Description and Brand Names

Drug information provided by: IBM Micromedex

US Brand Name

  1. Mycapssa

Descriptions


Octreotide is used for the long-term treatment of acromegaly (a growth hormone disorder) in patients who have been previously treated with octreotide or lanreotide. This medicine works by reducing the amount of growth hormone that the body produces.

This medicine is available only with your doctor's prescription.

This product is available in the following dosage forms:

  • Capsule, Delayed Release

Before Using

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of octreotide in the pediatric population. Safety and efficacy have not been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of octreotide in the elderly. However, elderly patients are more sensitive to the effects of this medicine than younger adults.

Breastfeeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Drug Interactions

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

  • Bepridil
  • Cisapride
  • Dronedarone
  • Levomethadyl
  • Mesoridazine
  • Pimozide
  • Piperaquine
  • Saquinavir
  • Sparfloxacin
  • Terfenadine
  • Thioridazine
  • Ziprasidone

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Acarbose
  • Acecainide
  • Acetophenazine
  • Ajmaline
  • Albiglutide
  • Alfentanil
  • Alogliptin
  • Aluminum Carbonate, Basic
  • Aluminum Hydroxide
  • Aluminum Phosphate
  • Amiodarone
  • Amisulpride
  • Amitriptyline
  • Amoxapine
  • Anagrelide
  • Apomorphine
  • Aprindine
  • Aripiprazole
  • Aripiprazole Lauroxil
  • Arsenic Trioxide
  • Asenapine
  • Astemizole
  • Azimilide
  • Azithromycin
  • Bretylium
  • Buprenorphine
  • Buserelin
  • Calcium Carbonate
  • Calcium Silicate
  • Canagliflozin
  • Ceritinib
  • Chloral Hydrate
  • Chloroquine
  • Chlorpromazine
  • Chlorpropamide
  • Cimetidine
  • Ciprofloxacin
  • Citalopram
  • Clarithromycin
  • Clofazimine
  • Clomipramine
  • Clozapine
  • Copper Cu 64 Dotatate
  • Crizotinib
  • Cyclosporine
  • Dabrafenib
  • Dapagliflozin
  • Dasatinib
  • Degarelix
  • Delamanid
  • Desipramine
  • Deslorelin
  • Desogestrel
  • Deutetrabenazine
  • Dexlansoprazole
  • Dibenzepin
  • Dienogest
  • Digoxin
  • Dihydroergotamine
  • Dihydroxyaluminum Aminoacetate
  • Dihydroxyaluminum Sodium Carbonate
  • Disopyramide
  • Dofetilide
  • Dolasetron
  • Domperidone
  • Donepezil
  • Doxepin
  • Droperidol
  • Drospirenone
  • Dulaglutide
  • Efavirenz
  • Empagliflozin
  • Encainide
  • Encorafenib
  • Enflurane
  • Entrectinib
  • Ergotamine
  • Ertugliflozin
  • Erythromycin
  • Escitalopram
  • Esomeprazole
  • Estradiol
  • Ethinyl Estradiol
  • Ethopropazine
  • Ethynodiol
  • Exenatide
  • Famotidine
  • Fentanyl
  • Fingolimod
  • Flecainide
  • Flibanserin
  • Fluconazole
  • Fluoxetine
  • Fluphenazine
  • Formoterol
  • Foscarnet
  • Fostemsavir
  • Gallium Ga 68 Dotatate
  • Gallium Ga 68 Dotatoc
  • Gatifloxacin
  • Gemifloxacin
  • Gestodene
  • Glasdegib
  • Glimepiride
  • Glipizide
  • Glyburide
  • Gonadorelin
  • Goserelin
  • Granisetron
  • Halofantrine
  • Haloperidol
  • Halothane
  • Histrelin
  • Hydroquinidine
  • Hydroxychloroquine
  • Hydroxyzine
  • Ibutilide
  • Iloperidone
  • Imipramine
  • Inotuzumab Ozogamicin
  • Insulin
  • Insulin Aspart, Recombinant
  • Insulin Bovine
  • Insulin Degludec
  • Insulin Detemir
  • Insulin Glargine, Recombinant
  • Insulin Glulisine
  • Insulin Lispro, Recombinant
  • Isoflurane
  • Isradipine
  • Ivabradine
  • Ivosidenib
  • Ketoconazole
  • Lansoprazole
  • Lapatinib
  • Lefamulin
  • Lenvatinib
  • Levofloxacin
  • Levonorgestrel
  • Lidoflazine
  • Linagliptin
  • Liraglutide
  • Lixisenatide
  • Lofexidine
  • Lopinavir
  • Lorcainide
  • Lumefantrine
  • Lutetium Lu 177 Dotatate
  • Macimorelin
  • Magaldrate
  • Magnesium Carbonate
  • Magnesium Hydroxide
  • Magnesium Oxide
  • Magnesium Peroxide
  • Magnesium Trisilicate
  • Mefloquine
  • Mestranol
  • Metformin
  • Methadone
  • Methotrimeprazine
  • Metronidazole
  • Mifepristone
  • Miglitol
  • Mirtazapine
  • Moxifloxacin
  • Nafarelin
  • Nateglinide
  • Nilotinib
  • Nizatidine
  • Nomegestrol
  • Norethindrone
  • Norfloxacin
  • Norgestimate
  • Norgestrel
  • Nortriptyline
  • Ofloxacin
  • Omeprazole
  • Ondansetron
  • Osilodrostat
  • Osimertinib
  • Oxaliplatin
  • Oxycodone
  • Ozanimod
  • Paliperidone
  • Panobinostat
  • Pantoprazole
  • Pasireotide
  • Pazopanib
  • Pentamidine
  • Perphenazine
  • Pimavanserin
  • Pioglitazone
  • Pipotiazine
  • Pirmenol
  • Pitolisant
  • Posaconazole
  • Prajmaline
  • Pramlintide
  • Probucol
  • Procainamide
  • Prochlorperazine
  • Promazine
  • Promethazine
  • Propafenone
  • Propiomazine
  • Protriptyline
  • Quetiapine
  • Quinidine
  • Quinine
  • Rabeprazole
  • Ranitidine
  • Ranitidine Bismuth Citrate
  • Ranolazine
  • Repaglinide
  • Ribociclib
  • Risperidone
  • Rosiglitazone
  • Roxatidine
  • Saxagliptin
  • Selpercatinib
  • Sematilide
  • Sertindole
  • Sertraline
  • Sevoflurane
  • Siponimod
  • Sirolimus
  • Sitagliptin
  • Sodium Bicarbonate
  • Sodium Phosphate
  • Sodium Phosphate, Dibasic
  • Sodium Phosphate, Monobasic
  • Solifenacin
  • Sorafenib
  • Sotalol
  • Spiramycin
  • Sulfamethoxazole
  • Sulpiride
  • Sultopride
  • Sunitinib
  • Tacrolimus
  • Tedisamil
  • Telavancin
  • Telithromycin
  • Temsirolimus
  • Tetrabenazine
  • Thiethylperazine
  • Tolazamide
  • Tolbutamide
  • Toremifene
  • Trazodone
  • Triclabendazole
  • Trifluoperazine
  • Triflupromazine
  • Trimeprazine
  • Trimethoprim
  • Trimipramine
  • Triptorelin
  • Vandetanib
  • Vardenafil
  • Vasopressin
  • Vemurafenib
  • Vildagliptin
  • Vinflunine
  • Voriconazole
  • Zolmitriptan
  • Zotepine
  • Zuclopenthixol

