Description and Brand Names

Drug information provided by: Merative, Micromedex®

US Brand Name

  1. K-Phos Neutral
  2. Phospha 250 Neutral

Descriptions


Phospha 250™ Neutral contains potassium phosphate and sodium phosphate. It is a phosphate supplement that is used to increase the amount of phosphate in the blood.

This medicine is available only with your doctor's prescription.

This product is available in the following dosage forms:

  • Tablet

Before Using

If you are taking this dietary supplement without a prescription, carefully read and follow any precautions on the label. For this supplement, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of Phospha 250™ Neutral in children 4 years of age and older. However, safety and efficacy of have not been established in children younger than 4 years of age.

Geriatric

No information is available on the relationship of age to the effects of Phospha 250™ Neutral in geriatric patients.

Breastfeeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Drug Interactions

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this dietary supplement, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this dietary supplement with any of the following medicines is not recommended. Your doctor may decide not to treat you with this dietary supplement or change some of the other medicines you take.

  • Bepridil
  • Burosumab-twza
  • Cisapride
  • Dronedarone
  • Levoketoconazole
  • Mesoridazine
  • Pimozide
  • Piperaquine
  • Saquinavir
  • Sparfloxacin
  • Terfenadine
  • Thioridazine
  • Ziprasidone

Using this dietary supplement with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Adagrasib
  • Alfuzosin
  • Amiloride
  • Amiodarone
  • Amisulpride
  • Amitriptyline
  • Amoxapine
  • Anagrelide
  • Apomorphine
  • Aripiprazole
  • Aripiprazole Lauroxil
  • Arsenic Trioxide
  • Asenapine
  • Astemizole
  • Atazanavir
  • Azilsartan
  • Azilsartan Medoxomil
  • Azithromycin
  • Bedaquiline
  • Buprenorphine
  • Buserelin
  • Candesartan
  • Canrenoate
  • Canrenone
  • Ceritinib
  • Chloroquine
  • Chlorpromazine
  • Cilazapril
  • Ciprofloxacin
  • Citalopram
  • Clarithromycin
  • Clofazimine
  • Clomipramine
  • Clothiapine
  • Clozapine
  • Crizotinib
  • Cyclosporine
  • Dabrafenib
  • Dasatinib
  • Degarelix
  • Delamanid
  • Desipramine
  • Deslorelin
  • Deutetrabenazine
  • Dexmedetomidine
  • Digoxin
  • Disopyramide
  • Dofetilide
  • Dolasetron
  • Domperidone
  • Donepezil
  • Droperidol
  • Efavirenz
  • Enalapril
  • Enalaprilat
  • Encorafenib
  • Entrectinib
  • Eplerenone
  • Eprosartan
  • Erdafitinib
  • Erythromycin
  • Escitalopram
  • Etrasimod
  • Fexinidazole
  • Fingolimod
  • Flecainide
  • Fluconazole
  • Fluoxetine
  • Formoterol
  • Foscarnet
  • Fosinopril
  • Fostemsavir
  • Gatifloxacin
  • Gemifloxacin
  • Gepirone
  • Glasdegib
  • Gonadorelin
  • Goserelin
  • Granisetron
  • Halofantrine
  • Haloperidol
  • Histrelin
  • Hydroxychloroquine
  • Hydroxyzine
  • Ibutilide
  • Iloperidone
  • Imipramine
  • Inotuzumab Ozogamicin
  • Irbesartan
  • Ivabradine
  • Ivosidenib
  • Ketoconazole
  • Lapatinib
  • Lefamulin
  • Lenvatinib
  • Leuprolide
  • Levofloxacin
  • Lisinopril
  • Lofexidine
  • Lopinavir
  • Losartan
  • Lumefantrine
  • Macimorelin
  • Mefloquine
  • Methadone
  • Metronidazole
  • Mifepristone
  • Mirtazapine
  • Mobocertinib
  • Moexipril
  • Moxifloxacin
  • Nafarelin
  • Nilotinib
  • Norfloxacin
  • Nortriptyline
  • Octreotide
  • Ofloxacin
  • Olanzapine
  • Olmesartan
  • Ondansetron
  • Osilodrostat
  • Osimertinib
  • Oxaliplatin
  • Ozanimod
  • Pacritinib
  • Paliperidone
  • Panobinostat
  • Paroxetine
  • Pasireotide
  • Pazopanib
  • Perindopril
  • Phenobarbital
  • Pimavanserin
  • Pitolisant
  • Ponesimod
  • Posaconazole
  • Primidone
  • Procainamide
  • Prochlorperazine
  • Promethazine
  • Propafenone
  • Protriptyline
  • Quetiapine
  • Quinapril
  • Quinidine
  • Quinine
  • Quizartinib
  • Ramipril
  • Ranolazine
  • Relugolix
  • Ribociclib
  • Selpercatinib
  • Sertraline
  • Sevoflurane
  • Siponimod
  • Solifenacin
  • Sorafenib
  • Sotalol
  • Spirapril
  • Spironolactone
  • Sulpiride
  • Sunitinib
  • Tacrolimus
  • Telavancin
  • Telithromycin
  • Telmisartan
  • Tetrabenazine
  • Trandolapril
  • Trazodone
  • Triamterene
  • Triclabendazole
  • Trimipramine
  • Triptorelin
  • Valsartan
  • Vandetanib
  • Vardenafil
  • Vemurafenib
  • Venlafaxine
  • Vilanterol
  • Vinflunine
  • Voclosporin
  • Voriconazole
  • Zofenopril
  • Zuclopenthixol

Using this dietary supplement with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Aluminum Carbonate, Basic
  • Aluminum Hydroxide
  • Aluminum Phosphate
  • Calcium Acetate
  • Calcium Carbonate
  • Calcium Citrate
  • Dihydroxyaluminum Aminoacetate
  • Dihydroxyaluminum Sodium Carbonate
  • Magaldrate
  • Magnesium Carbonate
  • Magnesium Hydroxide
  • Magnesium Oxide
  • Magnesium Trisilicate

Other Interactions

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this dietary supplement. Make sure you tell your doctor if you have any other medical problems, especially:

  • Addison's disease (an adrenal problem) or
  • Dehydration or
  • Heart disease or
  • Heart failure or
  • Hypercalcemia (high calcium in the blood) or
  • Hyperkalemia (high potassium in the blood) or
  • Hypernatremia (high sodium in the blood) or
  • Hypertension (high blood pressure) or
  • Hypoparathyroidism (underactive parathyroid gland) or
  • Liver disease (eg, cirrhosis), severe or
  • Myotonia congenita (an inherited muscle disease) or
  • Pancreatitis (inflammation of the pancreas) or
  • Pulmonary edema (fluid in the lungs) or
  • Rickets (bone problem caused by too little vitamin D) or
  • Severe burns on the skin—Use with caution. May make these conditions worse.
  • Hyperphosphatemia (too much phosphorus in the blood) or
  • Kidney problem, severe or
  • Phosphate stones, infected—Should not be used in patients with these conditions.

Proper Use

Take this medicine exactly as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered.

Take the tablet with a full (8 ounce) glass of water. Take it with meals and at bedtime, unless your doctor tells you differently.

If you are taking aluminum, magnesium, or calcium-containing antacids, do not take them at the same time that you take this medicine. This may keep the phosphate supplement from working properly.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For oral dosage form (tablets):
    • For phosphate supplement:
      • Adults—One or two tablets four times a day.
      • Teenagers and children 4 years of age and older—One tablet four times a day.
      • Children younger than 4 years of age—Use and dose must be determined by your doctor.

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Precautions

It is very important that your doctor check your progress at regular visits. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to take it. Blood tests may be needed to check for unwanted effects.

If you already have kidney stones, you may pass old stones when you begin using the medicine.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Incidence not known

  1. Bone pain
  2. convulsions
  3. decreased urine output
  4. dizziness
  5. fast or irregular heartbeat
  6. headache
  7. joint pain
  8. mental confusion
  9. muscle cramps
  10. numbness or tingling around the lips
  11. numbness, tingling, pain, or weakness of the hands or feet
  12. shortness of breath
  13. swelling of the feet or lower legs
  14. troubled breathing
  15. unusual thirst
  16. unusual tiredness or weakness
  17. unusual weight gain
  18. weakness or heaviness of the legs

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence not known

  1. Diarrhea
  2. nausea
  3. stomach pain
  4. vomiting

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Portions of this document last updated: April 01, 2024

Original article: https://www.mayoclinic.org/drugs-supplements/potassium-and-sodium-phosphate-oral-route/precautions/drg-20074868