Before Using
Drug information provided by: Merative, Micromedex®
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:
Allergies
Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Pediatric
Appropriate studies have not been performed on the relationship of age to the effects of olanzapine and samidorphan combination in the pediatric population. Safety and efficacy have not been established.
Geriatric
Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of olanzapine and samidorphan combination in the elderly. However, elderly patients are more likely to have serious unwanted effects, which may require caution and an adjustment in the dose for patients receiving this medicine.
Breastfeeding
There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.
Drug Interactions
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.
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Alfentanil
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Anileridine
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Benzhydrocodone
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Bepridil
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Bromopride
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Buprenorphine
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Butorphanol
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Cisapride
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Codeine
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Diacetylmorphine
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Difenoxin
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Dihydrocodeine
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Diphenoxylate
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Dronedarone
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Ethylmorphine
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Fentanyl
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Hydrocodone
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Hydromorphone
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Ketobemidone
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Levoketoconazole
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Levomethadyl
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Levorphanol
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Meperidine
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Methadone
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Metoclopramide
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Morphine
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Morphine Sulfate Liposome
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Nalbuphine
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Nicomorphine
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Opium
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Opium Alkaloids
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Oxycodone
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Oxymorphone
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Papaveretum
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Paregoric
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Pimozide
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Piperaquine
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Piritramide
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Potassium Citrate
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Remifentanil
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Saquinavir
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Sparfloxacin
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Sufentanil
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Tapentadol
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Terfenadine
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Thioridazine
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Tilidine
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Tramadol
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Ziprasidone
Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
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Abametapir
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Acepromazine
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Aclidinium
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Adagrasib
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Alfentanil
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Alfuzosin
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Alprazolam
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Amantadine
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Amiodarone
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Amisulpride
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Amitriptyline
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Amobarbital
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Amoxapine
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Anagrelide
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Anileridine
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Apalutamide
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Apomorphine
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Apomorphine Hydrochloride
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Aripiprazole
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Aripiprazole Lauroxil
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Arsenic Trioxide
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Asenapine
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Astemizole
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Atazanavir
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Atropine
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Avacopan
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Azithromycin
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Baclofen
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Bedaquiline
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Belladonna
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Benperidol
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Benzhydrocodone
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Benztropine
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Biperiden
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Bromazepam
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Bromocriptine Mesylate
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Brompheniramine
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Buprenorphine
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Bupropion
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Buserelin
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Buspirone
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Butabarbital
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Butalbital
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Butorphanol
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Cabergoline
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Calcium Oxybate
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Cannabidiol
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Cannabis
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Capmatinib
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Carbamazepine
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Carbinoxamine
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Carisoprodol
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Carphenazine
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Ceritinib
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Cetirizine
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Chloral Hydrate
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Chlordiazepoxide
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Chloroquine
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Chlorpheniramine
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Chlorpromazine
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Chlorzoxazone
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Ciprofloxacin
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Citalopram
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Clarithromycin
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Clemastine
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Clidinium
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Clobazam
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Clofazimine
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Clomipramine
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Clonazepam
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Clorazepate
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Clothiapine
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Clozapine
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Cobicistat
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Codeine
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Crizotinib
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Cyclobenzaprine
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Cyclopentolate
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Cyproheptadine
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Dabrafenib
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Daridorexant
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Darifenacin
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Dasatinib
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Degarelix
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Delamanid
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Desipramine
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Deslorelin
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Deutetrabenazine
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Dexmedetomidine
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Diacetylmorphine
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Diazepam
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Dichloralphenazone
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Dicyclomine
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Difenoxin
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Dihydrocodeine
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Dimenhydrinate
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Diphenhydramine
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Diphenoxylate
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Disopyramide
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Dofetilide
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Dolasetron
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Domperidone
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Donepezil
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Doxepin
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Doxylamine
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Droperidol
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Ebastine
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Efavirenz
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Encorafenib
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Enflurane
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Enoxacin
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Entrectinib
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Enzalutamide
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Eribulin
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Erythromycin
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Escitalopram
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Esketamine
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Estazolam
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Eszopiclone
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Ethchlorvynol
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Ethopropazine
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Ethylmorphine
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Etrasimod
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Famotidine
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Fedratinib
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Felbamate
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Fenoldopam Mesylate
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Fentanyl
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Fesoterodine
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Fexinidazole
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Fingolimod
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Flavoxate
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Flecainide
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Flibanserin
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Fluconazole
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Flunitrazepam
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Fluoxetine
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Fluphenazine
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Flurazepam
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Fluspirilene
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Fluvoxamine
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Formoterol
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Foscarnet
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Fosphenytoin
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Fospropofol
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Fostemsavir
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Gabapentin
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Gabapentin Enacarbil
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Galantamine
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Gatifloxacin
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Gemifloxacin
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Gepirone
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Givinostat
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Glasdegib
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Glucagon
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Glycopyrrolate
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Glycopyrronium Tosylate
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Gonadorelin
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Goserelin
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Granisetron
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Halazepam
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Halofantrine
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Haloperidol
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Halothane
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Hexobarbital
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Histrelin
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Homatropine
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Hydrocodone
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Hydromorphone
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Hydroquinidine
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Hydroxychloroquine
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Hydroxyzine
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Hyoscyamine
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Ibutilide
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Iloperidone
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Imipramine
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Inotuzumab Ozogamicin
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Ipratropium
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Isoflurane
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Itraconazole
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Ivabradine
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Ivosidenib
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Ketamine
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Ketazolam
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Ketobemidone
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Ketoconazole
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Lacosamide
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Lapatinib
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Lefamulin
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Lemborexant
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Lenvatinib
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LetibotulinumtoxinA-wlbg
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Leuprolide
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Levocetirizine
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Levodopa
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Levofloxacin
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Levorphanol
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Lithium
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Lofexidine
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Lonafarnib
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Loxapine
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Lumacaftor
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Lumefantrine
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Macimorelin
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Magnesium Oxybate
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Mavacamten
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Mavorixafor
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Meclizine
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Mefloquine
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Melperone
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Mepenzolate
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Meperidine
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Mephobarbital
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Meprobamate
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Meptazinol
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Mesoridazine
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Metaxalone
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Methacholine
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Methadone
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Methdilazine
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Methocarbamol
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Methohexital
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Methotrimeprazine
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Methylene Blue
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Metronidazole
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Mifepristone
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Mirtazapine
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Mitotane
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Mizolastine
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Mobocertinib
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Molindone
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Montelukast
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Moricizine
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Morphine
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Morphine Sulfate Liposome
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Moxifloxacin
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Nafarelin
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Nalbuphine
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Naldemedine
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Naloxegol
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Nelfinavir
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Nicomorphine
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Nilotinib
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Nitrazepam
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Nitrous Oxide
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Norfloxacin
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Nortriptyline
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Octreotide
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Ofloxacin
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Oliceridine
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Omaveloxolone
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Omeprazole
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Ondansetron
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Opium
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Opium Alkaloids
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Orphenadrine
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Osilodrostat
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Osimertinib
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Oxaliplatin
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Oxazepam
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Oxitropium Bromide
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Oxybutynin
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Oxycodone
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Oxymorphone
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Ozanimod
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Pacritinib
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Paliperidone
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Panobinostat
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Papaveretum
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Papaverine
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Paregoric
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Paroxetine
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Pasireotide
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Pazopanib
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Pentamidine
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Pentazocine
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Pentobarbital
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Perampanel
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Perazine
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Periciazine
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Perphenazine
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Phenobarbital
