Before Using

Drug information provided by: Merative, Micromedex®

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of Propofol-Lipuro 1% injection to sedate children older than 16 years of age with coronavirus disease (COVID-19) in the ICU.

Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of Diprivan® injection to induce anesthesia in children 3 years of age and older, and to maintain anesthesia in children 2 months of age and older. Use of this medicine to induce anesthesia in children younger than 3 years of age and to maintain anesthesia in children younger than 2 months of age is not recommended. Safety and efficacy have not been established in children for other approved conditions.

Serious unwanted effects on early brain development of children younger than 3 years of age may occur with repeated or prolonged use of this medicine. Talk to your doctor if you have concerns about this.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of propofol injection in the elderly. However, elderly patients are more likely to have age-related heart or lung disease (eg, low blood pressure, breathing problems), which may require caution and an adjustment in the dose for patients receiving this medicine.

Breastfeeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Drug Interactions

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Alprazolam
  • Amobarbital
  • Barbital
  • Benzhydrocodone
  • Bromazepam
  • Bromopride
  • Bupivacaine
  • Bupivacaine Liposome
  • Buprenorphine
  • Bupropion
  • Butabarbital
  • Butorphanol
  • Calcium Oxybate
  • Cannabidiol
  • Cannabis
  • Carbinoxamine
  • Cetirizine
  • Chloral Hydrate
  • Chlordiazepoxide
  • Clobazam
  • Clonazepam
  • Clorazepate
  • Codeine
  • Daridorexant
  • Dexmedetomidine
  • Diazepam
  • Dichloralphenazone
  • Dihydrocodeine
  • Doxylamine
  • Esketamine
  • Estazolam
  • Eszopiclone
  • Fentanyl
  • Flibanserin
  • Gabapentin
  • Gabapentin Enacarbil
  • Hexobarbital
  • Hydrocodone
  • Hydromorphone
  • Ketamine
  • Lacosamide
  • Lemborexant
  • Levocetirizine
  • Levorphanol
  • Lidocaine
  • Lofexidine
  • Lorazepam
  • Loxapine
  • Magnesium Oxybate
  • Meclizine
  • Meperidine
  • Mephobarbital
  • Meprobamate
  • Methadone
  • Metoclopramide
  • Midazolam
  • Morphine
  • Morphine Sulfate Liposome
  • Nalbuphine
  • Olanzapine
  • Oxazepam
  • Oxycodone
  • Oxymorphone
  • Paraldehyde
  • Pentazocine
  • Periciazine
  • Phenobarbital
  • Potassium Oxybate
  • Prazepam
  • Pregabalin
  • Primidone
  • Ramelteon
  • Remifentanil
  • Remimazolam
  • Ropeginterferon Alfa-2b-njft
  • Scopolamine
  • Secobarbital
  • Sodium Oxybate
  • St John's Wort
  • Sufentanil
  • Tapentadol
  • Temazepam
  • Topiramate
  • Tramadol
  • Trazodone
  • Triazolam
  • Valproic Acid
  • Zaleplon
  • Zolpidem
  • Zopiclone
  • Zuranolone

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Alfentanil
  • Succinylcholine

Other Interactions

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Allergy to eggs, egg products, soybeans, or soy products, history of—Should not be used in patients with this condition.
  • Brain or nerve problems (eg, head injury, stroke, or seizures), history of or
  • Diabetes or
  • High fat or cholesterol in the blood or
  • Infection (eg, sepsis), severe or
  • Pancreatitis (swelling of the pancreas)—Use with caution. May increase risk for more serious side effects.
  • Heart disease or
  • Kidney disease or
  • Lung or breathing problems or
  • Mitochondrial disorder (genetic disorder) or
  • Seizures—Use with caution. May make these conditions worse.