Proper Use

Drug information provided by: Merative, Micromedex®

Take this medicine exactly as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. To do so may increase the chance of side effects.

This medicine comes with a patient information insert. Read and follow the instructions carefully. Ask your doctor if you have any questions.

For children who cannot swallow the tablets, your pharmacist will mix this medicine as a liquid suspension. Shake the bottle of suspension well for at least 10 seconds before giving it to your child.

Dosing

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

  • For oral dosage form (tablets):
    • For heart failure:
      • For patients taking Entresto® with an ACE inhibitor or ARB:
        • Adults—At first, 1 tablet of 49 milligrams (mg) of sacubitril and 51 mg of valsartan 2 times a day. After 2 to 4 weeks, your doctor may increase your dose as needed and tolerated. However, the dose is usually not more than 1 tablet of Entresto® 97/103 mg two times a day.
        • Children 1 year of age and older and weighing at least 50 kilograms (kg)—Dose is based on body weight and must be determined by your doctor. The starting dose is 1 tablet of Entresto® 49/51 mg two times a day. Your doctor will increase your dose every 2 weeks as needed and tolerated. However, the dose is usually not more than 1 tablet of Entresto® 97/103 mg two times a day.
        • Children 1 year of age and older and weighing at least 40 kg to less than 50 kg—Dose is based on body weight and must be determined by your doctor. The starting dose is 1 tablet of Entresto® 24/26 mg two times a day. Your doctor will increase your dose every 2 weeks as needed and tolerated. However, the dose is usually not more than 3 tablets of Entresto® 24/26 mg two times a day.
        • Children 1 year of age and older and weighing less than 40 kg—Dose is based on body weight and must be determined by your doctor. The starting dose is 1.6 mg per kg of body weight two times a day. Your doctor will increase your dose every 2 weeks as needed and tolerated. However, the dose is usually not more than 3.1 mg per kg of body weight two times a day.
        • Children younger than 1 year of age—Use and dose must be determined by your doctor.
      • For patients not currently taking an ACE inhibitor or ARB and for patients previously taking low doses of ACE inhibitor or ARB:
        • Adults—At first, 1/2 tablet of Entresto® 49/51 mg two times a day. After 2 to 4 weeks, your doctor may double your dose as needed and tolerated. However, the dose is usually not more than 1 tablet of Entresto® 97/103 mg two times a day.
        • Children 1 year of age and older and weighing at least 50 kilograms (kg)—Dose is based on body weight and must be determined by your doctor. The starting dose is 1/2 tablet of Entresto® 49/51 two times a day. Your doctor will increase your dose every 2 weeks as needed and tolerated. However, the dose is usually not more than 1 tablet of Entresto® 97/103 mg two times a day.
        • Children 1 year of age and older and weighing at least 40 kg to less than 50 kg—Dose is based on body weight and must be determined by your doctor. The starting dose is 0.8 mg per kg of body weight two times a day. Your doctor will increase your dose every 2 weeks as needed and tolerated. However, the dose is usually not more than 3 tablets of Entresto® 24/26 mg two times a day.
        • Children 1 year of age and older and weighing less than 40 kg—Dose is based on body weight and must be determined by your doctor.
        • Children younger than 1 year of age—Use and dose must be determined by your doctor.

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Store the mixed oral suspension in room temperature for up to 15 days. Do not refrigerate.