Proper Use

Drug information provided by: Merative, Micromedex®

Take this medicine exactly as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered.

This medicine should come with a Medication Guide. Read and follow the instructions carefully. Ask your doctor or pharmacist if you have any questions. Ask your pharmacist for the medication guide if you do not have one.

You may take this medicine with or without food. Swallow the tablet whole. Do not crush, break, or chew it.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For oral dosage forms (tablets):
    • For treatment of schizophrenia:
      • Adults—At first, 5 to 10 milligrams (mg) olanzapine and 10 mg samidorphan once a day. Your doctor may adjust your dose if needed. However, the dose is usually not more than 20 mg olanzapine and 10 mg samidorphan per day.
      • Children—Use and dose must be determined by your doctor.
    • For treatment of mania or mixed episodes with bipolar disorder (olanzapine/samidorphan alone):
      • Adults—At first, 10 to 15 milligrams (mg) olanzapine and 10 mg samidorphan once a day. Your doctor may adjust your dose if needed. However, the dose is usually not more than 20 mg olanzapine and 10 mg samidorphan per day.
      • Children---Use and dose must be determined by your doctor.
    • For treatment of mania or mixed episodes with bipolar disorder (olanzapine/samidorphan with lithium or valproate):
      • Adults—At first, 10 milligrams (mg) olanzapine and 10 mg samidorphan once a day. Your doctor may adjust your dose if needed. However, the dose is usually not more than 20 mg olanzapine and 10 mg samidorphan per day.
      • Children—Use and dose must be determined by your doctor.

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.