Description and Brand Names

Drug information provided by: IBM Micromedex

US Brand Name

  1. Provera

Canadian Brand Name

  1. Alti-Mpa

Descriptions


Medroxyprogesterone is used to treat amenorrhea (unusual stopping of menstrual periods) and abnormal uterine bleeding. It is also used to prevent endometrial hyperplasia (thickening of the lining of the uterus or womb) in women who are taking conjugated estrogens. This medicine is a progestin hormone.

This medicine is available only with your doctor's prescription.

This product is available in the following dosage forms:

  • Tablet

Before Using

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Use of medroxyprogesterone is not indicated in children. Safety and efficacy have not been established.

Geriatric

Although appropriate studies on the relationship of age to the effects of medroxyprogesterone have not been performed in the geriatric population, no geriatric-specific problems have been documented to date. However, elderly patients are more likely to have breast cancer, stroke, or dementia, which may require caution in patients receiving medroxyprogesterone.

Pregnancy

Information about this medroxyprogesterone-oral-route
Pregnancy Category Explanation
All Trimesters X Studies in animals or pregnant women have demonstrated positive evidence of fetal abnormalities. This drug should not be used in women who are or may become pregnant because the risk clearly outweighs any possible benefit.

Breastfeeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Drug Interactions

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

  • Tranexamic Acid

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Aprepitant
  • Carbamazepine
  • Dabrafenib
  • Darunavir
  • Fosaprepitant
  • Isotretinoin
  • Theophylline

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Amprenavir
  • Atazanavir
  • Bacampicillin
  • Betamethasone
  • Bexarotene
  • Colesevelam
  • Cyclosporine
  • Efavirenz
  • Fosamprenavir
  • Lamotrigine
  • Licorice
  • Mycophenolate Mofetil
  • Mycophenolic Acid
  • Nelfinavir
  • Prednisolone
  • Rifapentine
  • Ritonavir
  • Rufinamide
  • Selegiline
  • Telaprevir
  • Troleandomycin
  • Warfarin

Other Interactions

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following may cause an increased risk of certain side effects but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.

  • Caffeine

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Abnormal or unusual vaginal bleeding or
  • Blood clots (eg, deep vein thrombosis, pulmonary embolism), or history of or
  • Breast cancer, or history of or
  • Cancer (estrogen-dependent or progesterone-dependent), or history of or
  • Heart attack, history of or
  • Liver disease or
  • Stroke, history of—Should not be used in patients with these conditions.
  • Asthma or
  • Diabetes or
  • Endometriosis or
  • Epilepsy (seizures) or
  • Heart disease or
  • Hypercalcemia (high calcium in the blood) or
  • Hypercholesterolemia (high cholesterol in the blood) or
  • Hypertension (high blood pressure) or
  • Kidney disease or
  • Migraine headache or
  • Systemic lupus erythematosus (SLE) or
  • Thyroid problems—Use with caution. May make these conditions worse.

Proper Use

It is very important that you use this medicine only as directed by your doctor. Do not use more of it, do not use it more often, and do not use it for a longer time than your doctor ordered. To do so may cause unwanted side effects.

This medicine comes with a patient information leaflet. Read and follow the instructions in the leaflet carefully. Ask your doctor if you have any questions.

If you are taking this medicine together with an estrogen medicine, carefully follow the schedule your doctor gives you for both medicines.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For oral dosage form (tablets):
    • For prevention endometrial hyperplasia:
      • Adults—At first, 5 milligrams (mg) per day. Your doctor may adjust your dose as needed. However, dose is usually not more than 10 mg per day. It is usually taken everyday for 12 to 14 consecutive days per month.
      • Children—Use is not recommended.
    • For treatment of amenorrhea and abnormal uterine bleeding:
      • Adults—At first, 5 milligrams (mg) per day. Your doctor may adjust your dose as needed. However, dose is usually not more than 10 mg per day. It is usually taken everyday for 5 to 10 days.
      • Children—Use is not recommended.

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Precautions

It is very important that your doctor check your progress at regular visits to make sure this medicine is working properly and does not cause unwanted effects. Pelvic exam, breast exam, and mammogram (breast x-ray) may be needed to check for unwanted effects, unless your doctor tells you otherwise.

Using this medicine while you are pregnant can harm your unborn baby. Use an effective form of birth control to keep from getting pregnant. If you think you have become pregnant while using the medicine, tell your doctor right away.

Check with your doctor right away if you have pain in the chest, groin, or legs, especially the calves, difficulty with breathing, a sudden, severe headache, slurred speech, a sudden, unexplained shortness of breath, a sudden loss of coordination, or vision changes while using this medicine.

Using this medicine may increase your risk of heart attack, stroke, blood clots, dementia, breast cancer, or uterine cancer. Talk with your doctor about these risks.

Your risk of heart disease or stroke from this medicine is higher if you smoke. Your risk is also increased if you have diabetes or high cholesterol, or if you are overweight. Talk with your doctor about ways to stop smoking. Keep your diabetes under control. Ask your doctor about diet and exercise to control your weight and blood cholesterol level.

Check with your doctor right away if a severe headache or a sudden loss of vision or any change in vision occurs while you are using this medicine. Your doctor may want you to have your eyes checked by an ophthalmologist (eye doctor).

Pancreatitis may occur while you are using this medicine. Check with your doctor right away if you have sudden and severe stomach pain, chills, constipation, nausea, vomiting, fever, or lightheadedness.

Tell the medical doctor or dentist in charge that you are using this medicine before any kind of surgery (including dental surgery) or emergency treatment. Your doctor will decide whether you should continue using this medicine.

Before you have any medical tests, tell the medical doctor in charge that you are taking this medicine. The results of some tests may be affected by this medicine.

Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Incidence not known

  1. Abdominal or stomach pain
  2. absent, missed, or irregular menstrual periods
  3. anxiety
  4. blurred vision
  5. breast pain or tenderness
  6. changes in skin color
  7. chills
  8. clay-colored stools
  9. cough
  10. dark urine
  11. decrease in amount of urine
  12. diarrhea
  13. difficulty swallowing
  14. dizziness or lightheadedness
  15. eye pain
  16. fainting
  17. fast heartbeat
  18. fever
  19. headache
  20. hives or welts, itching, redness, swelling, or skin rash
  21. large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  22. loss of appetite
  23. menstrual changes
  24. nausea
  25. noisy, rattling breathing
  26. pain in the chest, groin, or legs, especially the calves
  27. pain, tenderness, or swelling of the foot or leg
  28. puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  29. severe, sudden headache
  30. shortness of breath
  31. slurred speech
  32. stopping of menstrual bleeding
  33. sudden loss of coordination
  34. sudden, severe weakness or numbness in the arm or leg
  35. sudden, unexplained shortness of breath
  36. swelling of the fingers, hands, feet, or lower legs
  37. troubled breathing at rest
  38. unexpected or excess milk flow from the breasts
  39. unpleasant breath odor
  40. unusual tiredness or weakness
  41. vaginal bleeding or spotting
  42. vision changes
  43. vomiting of blood
  44. weight gain
  45. yellow eyes or skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence not known

  1. Blemishes on the skin
  2. discouragement
  3. feeling sad or empty
  4. hair loss, thinning of hair
  5. increased hair growth, especially on the face
  6. irritability
  7. lack of appetite
  8. loss of interest or pleasure
  9. nervousness
  10. pimples
  11. sleepiness or unusual drowsiness
  12. tiredness
  13. trouble concentrating
  14. trouble sleeping
  15. weight changes

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.