Proper Use

Drug information provided by: Merative, Micromedex®

Take this medicine exactly as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. To do so may increase the chance of side effects.

This medicine should come with a Medication Guide. Read and follow these instructions carefully. Ask your doctor if you have any questions.

Take this medicine on an empty stomach at least 1 hour before the first meal of the day or 2 hours after a meal.

Swallow the tablet whole. Do not crush, break, or chew it.

Stop taking other laxatives before starting treatment with naloxegol. Also, you should stop taking naloxegol if you have stopped taking narcotic pain medicines.

If you have trouble swallowing the tablet, you may crush and mix it with 120 milliliters (mL) (4 ounces) of water and drink it right away. Refill the glass with the same amount of water, stir, and drink it right away to make sure you get the full dose of this medicine.

If you have trouble swallowing the tablet, it may also be given through a nasogastric tube:

  • Draw up 30 mL (1 ounce) of water into a 60 mL syringe and flush it down the nasogastric tube.
  • Crush the tablet and mix it with 60 mL (2 ounces) of water.
  • Draw up the mixture using the 60 mL syringe and give it through the tube.
  • Add 60 mL of water to the mixture and use the same syringe to flush the tube for any remaining medicine to get the full dose of this medicine.

Do not eat grapefruit or drink grapefruit juice while you are using this medicine.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For oral dosage form (tablets):
    • For constipation caused by opioids:
      • Adults—25 milligrams (mg) once a day in the morning for at least 4 weeks (together with narcotic pain medicines). Your doctor may adjust your dose as needed.
      • Children—Use and dose must be determined by your doctor.

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Portions of this document last updated: Feb. 01, 2024

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