Proper Use

Drug information provided by: IBM Micromedex

Take this medicine only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered.

This medicine should come with a Medication Guide. Read and follow the instructions carefully. Ask your doctor if you have any questions.

If you are using this medicine and have certain heart conditions, your doctor may want you to stay in the medical facility for at least 6 hours after the first dose of this medicine and after starting it again if you miss 1 or more doses.

Swallow the tablet whole. Do not split, crush, or chew it. You may take this medicine with or without food.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For oral dosage form (tablets):
    • For relapsing forms of multiple sclerosis:
      • Adults—Dose is based on your genotype and must be determined by your doctor.
        • For genotypes *1/*1, *1/*2, or *2/*2—You will need to take this medicine with a 5-day titration schedule. 0.25 milligram (mg) once a day for Days 1 and 2, 0.5 mg once a day for Day 3, 0.75 mg once a day for Day 4, and 1.25 mg once a day for Day 5. Then, a maintenance dose of 2 mg once a day starting on Day 6.
        • For genotypes *1/*3 or *2/*3—You will need to take this medicine with a 4-day titration schedule. 0.25 milligram (mg) once a day for Days 1 and 2, 0.5 mg once a day for Day 3, and 0.75 mg once a day for Day 4. Then, a maintenance dose of 1 mg once a day starting on Day 5.
      • Children—Use and dose must be determined by your doctor.

Missed Dose

Call your doctor or pharmacist for instructions.

  • If you miss a dose after the initial dose titration, take it as soon as you remember, then go back to your regular dosing schedule.
  • If you miss 1 or more doses during the initial dose titration, you will need to restart the medicine.
  • If you miss a dose for 4 days in a row, you will need to restart the dose titration.

Storage

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Store the unopened medicine in the refrigerator. Do not freeze. You may store the opened medicine in its original container at room temperature for up to 3 months after opening. Do not refrigerate after opening.