Drug information provided by: IBM Micromedex
It is very important that your doctor check your progress at regular visits to make sure this medicine is working properly. Blood tests will be needed to check for unwanted effects.
If your condition does not improve within 6 months, or if it becomes worse, check with your doctor.
Ruxolitinib can temporarily lower the number of white blood cells in your blood, increasing the chance of getting an infection. It can also lower the number of platelets, which are necessary for proper blood clotting. If this occurs, there are certain precautions you can take, especially when your blood count is low, to reduce the risk of infection or bleeding:
If you can, avoid people with infections. Check with your doctor immediately if you think you are getting an infection or if you get a fever or chills, cough or hoarseness, lower back or side pain, or painful or difficult urination.
Check with your doctor immediately if you notice any unusual bleeding or bruising, black, tarry stools, blood in the urine or stools, or pinpoint red spots on your skin.
Be careful when using a regular toothbrush, dental floss, or toothpick. Your medical doctor, dentist, or nurse may recommend other ways to clean your teeth and gums. Check with your medical doctor before having any dental work done.
Do not touch your eyes or the inside of your nose unless you have just washed your hands and have not touched anything else in the meantime.
Be careful not to cut yourself when you are using sharp objects such as a safety razor or fingernail or toenail cutters.
Avoid contact sports or other situations where bruising or injury could occur.
This medicine may increase your risk of developing serious infections (eg, herpes, tuberculosis, hepatitis B, progressive multifocal leukoencephalopathy, fungal infection) . Avoid being near people who are sick or have infections while you are using this medicine. Wash your hands often. Tell your doctor if you have any kind of infection before you start using this medicine. Also tell your doctor if you have ever had an infection that would not go away or an infection that kept coming back.
You will need to have a skin test for tuberculosis (TB) before you start using this medicine. Tell your doctor if you or anyone in your home has ever had a positive reaction to a TB skin test.
This medicine may increase your risk of a serious brain infection called progressive multifocal leukoencephalopathy (PML). Call your doctor right away if you have weakness on one side of your body, loss of coordination, clumsiness, memory problems, trouble thinking clearly, or loss of interest in things.
Check with your doctor right away if you have painful blisters on the trunk of the body. These may be symptoms of herpes zoster (shingles).
This medicine may cause non-melanoma skin cancer. Tell your doctor if you have any new or changing skin lesions.
Do not stop using this medicine suddenly without asking your doctor. You may need to slowly decrease your dose before stopping it completely. This may help prevent a possible worsening of your condition and reduce the possibility of withdrawal symptoms such as a fever, chest tightness, trouble breathing, lightheadedness, dizziness, or fainting.
This medicine may increase the level of cholesterol and fat in your blood. If this occurs, your doctor may give you medicine to lower the cholesterol and fat. Talk to your doctor if you have concerns.
Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.