Proper Use

Drug information provided by: Merative, Micromedex®

A nurse or other trained health professional will give you this medicine. It is given through a needle placed into one of your veins or as a shot under your skin, usually in the stomach, thighs, or upper arms.

You or your caregiver may be trained to prepare and inject the medicine at home. Be sure that you understand how to use the medicine. Do not use more medicine or use it more often than your doctor tells you to.

This medicine comes with a Medication Guide and patient instructions. Read and follow these instructions carefully. Ask your doctor if you have any questions.

Risankizumab-rzaa comes in 4 forms: a prefilled pen, a prefilled syringe, a prefilled cartridge with on-body injector, and a vial. Your doctor will tell you which dosage form you should use. The vial is given by a nurse or other trained health professional.

Allow the medicine to warm to room temperature for 30 to 90 minutes for the prefilled pen,15 to 30 minutes for the prefilled syringe, and 45 to 90 minutes for the prefilled cartridge with on-body injector, without removing the medicine from the carton, before you use it. Do not warm the medicine in any other way.

To use the prefilled pen, prefilled syringe, or prefilled cartridge with on-body injector:

  • You will be shown the body areas where this shot can be given. Use a different body area each time you give yourself a shot. Keep track of where you give each shot to make sure you rotate body areas. This will help prevent skin problems from the injections. Do not inject into areas where the skin is tender, bruised, red, hard, thick, scaly, or in areas with scars, stretch marks, or is affected by psoriasis.
  • Check the liquid in the prefilled pen, syringe, or cartridge. It should be clear and colorless to yellow or slightly yellow and may contain small particles. Do not use the medicine if it is cloudy, discolored, or has flakes or large particles in it. Do not shake.
  • Use a new needle and pen, syringe, or cartridge each time you inject your medicine. You might not use all of the medicine in each prefilled pen, syringe, or cartridge. Use each medicine only one time. Do not save an open medicine.
  • Do not use the pen, syringe, or cartridge if it has been dropped or damaged. Do not remove the needle cover until you are ready to use it.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For injectable dosage form (prefilled pen, prefilled syringe, or prefilled cartridge with on-body injector):
    • For moderate to severe active Crohn's disease:
      • Adults—At first, a nurse or other trained health professional will give you this medicine through a needle placed into one of your veins at Weeks 0, 4, and 8. Then, one 180 or 360 milligrams (mg) prefilled cartridge with on-body injector injected under your skin at different body areas at Week 12 and every 8 weeks after.
      • Children—Use and dose must be determined by your doctor.
    • For moderate to severe plaque psoriasis and active psoriatic arthritis:
      • Adults—150 mg prefilled pen or syringe injected under your skin at different body areas at Weeks 0 and 4, and every 12 weeks after.
      • Children—Use and dose must be determined by your doctor.

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Store in the refrigerator. Do not freeze.

Keep the medicine in its original carton until you are ready to use it. Protect from light. Do not use the medicine if it has been frozen, even if it has been thawed.

Throw away used needles in a hard, closed container that the needles cannot poke through. Keep this container away from children and pets.

Portions of this document last updated: April 01, 2024

Copyright: © Merative US L.P. 1973, 2024. All rights reserved. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes.