Before Using

Drug information provided by: Merative, Micromedex®

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Although there is no specific information about the use of procarbazine in children, it is not expected to cause different side effects or problems in children than it does in adults.

Geriatric

Side effects may be more likely to occur in elderly patients, who are usually more sensitive to the effects of procarbazine.

Breastfeeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Drug Interactions

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

  • Amitriptyline
  • Amphetamine
  • Apraclonidine
  • Atomoxetine
  • Benzphetamine
  • Brimonidine
  • Bupropion
  • Carbamazepine
  • Carbidopa
  • Carbinoxamine
  • Citalopram
  • Clomipramine
  • Codeine
  • Cyclobenzaprine
  • Cyproheptadine
  • Desipramine
  • Desvenlafaxine
  • Deutetrabenazine
  • Dexfenfluramine
  • Dexmethylphenidate
  • Dextroamphetamine
  • Dextromethorphan
  • Diethylpropion
  • Doxylamine
  • Duloxetine
  • Entacapone
  • Escitalopram
  • Fenfluramine
  • Fluoxetine
  • Fluvoxamine
  • Gepirone
  • Guanadrel
  • Guanethidine
  • Hydroxytryptophan
  • Imipramine
  • Isocarboxazid
  • Isometheptene
  • Levodopa
  • Levomethadyl
  • Levomilnacipran
  • Linezolid
  • Lisdexamfetamine
  • Maprotiline
  • Mazindol
  • Measles Virus Vaccine, Live
  • Meperidine
  • Methamphetamine
  • Methyldopa
  • Methylphenidate
  • Milnacipran
  • Mirtazapine
  • Mumps Virus Vaccine, Live
  • Nefopam
  • Nortriptyline
  • Opipramol
  • Ozanimod
  • Paroxetine
  • Phendimetrazine
  • Phenelzine
  • Phenmetrazine
  • Phentermine
  • Phenylalanine
  • Phenylephrine
  • Phenylpropanolamine
  • Pseudoephedrine
  • Rasagiline
  • Reserpine
  • Rizatriptan
  • Rotavirus Vaccine, Live
  • Rubella Virus Vaccine, Live
  • Safinamide
  • Selegiline
  • Serdexmethylphenidate
  • Sertraline
  • Sibutramine
  • Solriamfetol
  • Sumatriptan
  • Tapentadol
  • Tetrabenazine
  • Tramadol
  • Tranylcypromine
  • Trazodone
  • Trimipramine
  • Tryptophan
  • Varicella Virus Vaccine, Live
  • Venlafaxine
  • Vilazodone
  • Viloxazine
  • Vortioxetine
  • Zolmitriptan
  • Zoster Vaccine, Live

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Acetophenazine
  • Adenovirus Vaccine, Live
  • Albuterol
  • Alfentanil
  • Amobarbital
  • Amoxapine
  • Aprobarbital
  • Atropine
  • Bacillus of Calmette and Guerin Vaccine, Live
  • Barbital
  • Benzhydrocodone
  • Buprenorphine
  • Buspirone
  • Butabarbital
  • Butalbital
  • Butorphanol
  • Chlorpromazine
  • Cholera Vaccine, Live
  • Clovoxamine
  • Dengue Tetravalent Vaccine, Live
  • Difenoxin
  • Dihydrocodeine
  • Diphenoxylate
  • Dixyrazine
  • Dolasetron
  • Dothiepin
  • Doxepin
  • Droperidol
  • Ebola Zaire Vaccine, Live
  • Epinephrine
  • Eterobarb
  • Ethchlorvynol
  • Ethopropazine
  • Femoxetine
  • Fentanyl
  • Fluphenazine
  • Formoterol
  • Frovatriptan
  • Granisetron
  • Guarana
  • Heptabarbital
  • Hexobarbital
  • Hydrocodone
  • Hydromorphone
  • Influenza Virus Vaccine, Live
  • Iobenguane I 123
  • Iobenguane I 131
  • Kava
  • Lasmiditan
  • Levorphanol
  • Licorice
  • Lithium
  • Lofepramine
  • Lorcaserin
  • Ma Huang
  • Mate
  • Mephobarbital
  • Mesoridazine
  • Metaxalone
  • Methadone
  • Methohexital
  • Methotrimeprazine
  • Methylene Blue
  • Metoclopramide
  • Midodrine
  • Morphine
  • Morphine Sulfate Liposome
  • Nalbuphine
  • Naratriptan
  • Nefazodone
  • Norepinephrine
  • Oliceridine
  • Ondansetron
  • Oxycodone
  • Oxymetazoline
  • Oxymorphone
  • Palonosetron
  • Pentazocine
  • Pentobarbital
  • Perazine
  • Periciazine
  • Perphenazine
  • Phenobarbital
  • Pipotiazine
  • Poliovirus Vaccine, Live
  • Primidone
  • Prochlorperazine
  • Promazine
  • Promethazine
  • Propiomazine
  • Protriptyline
  • Reboxetine
  • Remifentanil
  • Secobarbital
  • Smallpox Monkeypox Vaccine, Live Non-Replicating
  • Smallpox Vaccine
  • St John's Wort
  • Sufentanil
  • Thiethylperazine
  • Thiopental
  • Thioridazine
  • Tolcapone
  • Trifluoperazine
  • Triflupromazine
  • Typhoid Vaccine, Live
  • Tyrosine
  • Valbenazine
  • Vilanterol
  • Warfarin
  • Yellow Fever Vaccine
  • Ziprasidone

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Acarbose
  • Chlorpropamide
  • Ginseng
  • Glimepiride
  • Glipizide
  • Glyburide
  • Insulin
  • Insulin Aspart, Recombinant
  • Insulin Bovine
  • Insulin Degludec
  • Insulin Detemir
  • Insulin Glargine, Recombinant
  • Insulin Glulisine
  • Insulin Lispro, Recombinant
  • Metformin
  • Methotrexate
  • Nateglinide
  • Repaglinide
  • Tolazamide
  • Tolbutamide

Other Interactions

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following is usually not recommended, but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.

  • Avocado
  • Bitter Orange
  • Ethanol

Using this medicine with any of the following may cause an increased risk of certain side effects but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.

  • Tyramine Containing Food

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Alcoholism
  • Angina (chest pain) or
  • Heart or blood vessel disease or
  • Heart attack or stroke (recent)—Lowered blood pressure caused by procarbazine may make problems associated with some of these conditions worse
  • Chickenpox (including recent exposure) or
  • Herpes zoster (shingles)—Risk of severe disease affecting other parts of the body
  • Type 2 diabetes mellitus—Procarbazine may change the amount of diabetes medicine needed
  • Epilepsy—Procarbazine may change the seizures
  • Headaches (severe or frequent)—You may not realize when a severe headache is caused by a dangerous reaction to procarbazine
  • Infection—Procarbazine can reduce immunity to infection
  • Kidney disease—Effects may be increased because of slower removal of procarbazine from the body
  • Liver disease—Procarbazine can cause severe liver disease to become much worse
  • Mental illness (or history of)—Some cases of mental illness may be worsened
  • Overactive thyroid—Increased risk of dangerous reaction to procarbazine
  • Parkinson's disease—May be worsened
  • Pheochromocytoma—Blood pressure may be affected

Portions of this document last updated: June 01, 2024

Copyright: © Merative US L.P. 1973, 2024. All rights reserved. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes.