Before Using

Drug information provided by: IBM Micromedex

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Geriatric

Many medicines have not been studied specifically in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults or if they cause different side effects or problems in older people. Although there is no specific information comparing the use of papaverine for erectile dysfunction in the elderly with use in other age groups, this medicine is not expected to cause different side effects or problems in older people than it does in younger adults.

Breastfeeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Drug Interactions

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

  • Bepridil
  • Cisapride
  • Dronedarone
  • Piperaquine
  • Riociguat
  • Terfenadine

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Amiodarone
  • Amisulpride
  • Apomorphine
  • Aripiprazole Lauroxil
  • Ceritinib
  • Chloroquine
  • Clofazimine
  • Clozapine
  • Crizotinib
  • Dabrafenib
  • Dasatinib
  • Deutetrabenazine
  • Efavirenz
  • Encorafenib
  • Entrectinib
  • Fingolimod
  • Fluconazole
  • Formoterol
  • Foscarnet
  • Fostemsavir
  • Glasdegib
  • Hydroxychloroquine
  • Hydroxyzine
  • Inotuzumab Ozogamicin
  • Ivosidenib
  • Ketoconazole
  • Lefamulin
  • Lenvatinib
  • Leuprolide
  • Lofexidine
  • Macimorelin
  • Methadone
  • Metronidazole
  • Mirtazapine
  • Mobocertinib
  • Nilotinib
  • Osilodrostat
  • Osimertinib
  • Oxaliplatin
  • Ozanimod
  • Pimavanserin
  • Pitolisant
  • Ponesimod
  • Posaconazole
  • Quetiapine
  • Ribociclib
  • Selpercatinib
  • Sertraline
  • Siponimod
  • Solifenacin
  • Sotalol
  • Sulpiride
  • Sunitinib
  • Tacrolimus
  • Trazodone
  • Triclabendazole
  • Vemurafenib
  • Vinflunine
  • Voclosporin
  • Zuclopenthixol

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Ginkgo

Other Interactions

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Bleeding problems—These conditions increase the risk of bleeding at the place of injection.
  • Liver disease—Papaverine can cause liver damage when it is given in ways that allow it to get into the bloodstream (by mouth or by injection into a muscle, a vein, or an artery); when papaverine is given by intracavernosal injection, liver damage is much less likely because the medicine enters the bloodstream very slowly.
  • Priapism (history of) or
  • Sickle cell disease—Patients with these conditions have an increased risk of priapism (erection lasting longer than 4 hours) while using papaverine.

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