age groups.
There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.
Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.
Other Medical Problems
The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:
Dehydration—Before and while taking succimer, you must drink plenty of fluids and urinate regularly
Kidney disease—The combination of lead and succimer may not be removed from the body as quickly as it normally would
Liver disease—This condition may be made worse; your doctor should perform liver function tests regularly while you are taking succimer
Children who have too much lead in their bodies should be removed from the lead-containing environment (for example, home, school, or other areas where the child has been exposed to lead) until the lead has been removed from the environment. If this is not possible, the environment should be made as safe as possible for the child.
Your doctor may want to put your child in the hospital while he or she is receiving succimer. This will allow the doctor to check your child's condition while the lead can be removed from the child's environment.
When opening your bottle of succimer, you may notice an unpleasant odor. However, this is a normal odor for these capsules and does not affect how the medicine works.
If the capsules cannot be swallowed, the contents of the capsule may be sprinkled on food and eaten immediately. The contents may also be given on a spoon and followed by a fruit drink.
It is important to drink plenty of fluids while taking succimer.
The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.
The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.
For the oral dosage form (capsules):
For treatment of lead poisoning:
For adults and children 12 years of age or older—Dose is based on body weight. The usual dose is 10 milligrams (mg) of succimer per kilogram (kg) (4.5 mg per pound) of body weight every eight hours for five days.
For children 1 to 11 years of age—Dose is based on body weight. The usual dose is 10 mg of succimer per kg (4.5 mg per pound) of body weight every eight hours for five days. The same dose is then given every twelve hours for the next fourteen days, for a total of nineteen days of therapy.
For children up to 1 year of age—Use and dose must be determined by your doctor.
If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.
Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.
Keep out of the reach of children.
Do not keep outdated medicine or medicine no longer needed.
It is important that your doctor check your progress at regular visits to make sure that this medicine is working properly and to prevent unwanted effects. Certain blood and urine tests must be done regularly to determine how long you need to take succimer.
If you think you are getting an infection or if you get a fever or chills, contact your doctor as soon as possible. You will need certain tests. Based on the results of the tests, your doctor may advise you to temporarily stop taking succimer to prevent serious side effects from occurring.
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor as soon as possible if any of the following side effects occur:
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
loss of appetite
nausea and vomiting
Succimer may cause your urine, sweat, and feces to have an unpleasant odor.
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
Portions of this document last updated: Feb. 01, 2023
Original article: https://www.mayoclinic.org/drugs-supplements/succimer-oral-route/side-effects/drg-20066140
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