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Phenytoin
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Pimavanserin
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Pipamperone
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Pipenzolate Bromide
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Piperacetazine
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Pipotiazine
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Pirenzepine
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Piritramide
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Pitolisant
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Pixantrone
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Ponesimod
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Posaconazole
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Potassium Oxybate
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Pramipexole Dihydrochloride
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Prazepam
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Pregabalin
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Primidone
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Probucol
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Procainamide
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Prochlorperazine
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Procyclidine
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Promazine
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Promethazine
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Propafenone
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Propantheline
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Propiverine
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Propofol
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Protriptyline
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Quazepam
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Quetiapine
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Quinidine
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Quinine
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Quizartinib
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Ramelteon
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Ranolazine
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Relugolix
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Remifentanil
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Remimazolam
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Remoxipride
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Revefenacin
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Ribociclib
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Rifampin
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Rifapentine
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Rilpivirine
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Risperidone
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Ritonavir
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Rofecoxib
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Ropeginterferon Alfa-2b-njft
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Ropinirole Hydrochloride
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Rotigotine
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Scopolamine
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Secobarbital
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Secretin Human
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Selpercatinib
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Sertindole
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Sertraline
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Sevoflurane
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Siponimod
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Sodium Oxybate
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Sodium Phosphate
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Sodium Phosphate, Dibasic
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Sodium Phosphate, Monobasic
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Sofpironium
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Solifenacin
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Sorafenib
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Sotalol
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St John's Wort
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Stramonium
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Sufentanil
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Sulpiride
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Sultopride
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Sunitinib
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Suvorexant
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Tacrolimus
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Tamoxifen
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Tapentadol
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Telaprevir
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Telavancin
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Telithromycin
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Temazepam
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Teriflunomide
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Terodiline
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Tetrabenazine
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Thiethylperazine
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Thiopental
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Thiopropazate
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Thiothixene
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Tilidine
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Tiotropium
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Tizanidine
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Tolonium Chloride
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Tolterodine
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Topiramate
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Toremifene
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Tramadol
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Trazodone
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Triazolam
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Triclabendazole
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Trifluoperazine
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Trifluperidol
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Triflupromazine
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Trihexyphenidyl
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Trimeprazine
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Trimipramine
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Triptorelin
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Tropicamide
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Trospium
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Umeclidinium
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Vandetanib
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Vardenafil
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Vemurafenib
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Venlafaxine
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Vilanterol
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Viloxazine
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Vinflunine
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Voclosporin
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Voriconazole
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Vorinostat
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Zaleplon
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Zolpidem
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Zopiclone
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Zotepine
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Zuclopenthixol
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Zuranolone
Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
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Amprenavir
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Betel Nut
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Fosamprenavir
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Valproic Acid
Other Interactions
Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using this medicine with any of the following is usually not recommended, but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.
Other Medical Problems
The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:
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Alcohol or drug abuse, or dependence, history of or
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Blood or bone marrow problems (eg, leukopenia, neutropenia) or
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Breast cancer, prolactin-dependent or
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Diabetes or
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Dyslipidemia (high cholesterol or fats in the blood) or
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Hyperglycemia (high blood sugar) or
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Hyperprolactinemia (high prolactin in the blood) or
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Prostatic hypertrophy (enlarged prostate), or history of or
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Seizures, history of or
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Stomach or bowel problems (eg, blockage) or
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Trouble swallowing or
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Urinary retention (problems with passing urine), or history of—Use with caution. This medicine may make these conditions worse.
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Blood vessel or circulation problems or
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Dehydration or
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Heart attack or stroke, history of or
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Heart disease or
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Heart failure or
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Heart rhythm problems or
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Hypertension (high blood pressure) or
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Hypotension (low blood pressure) or
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Hypovolemia (low blood volume)—May cause side effects to become worse.
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Kidney disease, severe or
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Liver disease—Use with caution. The effects may be increased because of slower removal of the medicine from the body.
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Opioid (narcotic) medicine withdrawal—Should not be used in patients with this condition.
Portions of this document last updated: Aug. 01, 2024
Copyright: © Merative US L.P. 1973, 2024. All rights reserved. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes.