Proper Use

Drug information provided by: Merative, Micromedex®

Take this medicine exactly as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered.

This medicine should come with a patient information leaflet. Read and follow the information carefully. Ask your doctor if you have any questions.

Keep using this medicine for the full time of treatment, even if you begin to feel better after a few days. Also, it is important to keep the amount of medicine in your body at a steady level. To help keep the amount constant, this medicine must be used on a regular schedule.

You may take this medicine with or without food.

Swallow the tablet whole. Do not crush, break, or chew it.

If you are taking an antacid containing aluminum or magnesium, take it 4 hours before or after you take this medicine.

To use oral pellets:

  • You may take the oral pellets with food or directly in your mouth.
  • If you take this medicine directly in your mouth, you may drink water after swallowing the pellets.
  • Take the oral pellets with food for children younger than 6 years of age.
  • If you take this medicine with food, shake the packet gently to settle the pellets to the bottom of packet. Mix the entire packet into a non-acidic soft food (eg, pudding, chocolate syrup, or ice cream) in a bowl and mix it with a spoon. Take the mixture within 15 minutes.
  • Do not chew the oral pellets or the mixture to avoid bitter taste.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For oral dosage form (tablets):
    • For hepatitis C virus infection:
      • Adults—One tablet once a day, taken for 12 weeks. Each tablet contains sofosbuvir 400 milligrams (mg) and velpatasvir 100 mg.
      • Children 3 years of age and older or weighing at least 30 kilograms (kg)—Dose is based on body weight and must be determined by your doctor.
        • Weighing at least 30 kilograms (kg)—One tablet (containing 400 mg sofosbuvir and 100 mg velpatasvir) once a day or two tablets (containing 200 mg sofosbuvir and 50 mg velpatasvir) taken for 12 weeks.
        • Weighing 17 to less than 30 kg—One tablet (containing 200 mg sofosbuvir and 50 mg velpatasvir) once a day taken for 12 weeks.
      • Children 3 years of age and older weighing less than 17 kg—Use of oral pellets is recommended.
      • Children younger than 3 years of age—Use and dose must be determined by your doctor.
  • For oral dosage form (pellets):
    • For hepatitis C virus infection:
      • Children 3 years of age and older or weighing at least 30 kilograms (kg)—Dose is based on body weight and must be determined by your doctor.
        • Weighing at least 30 kilograms (kg)—Two packets (containing 200 mg sofosbuvir and 50 mg velpatasvir, total of 400 mg sofosbuvir and 100 mg velpatasvir) once a day taken for 12 weeks.
        • Weighing 17 to less than 30 kg—One packet (containing 200 mg sofosbuvir and 50 mg velpatasvir) once a day taken for 12 weeks.
        • Weighing less than 17 kg—One packet (containing 150 mg sofosbuvir and 37.5 mg velpatasvir) once a day taken for 12 weeks.
      • Children younger than 3 years of age—Use and dose must be determined by your doctor.

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep the medicine in its original container until you are ready to use it. Throw away any unused medicine. Do not store and reuse any leftover pellets or mixture.

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Portions of this document last updated: April 01, 2024

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