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Lisinopril
  • Pegvisomant
  • Telotristat Ethyl

Other Interactions

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Diabetes or
  • Gallbladder disease or
  • Heart rhythm problems or
  • Thyroid problems or
  • Vitamin B12 deficiency—Use with caution. May make these conditions worse.
  • End-stage kidney disease or
  • Liver disease (eg, cirrhosis, fatty liver disease)—Use with caution. The effects may be increased because of slower removal of the medicine from the body.

Proper Use

Take this medicine only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered.

Take this medicine with a glass of water on an empty stomach, at least 1 hour before or at least 2 hours after a meal.

Swallow the delayed-release capsule whole. Do not crush, break, or chew it.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For oral dosage form (delayed-release capsules):
    • For acromegaly:
      • Adults—At first, 20 milligrams (mg) 2 times a day. Your doctor may adjust your dose as needed and tolerated. However, the dose is usually not more than 80 mg per day.
      • Children—Use and dose must be determined by your doctor.

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Store in the refrigerator. Do not freeze.

You may keep the opened medicine at room temperature for up to 1 month. Throw away any unused medicine after 1 month.

Precautions

It is very important that your doctor check your progress at regular visits to make sure that this medicine is working properly. Blood and urine tests may be needed to check for unwanted effects.

This medicine may increase your risk of having gallstones (cholelithiasis), which may lead to swelling of the gallbladder (cholecystitis), bile ducts (cholangitis), or pancreas (pancreatitis). Check with your doctor right away if you have severe stomach pain with nausea and vomiting, indigestion, fever, chills, pains in the stomach or side, possibly radiating to the back, fast heartbeat, dark urine, bloating, or yellow eyes or skin.

This medicine may cause your blood sugar levels to rise or fall. It may cover up signs of hypoglycemia (low blood sugar), such as a change in your pulse rate. If you notice a change in the results of your blood sugar or urine sugar test, check with your doctor.

Octreotide may cause hypothyroidism (underactive thyroid gland). Check with your doctor right away if you have constipation, a depressed mood, dry skin and hair, cold skin, hair loss, hoarseness or husky voice, muscle cramps and stiffness, a slow heartbeat, weight gain, or unusual tiredness or weakness.

Contact your doctor right away if you have any changes to your heart rhythm. You might feel dizzy or faint, or you might have a fast, slow, pounding, or uneven heartbeat. Make sure your doctor knows if you had a heart rhythm problem, such as QT prolongation.

This medicine may cause a serious allergic reaction, called anaphylaxis, which can be life-threatening and requires immediate medical attention. Tell your doctor right away if you have a rash, itching, hoarseness, trouble breathing or swallowing, or any swelling of your hands, face, or mouth after using this medicine.

This medicine may improve fertility in some women, which could increase the risk for unplanned pregnancies. Talk to your doctor if you have any concerns.

Before you have any medical tests, tell the medical doctor in charge that you are using this medicine. The results of some tests may be affected by this medicine.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

  1. Bladder pain
  2. bloody or cloudy urine
  3. blurred vision
  4. chest tightness
  5. chills
  6. cough
  7. diarrhea
  8. difficult, burning, or painful urination
  9. dry mouth
  10. fever
  11. flushed, dry skin
  12. frequent urge to urinate
  13. fruit-like breath odor
  14. gaseous stomach pain
  15. general feeling of discomfort or illness
  16. headache
  17. increased hunger
  18. increased thirst
  19. increased urination
  20. joint pain
  21. loss of appetite
  22. lower back or side pain
  23. muscle aches or pains
  24. nausea
  25. pain or tenderness around the eyes and cheekbones
  26. recurrent fever
  27. shivering
  28. sore throat
  29. stomach pain or fullness
  30. stuffy or runny nose
  31. sweating
  32. swelling of the hands, ankles, feet, or lower legs
  33. trouble breathing
  34. trouble sleeping
  35. unexplained weight loss
  36. unusual tiredness or weakness
  37. vomiting
  38. yellow eyes or skin

Less common

  1. Anxiety
  2. body aches or pain
  3. burning feeling in the chest or stomach
  4. cold sweats
  5. confusion
  6. constipation
  7. cool, pale skin
  8. depressed mood
  9. dizziness
  10. dry skin and hair
  11. ear congestion
  12. fainting
  13. fast, slow, or irregular heartbeat
  14. hair loss
  15. hoarseness or husky voice
  16. indigestion
  17. loss of consciousness
  18. loss of voice
  19. muscle cramps or stiffness
  20. nervousness
  21. nightmares
  22. pounding in the ears
  23. seizures
  24. shakiness
  25. slurred speech
  26. sneezing
  27. stomach upset or tenderness
  28. weight gain

Incidence not known

  1. Black, tarry stools
  2. bleeding gums
  3. blindness
  4. bloating
  5. blood in vomit
  6. change in the frequency or amount of urine
  7. changes in vision
  8. chest pain or discomfort
  9. dark urine
  10. darkening of the skin
  11. deafness
  12. decreased vision
  13. dizziness, fainting, or lightheadedness when getting up suddenly from lying or sitting position
  14. double vision
  15. eye pain
  16. hives, skin rash
  17. itching, pain, redness, swelling, tenderness, or warmth of the skin
  18. light-colored stools
  19. loss of appetite
  20. migraine headache
  21. pain or discomfort in the arms, jaw, back, or neck
  22. pale skin
  23. paleness or cold feeling in the fingertips and toes
  24. pinpoint red spots on the skin
  25. problems with speech or speaking
  26. puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  27. severe cramping
  28. sores, ulcers, or white spots on the lips or in the mouth
  29. tearing
  30. tingling or pain in the fingers or toes when exposed to cold temperature
  31. unusual bleeding or bruising
  32. vomiting of blood or material that looks like coffee grounds
  33. weakness of the muscles in your face

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  1. Difficulty in moving
  2. joint swelling or redness
  3. lack or loss of strength
  4. passing gas
  5. pressure in the stomach
  6. swelling of the abdominal or stomach area

Less common

  1. Bleeding after defecation
  2. uncomfortable swelling around the anus

Incidence not known

  1. Decreased interest in sexual intercourse
  2. inability to have or keep an erection
  3. loss in sexual ability, desire, drive, or performance
  4. swelling of the breasts or breast soreness in both females and males
  5. unexpected or excess milk flow from breasts

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.