Description and Brand Names

Drug information provided by: Merative, Micromedex®

US Brand Name

  1. Naropin

Descriptions


Ropivacaine injection is used to cause numbness or loss of feeling in patients before and during surgery or labor and delivery. It is also used to relieve acute pain. Ropivacaine is a local anesthetic and does not cause loss of consciousness.

This medicine is to be given only by or under the direct supervision of your doctor.

This product is available in the following dosage forms:

  • Solution

Before Using

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of ropivacaine injection in the pediatric population. Safety and efficacy have not been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of ropivacaine injection in the elderly. However, elderly patients are more likely to have age-related liver, kidney, or heart problems, which may require caution and an adjustment in the dose for patients receiving this medicine.

Breastfeeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Drug Interactions

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Abametapir
  • Bupivacaine
  • Capmatinib
  • Carbamazepine
  • Hyaluronidase
  • Peginterferon Alfa-2b
  • Pixantrone
  • St John's Wort
  • Viloxazine

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Ciprofloxacin
  • Fluvoxamine

Other Interactions

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following is usually not recommended, but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.

  • Tobacco

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Glucose-6-phosphate dehydrogenase deficiency (G6PD) or
  • Heart problems or
  • Lung or breathing problems or
  • Methemoglobinemia (blood disorder), hereditary or idiopathic (unknown cause)—Use with caution. May increase risk of having methemoglobinemia.
  • Heart block or
  • Hypotension (low blood pressure) or
  • Hypovolemia (low blood volume)—Use with caution.
  • Heart or blood vessel disease—Use with caution. The chance of side effects may be increased.
  • Kidney disease, severe or
  • Liver disease, severe—Use with caution. The effects may be increased because of the slower removal of the medicine from the body.

Proper Use

A nurse or other trained health professional will give you this medicine in a medical facility. It is given through a needle placed into one of your veins, into your upper arm, into the head and neck area, or into the space around the spinal nerves in your lower back.

Precautions

It is very important that your doctor check your progress closely while you are receiving this medicine to make sure this medicine is working properly. Blood tests may be needed to check for unwanted effects.

This medicine may cause a rare, but serious blood problem called methemoglobinemia. The risk may be increased in children younger than 6 months of age, elderly patients, or patients with certain inborn defects. It is more likely to occur in patients receiving too much of the medicine, but can also occur with small amounts. Check with your doctor right away if you or your child has the following symptoms after receiving this medicine: pale, gray, or blue-colored skin, lips, or nails, confusion, headache, lightheadedness, fast heartbeat, or unusual tiredness or weakness.

If you receive this medicine into your lower back (epidural), you may experience temporary loss of sensation and movement, usually in the lower half of your body. Talk with your doctor if you have concerns.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

More common

  1. Blurred vision
  2. chest pain or discomfort
  3. confusion
  4. dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  5. lightheadedness, dizziness, or fainting
  6. slow or irregular heartbeat
  7. sweating
  8. unusual tiredness or weakness

Less common

  1. Burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  2. chills
  3. decrease in frequency or amount of urine
  4. difficulty in passing urine (dribbling)
  5. fever
  6. painful urination

Rare

  1. Absence of or decrease in body movement
  2. agitation
  3. anxiety
  4. bluish color of the skin or changes in skin color
  5. changes in vision
  6. clumsiness
  7. continuing ringing or buzzing or other unexplained noise in the ears
  8. cough
  9. decreased awareness or responsiveness
  10. difficulty breathing
  11. drooping upper eyelids
  12. drowsiness
  13. fast or irregular heartbeat
  14. general feeling of discomfort or illness
  15. hearing loss
  16. loss of appetite
  17. loss of consciousness
  18. low body temperature
  19. mood or mental changes
  20. muscle aches
  21. muscle spasms (tetany) or twitching seizures
  22. muscle weakness
  23. nausea
  24. nervousness
  25. noisy breathing
  26. pain or discomfort in the arms, jaw, back, or neck
  27. pain, redness, or swelling in the arm or leg
  28. problems with memory
  29. seeing or hearing things that are not there
  30. seizures
  31. severe sleepiness
  32. severe, unusual tiredness or weakness
  33. shivering
  34. slow heartbeat
  35. swelling of the foot or leg tenderness
  36. tightness in the chest
  37. trembling
  38. trouble sleeping
  39. vomiting
  40. weak or feeble pulse
  41. weight gain
  42. yellow skin or eyes

Incidence not known

  1. Anxiety
  2. depression
  3. difficulty swallowing
  4. excitation
  5. fast, irregular, pounding, or racing heartbeat or pulse
  6. hives, itching, skin rash
  7. inability to breathe without assistance
  8. paralysis of the arms
  9. puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  10. restlessness
  11. slow heartbeat
  12. tremors

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  1. Headache

Less common

  1. Anxiety
  2. runny or stuffy nose
  3. sneezing

Rare

  1. Bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site
  2. difficulty in moving
  3. frequent urge to defecate
  4. joint pain or swelling
  5. lack or loss of strength
  6. loss of bowel control
  7. muscle pain, cramps, or stiffness
  8. straining while passing stool

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Portions of this document last updated: April 01, 2024

Original article: https://www.mayoclinic.org/drugs-supplements/ropivacaine-injection-route/description/drg-20065875