Precautions

Drug information provided by: IBM Micromedex

It is very important that your doctor check your progress at regular visits to make sure this medicine is working properly. Blood tests may be needed to check for unwanted effects.

Using this medicine while you are pregnant can harm your unborn baby. If you are a woman who can bear children, your doctor may give you a pregnancy test before you start using this medicine to make sure you are not pregnant. Female patients should use an effective form of birth control during treatment with this medicine and for at least 1 week after the last dose. Male patients who have female partners should use effective birth control during treatment with this medicine and for at least 1 week after the last dose. If you think you have become pregnant while using the medicine, tell your doctor right away.

Ripretinib may cause a serious skin problem called hand-foot syndrome or palmar-plantar erythrodysesthesia syndrome. Tell your doctor right away if you have a rash that does not go away or redness, pain, swelling, bleeding, or blisters on the palms of your hands or soles of your feet.

This medicine may increase your risk for new skin cancers (eg, cutaneous squamous cell carcinoma, melanoma). Check with your doctor right away if you have a new wart, skin sore or reddish bump that bleeds or does not heal, or change in size or color of a mole.

Your blood pressure might get too high while you are using this medicine. This may cause headaches, dizziness, or blurred vision. If you think your blood pressure is too high, call your doctor right away.

Check with your doctor right away if you have chest pain or discomfort, dilated neck veins, irregular breathing, irregular heartbeat, swelling of the face, fingers, feet, or lower legs, unusual tiredness or weakness, or weight gain. These could be symptoms of a heart problem (eg, cardiac failure, acute left ventricular failure, diastolic dysfunction, ventricular hypertrophy).

This medicine may affect the way your body heals from cuts and wounds. Make sure any doctor who treats you knows that you are using this medicine. You may need to stop using this medicine several days before and after having surgery.

If you plan to have children, talk with your doctor before using this medicine. Some men using this medicine have become infertile (unable to have children).

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.